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Functional studies of Wilms’ tumor gene 1 (WT1) in hematopoiesis and leukemia

Popular Abstract in Swedish Wilms tumör gen 1 (WT1) i normal blodbildning och vid akut leukemi Blodet innehåller en mängd olika celltyper som var och en har sin specifika funktion. De röda blodkropparna transporterar syre till kroppens alla vävnader, de vita blodkropparna skyddar mot olika typer av infektioner och blodplättarna är viktiga för blodkoagulering och sårläkning. Eftersom de mogna blodWilms’ tumor gene 1 (WT1) is a zinc-finger transcription factor that is involved in the development of urogenital organs and mesothelial tissues. It was initially identified as a tumor suppressor gene, based on the observation that somatic inactivation of the gene predispose for development of the pediatric kidney cancer Wilms’ tumor. A role for WT1 in hematopoiesis was suggested based on the fact

Bent Diamond Crystals and Multilayer Based Optics at the new 5-Station Protein Crystallography Beamline ‘Cassiopeia’ at MAX-lab

A new 5-station beamline for protein crystallography is being commissioned at the Swedish synchrotron light source MAX-II at Lund University. Of the 2K/gamma = 14 mrad horizontal wiggler fan, the central 2 mrad are used and split in three parts. The central 1 mrad will be used for a station optimized for MAD experiments and on each side of the central fan, from 0.5 mrad to 1 mrad, there are two fi

Generation of coherent short-wavelength radiation --- High-order harmonics and x-ray lasers

Popular Abstract in Swedish Den senaste utvecklingen av högintensitetslasrar har gjort det möjligt att studera nya fascinerande områden inom atomfysik. Två fenomen har studerats med Lunds Terawattlaser i intensitetsområdet 1013--1017 W/cm2: förstärkning av den spontana emissionen i plasmor från fasta strålmål och gasstrålmål, samt generering av övertonsstrålning av höga ordningar. Med hjälp av dThe recent availability of short-pulse, high-intensity, compact lasers has opened doors to new and fascinating areas in atomic physics. Using the Lund Terawatt Laser, the interaction of femtosecond, near-infrared and visible laser radiation with matter at intensities in the range 1013--1017 W/cm2 was studied. Out of many phenomena that occur in this intensity range, this thesis deals with two: th

Quantitative Genetics and Genome Structure in a Wild Population: the Use of a Great Reed Warbler Pedigree

Popular Abstract in Swedish Evolution är förändringen av en egenskap över flera generationer i en population. För att en sådan förändring ska kunna ske måste ärftlig variation finnas i populationen. Med detta menas att en gen som påverkar en egenskap, t.ex. en fågels vinglängd, måste finnas i olika former, så kallade alleler, som har olika effekt på egenskapen (t.ex. längre eller kortare vinge). MLong-term studies of birds play an important role in the understanding of quantitative traits in natural populations. The relative ease by which individual birds can be monitored and caught in the wild enable us collect detailed information from individuals throughout their life time, sometimes from several generations in a population. In this thesis I describe the utilization of a great reed warb

Hemicallotasis in Tibial Osteotomy using External Fixation. Patients, Pin Site Infection and Pin Site Care

Popular Abstract in Swedish Extern fixation är en metod för skelettfixation där perkutana pinnar och/eller vajrar fästes i skelettet och fixeras i en yttre metallram. Extern fixation används alltmer vid frakturläkning och förlängning/korrektion av deformiteter. En extern fixation ger stabilitet åt frakturer och osteotomier och möjlighet till gradvis förlängning/korrektion av deformiteter. BelastniExternal fixation has been more commonly used during the last decades for correction of bone and soft tissue deformities and in frcture healing. The most common complication of external fixation is pin site infection. Two hundred and nineteen younger and/or physically active patients (mean age 53 (18-75) years) suffering from knee osteoarthritis (OA) or knee deformities operated on by hemicallota

Till livs, till nytta

A broad survey of eating and food in 18th Century Sweden and in the taechings of Carl Linnaeus, who lectured and published extensively on these matters.

Claiming Knowledge: Strategies of Epistemology from Theosophy to the New Age

Popular Abstract in Swedish Avhandlingen analyserar sättet på vilket religiösa utsagor förändrats för att passa det moderna samhällets uppfattningar om naturvetenskap, om främmande folks religioner och om individens möjlighet att erhålla religiösa upplevelser. Som empiriskt material används en grupp historiskt och tematiskt besläktade rörelser, från det sena artonhundratalets teosofi fram till dagThe study addresses the question of how religious creativity in the West manages to adapt to the forces of modernity. The empirical data are drawn from a set of historically and thematically related movements, from late nineteenth century theosophy to the contemporary New Age.The dissertation is divided into three main sections. The first serves as a necessary background, presenting a number of th

Wrap-gated InAs nanowire field-effect transistor

Field-effect transistors (FETs) based on semiconductor nanowires (Bryllert et al., 2005) have the potential to improve certain aspects of existing planar FET technologies. The possibility to form wrap-gates gives an efficient gate coupling resulting in reduced drain-induced barrier lowering. Furthermore, lateral strain relaxation allows a new freedom in combining materials in heterostructures, whe

Industrial comparability of student artifacts in traceability recovery research - An exploratory survey

Abstract in UndeterminedAbout a hundred studies on traceability recovery have been published in software engineering fora. In roughly half of them, software artifacts developed by students have been used as input. To what extent student artifacts differ from industrial counterparts has not been fully explored in the literature. We conducted a survey among authors of studies on traceability recover

Degradation of wood polysaccharides by fungal glycoside hydrolases

The enzymatic degradation of wood polysaccharides such as cellulose and hemicellulose is an important process in nature. In addition, cellulases and hemicellulases can be used in industrial applications. Fuel ethanol can potentially be produced from wood by enzymatic hydrolysis of cellulose followed by yeast fermentation of the formed sugars. In this thesis, fungal glycoside hydrolases, cellulase

Total Cost Indicators - Operational Performance Indicators for managing environmental and economic efficiency

In this Licentiate Dissertation presents a new model for selecting environmental performance indicators in order to improve environmental management. The suggested Total Cost Indicators support a support a preventive approach to environmental management, where environmental issues are addressed before they arise - and before they become costs. The method of selecting indicators builds on earlier

Ruin probabilities and first passage times for self-similar processes.

This thesis investigates ruin probabilities and first passage times for self-similar processes. We propose self-similar processes as a risk model with claims appearing in good and bad periods. Then, in particular, we get the fractional Brownian motion with drift as a limit risk process. Some bounds and asymptotics for ruin probability on a finite interval for fractional Brownian motion are derive