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While the etiology of multiple myeloma (MM) is largely unknown, evidence for an inherited genetic susceptibility is provided by the two-fold increased risk of the disease seen in first-degree relatives of cases of MM. It is likely that part of this heritable risk is a consequence of the co-inheritance of low-risk genetic variants. The accumulated experience to date in identifying risk variants for
Historically, organizations developed their information systems in-house. Today, a large portion of information systems development is based on the acquisition of pre-made information systems, so-called commercially off-the-shelf (COTS) systems. This approach for developing information systems requires new skills and methods supporting the process of evaluating and selecting information systems. T
Over the last years an expanding family of small non-coding RNAs (sRNA) has been identified in eukaryotic genomes which behave as sequence-specific triggers for mRNA degradation, translation repression, heterochromatin formation and genome stability. To achieve their effectors functions, sRNAs associate with members of the Argonaute protein family. Argonaute proteins are segregated into three para
Kulturpristagare 1992 Kerstin Wallin journalist Erland Forsberg ikonmålare + Kulturpristagare 1993 Henrik Cervin domkyrkoorganist Gunnar Kampe kyrkoherde + Kulturpristagare 1994 Lars Hernqvist kyrkomusiker Jerker Leijon kyrkomusiker Ann-Marie Rydberg kyrkomusiker + Kulturpristagare 1995 Ingvar Rohr kyrkklocksexpert + Kulturpristagare 1996 Christina Löwestam bön- och sångdiktare Thomas Simson sport
Background: Airborne particles are associated with increased morbidity and mortality due to respiratory and cardiovascular diseases in polluted areas. There is a growing interest in nano-sized particles with diameter < 100 nm and their potential health effects. Heart rate variability (HRV) is a noninvasive method for cardiovascular risk prediction in high prevalent groups. Aim of study: The aim wa
Brottsoffer är ett ord med många konnotationer som har kritiserats för att antyda hjälplöshet och passivitet. Att kategoriseras som brottsoffer är inte alltid välkommet, men medför likväl fördelar, som till exempel möjligheten att driva en rättsprocess och tillgång till stöd och empati. I Sverige är Riksorganisationen Brottsofferjouren Sverige (BOJ) en viktig aktör när det gäller att ge brottsoffeCrime victim is a term with many connotations, which has been criticized for implying passivity and helplessness. To be categorized as a crime victim is not always welcomed. Still, being able to claim status as a victim is also connected to gains, in terms of both financial compensation and emotional support and compassion. In Sweden, Victim Support Sweden is an important actor in supplying help a
Recent experimental progress in coupling nanoscale conductors to superconducting microwave cavities has opened up for transport investigations of the deep quantum limit of light-matter interactions, with tunneling electrons strongly coupled to individual cavity photons. We have investigated theoretically the most basic cavity-conductor system with strong, single photon induced nonlocal transport e
Calmodulin (CaM) is the central mediator of intracellular Ca2+ signalling in cardiomyocytes, where it conveys the intricate Ca2+ transients to the proteins controlling cardiac contraction. We recently linked two separate mutations in CaM (N53I and N97S) to dominantly inherited catecholaminergic polymorphic ventricular tachycardia (CPVT), an arrhythmic disorder in which exercise or acute emotion ca
A Summary In a large cohort of elderly women followed for 10 years, we found that balance, gait speed, and self-reported history of fall independently predicted fracture. These clinical risk factors are easily evaluated and therefore advantageous in a clinical setting. They would improve fracture risk assessment and thereby also fracture prevention. Introduction The aim of this study was to identi
Objectives: To study: (I) work-loss seen as sick leave and disability pension before and after the start of first anti-TNF therapy in Swedish regional and national RA cohorts; (II) baseline predictors of a good future work prognosis at diagnosis and after anti-TNF start with a special focus on the impact of the disease activity level and the disease duration at treatment start. Methods: RA patien
The purpose of this study was to investigate women's wishes and need for knowledge concerning sexuality and relationships in connection with gynecological cancer. A total of 11 women were interviewed following the completion of their treatment for gynecological cancer. The data was analyzed using latent content analysis. Two main categories were identified: "The absence of knowledge about the body
Background: Persons with dementia receive health care and social services from a wide range of professional care providers during the disease trajectory, presenting risks of miscommunication, duplication and/or missed nursing interventions. Accordingly, the aim of this study was to investigate professional care providers' views on conditions for best practice in terms of collaboration and improvem
Modern industrial robots are traditionally programmed to follow desired trajectories, with the only feedback coming from the internal position/angle sensors in the joints. The robots are in general very accurate in tracking the desired motion, and they have become indispensable in many applications, such as spot welding and painting in the automotive industry. In more complex tasks, such as physic
Uncontrollable events such as adverse weather and volatile prices present considerable risks for arable farmers. Soil natural capital, which views the capacity of soil biodiversity to generate ecosystem services as a component of farm capital, could be important for the stability and resilience of arable production systems. We investigate therefore whether managing soil natural capital could be an
Popular Abstract in Swedish Hur lurar mördarbakterier våra celler? Neutrofiler och fagocytos räddar liv Utan vårt immunförsvar så skulle vi snabbt dö i infektioner från mikroorganismer. Det består ett komplicerat system av celler och molekyler som tillsammans kan klara av att stå emot attacker från bakterier, virus, svampar eller parasiter. Cellerna i immunförsvaret utgörs av vita blodkroppar ochNeutrophils are our most numerous and deadly white blood cells and without them we would succumb quickly to infections by pathogens. The main mechanism that the neutrophils employ for our protection is phagocytosis, where they eat and enclose their target inside a membrane-bound organelle, the phagosome. Neutrophil phagosomes are highly dynamic entities, and a large amount of antimicrobial substan
In order to achieve ultra-low emissions of both NOX and CO it is imperative to move the blow out limit towards leaner equivalence ratios and by supplying heat and reactive species to the flame zone the lean stability limit can be lowered. Heat and reactive species can be supplied to the flame zone by use of a pre-chamber combustor. In this study a central body burner, called the RPL (Rich-Pilot-Le
