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The Clinical Profile of Subjects Included in the Swedish National Register on Individuals with Severe Alpha 1-Antitrypsin deficiency.

The Swedish national register of severe alpha1-antitrypsin (AAT) deficiency was established in 1991. The main aims are to prospectively study the natural history of severe AAT deficiency, and to improve the knowledge of AAT deficiency. The inclusion criteria in the register are age ≥18 years, and the PiZ phenotype diagnosed by isoelectric focusing. The register is kept updated by means of repeated

Vitronectin in host pathogen interactions and antimicrobial therapeutic applications

Vitronectin (Vn) is a multifunctional glycoprotein profusely present in serum and bound to epithelial cell surfaces. It plays an important role in cell migration, tissue repair and regulation of membrane attack complex (MAC) formation. In the last decade the role of Vn has been extensively investigated in eukaryotic signalling and cell migration leading to the possibility of developing novel antic

Guiding Tourists through Haptic Interaction: Vibration Feedback in the Lund Time Machine

This paper describes the vibrationnal feedback that was chosen for the guiding interaction part of the Lund Time Machine application. This tourist guide provides information on points of interests along a trail, and guides the user along it. The interface uses audio and tactile modalities to be accessible in situations where the visual channel is not available. To navigate to the next goal, the us

Efficient Time Recursive Coherence Spectrum Estimation

The coherence spectrum is of notable interest as a bivariate spectral measure in a variety of application, and the topic has lately attracted notable interest with the recent formulation of several high-resolution data adaptive estimators. In this work, we present computationally efficient time recursive implementations of the recent iterative adaptive approach (IAA) estimator, examining both the

Impact of climate change on communities: revealing species' contribution.

Although climate is known to play an important role in structuring biological communities, high-resolution analyses of recent climatic impacts on multiple components of diversity are still sparse. Additionally, there is a lack of knowledge about which species drive community response to environmental change. We used a long-term breeding bird data set that encompasses a large latitudinal and altitu

SOFC Modeling Considering Electrochemical Reactions at the Active Three Phase Boundaries

Abstract in UndeterminedIt is expected that fuel cells will play a significant role in a future sustainable energy system, due to their high energy efficiency and the possibility to use renewable fuels. A fully coupled CFD model (COMSOL Multiphysics) is developed to describe an intermediate temperature SOFC single cell, including governing equations for heat, mass, momentum and charge transport as

A Bi-enzymatic Convergent Cascade for epsilon-Caprolactone Synthesis Employing 1,6-Hexanediol as a "Double-Smart Cosubstrate'

A bi-enzymatic cascade consisting of a Baeyer-Villiger monooxygenase and an alcohol dehydrogenase (ADH) was designed in a convergent fashion to utilise two molar equivalents of cyclohexanone (CHO) and one equivalent of 1,6-hexanediol as a 'double-smart cosubstrate' to produce epsilon-caprolactone (ECL) with water as sole by-product. The convergent enzymatic cascade reaction reported herein, is per

Microbial-mediated redistribution of ecosystem nitrogen cycling can delay progressive nitrogen limitation

Soil nitrogen (N) availability constrains future predictions of ecosystem primary productivity and carbon storage. The progressive N limitation (PNL) hypothesis predicts that forest net primary productivity (NPP) will decline with age, and that the response of NPP to elevated CO2 will attenuate through time due to negative feedbacks of NPP on the soil N cycle. A central assumption of the PNL hypot

Molecular imprinted polymer for solid-phase extraction of flavonol aglycones from Moringa oleifera extracts

Molecular imprinted polymer produced using quercetin as the imprinting compound was applied for the extraction of flavonol aglycones (quercetin and kaempferol) from Moringa oleifera methanolic extracts obtained using heated reflux extraction method. Identification and quantification of these flavonols in the Moringa extracts was achieved using high performance liquid chromatography with ultra viol

Coherent or inconsistent? Assessing energy security and climate policy interaction within the European Union

Energy security has become a key priority in the European Union’s (EU) policy. However, climate change mitigation commitments run in parallel. The purpose of this paper is to analyze the extent to which the EU’s climate change mitigation and energy security policies are coherent. The relationship is far from clear-cut, as both areas are complex and wide-ranging. We use a simple assessment framewor

Coupled biogeochemical cycles: eutrophication and hypoxia in temperate estuaries and coastal marine ecosystems

Nutrient fluxes to coastal areas have risen in recent decades, leading to widespread hypoxia and other ecological damage, particularly from nitrogen (N). Several factors make N more limiting in estuaries and coastal waters than in lakes: desorption (release) of phosphorus (P) bound to clay as salinity increases, lack of planktonic N fixation in most coastal ecosystems, and flux of relatively P-ric

Evaluation of clinical tools and their diagnostic use in distal symmetric polyneuropathy

Aims: To compare the diagnostic usefulness of tuning fork, monofilament, biothesiometer and skin biopsies in peripheral neuropathy in individuals with varying glucose metabolism. Methods: Normoglycaemic, impaired glucose tolerance (IGT) and type 2 diabetes (T2DM) individuals were recruited. Nerve conduction studies (NCS) and thermal threshold tests were performed. Vibrotactile sense was tested wit

Dual Application of Cryogel as Solid Support in Peptide Synthesis and Subsequent Protein-Capture

The use of a cryogel in a combined application as a solid support for automated synthesis of a peptide ligand followed by affinity chromatography of a target protein is evaluated. The advantage, of synthesizing the ligand directly on the cryogel, is the circumvention of the standard process of synthesizing a peptide on a solid support, followed by cleavage, purification, analysis, and finally immo

Neuropeptide Y is a minor autoantigen in newly diagnosed type 1 diabetes patients.

Autoantibodies (A) against Neuropeptide Y (NPY), was reported in 9% newly diagnosed type 1 diabetes (T1D) patients. A single nucleotide polymorphism (SNP) at rs16139 (T1128C) within the NPY-gene identified an amino acid substitution from leucine (L) to proline (P) (L7P) associated with both glucose tolerance and type 2 diabetes. We aimed to determine: (i) the influence of autoantibodies to leucine

Mixtures of Bose gases confined in concentrically coupled annular traps

A two-component Bose-Einstein condensate confined in an axially symmetric potential with two local minima, resembling two concentric annular traps, is investigated. The system shows a number of phase transitions that result from the competition between phase coexistence and radial-azimuthal phase separation. The ground-state phase diagram, as well as the rotational properties, including the (meta)

Spin-gap Isomer in 96Cd

Evidence has been obtained for the existence of the long predicted 16+ spin-gap isomer in 96Cd. The decay of the isomer was identified and studied following the use of an 850 MeV/u beam of 124Xe impinging on a Be target and the fragment recoil separator at the GSI Laboratory. Gamma decays from the fragments were detected using the RISING gamma ray array, in its stopped beam configuration, plus a s