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The syntheses of various amino- and hydroxy-substituted dehydrophenylalanine derivatives using the Heck-Jeffery protocol under non-solvent conditions in a ball mill are presented. The influences of electron-withdrawing groups and of the location of the heteroatom substituent relative to the halide are discussed. Suitably substituted ortho-amino dehydrophenylalanine derivatives undergo a cyclizatio

Popular Abstract in Swedish Begreppet systemförvaltning började användas i början på 1970-talet. Ämnet har betydelse ur flera perspektiv. Systemförvaltningskostnaderna är som regel betydligt större än systemutvecklingskostnaderna, vilket kan veri¬fieras med flera undersökningar gjorda i olika länder och under en tidsperiod omfattande ett par decennier. Det vetenskapliga intresset för systemförvaltThe term Software Maintenance was coined in the early 1970s. The subject has significance from several points of view. The costs associated with software maintenance are as a rule considerably higher than what the system cost to develop, which is borne out by many studies conducted in different countries over a period of twenty years. Scientific interest in software maintenance, on the other hand,

We report on the observation of excited states in the niobium isotope with masses 84, 85 and 86. These nuclei lie in the shape transition region known to occur in nuclei with 35 less-than-or-equal-to Z less-than-or-equal-to 40 and N = 45. Unambiguous identification was achieved by detecting gamma-rays in coincidence with mass-separated recoils produced in heavy-ion fusion reactions. Rotational ban

Objective: To conduct systematic long-term follow-up (LTFU) of patients in the Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis ( PRISMS) study to provide up to 8 years of safety, clinical and MRI outcomes on subcutaneous (SC) interferon (IFN) beta-1a in relapsing-remitting multiple sclerosis (RRMS). Methods: The original cohort of 560 patients was r

We have used transient photoinduced absorption on femtosecond to nanosecond time scales as well as delayed fluorescence up to microseconds to study the photogeneration and recombination of charges in thin films of the alternating polyfluorene copolymer poly[2,7-(9,9-dioctylfluorene)-alt-5,5-(4('),7(')-di-2-thienyl-2('),1(') ,3(')-benzothiadiazole)]. We interpret the results using a coupled rate eq

Abstract is not available

The purpose of this study was to observe how public health nurses perform blood pressure measurement. Structured observations were made of 21 randomly selected public health nurses while they performed three blood pressure measurements. The public health nurses used an overall correct method for blood pressure measurement. Five nurses out of 21 used the Tri-cuff but the soft cuff was most frequent

Contractile responses to phenylephrine and high-K+ were investigated in vitro in microvascular preparations from the rat medial plantar artery, a branch from the saphenous artery, obtained after short-term denervation in vivo. Two groups of animals were studied: (1) animals undergoing surgical resection of the saphenous nerve, and (2) animals undergoing surgical resection of both the sciatic and s

The isolated amyloid substance in hereditary cystatin C amyloid angiopathy (HCCAA) is mainly composed of a cystatin C variant devoid of the 10 amino terminal amino acid residues of extracellular cystatin C from healthy individuals. We have developed a procedure for protein sequencing directly from agarose gel electropherograms and used this in conjunction with isoelectric focusing to investigate t

Aims To describe guideline adherence and application of different stroke risk strati. cation schemes regarding antithrombotic therapy in real-life atrial. brillation (AF) patients and to assess which factors influence antithrombotic management decisions. Methods and results The Euro Heart Survey enrolled 5333 AF patients in 35 countries, in 2003 and 2004. Prescription of antithrombotic drugs, espe

Popular Abstract in Swedish I flexibla realtidssystem leder begränsningarna i processorkraft och minne till resurshanteringsproblem som måste hanteras väl för att både maximera systemets prestanda och undvika överlast. Problemet att tilldela processortid -- schemaläggning -- är väl undersökt och dynamisk schemaläggning är allmänt accepterad i industrin. För att göra säkra högnivåspråk, som Java, pIn a flexible real-time system, the constraints in available CPU time and memory lead to resource management problems, which must be handled carefully in order to maximize quality of service while avoiding overload. Managing CPU time -- scheduling -- is well studied and dynamic scheduling is widely accepted in the real-time industry. In order to make safe high-level languages, like Java, practical

To evaluate the accuracy of bone mineral composition determination by electron microprobe analysis (EDX) the measurements have been compared to instrumental neutron activation analysis (INAA) and chemical analysis (ICPES). Bone specimens from five femoral heads were used. The trabecular content of calcium (Ca) and phosphorus (P) was analyzed by the three different methods. The EDX method allows fo

This thesis is an empirical and theoretical exploration of the surprising finding that people often may fail to notice dramatic mismatches between what they want and what they get, a phenomenon my collaborators and I have named choice blindness. The thesis consists of four co-authored papers, dealing with different aspects of the phenomenon. Paper one presents an initial set of studies using a co

This thesis deals with the evaluation of measurements of water vapor transport and sorption in wood. It mainly concerns measurements of the weight response of a sample after a step change in relative humidity. The thesis consists of an introduction and eight papers. The eight papers have the following contents: 1. A description of the instrumentation and its performance characteristics. 2. Some f

During the last decades, cytogenetic biomarkers in peripheral lymphocytes have been used to assess exposure to carcinogenic or mutagenic agents in occupational settings. The first method in use assessed chromosomal aberrations (CA). It is generally accepted that chromosomal mutations are causal events in the development of neoplasia, and it has earlier been postulated, but not proven, that increas