Background: Soluble E-selectin (sE-selectin) is a marker of activation of vascular endothelium. Objective: To examine serum levels of sE-selectin in a cohort of 85 patients with early rheumatoid arthritis (RA) followed up for five years. Methods: sE-selectin levels were assessed annually using an enzyme linked immunosorbent assay (ELISA) and related to simultaneously obtained clinical and laborato

The use of monoclonal antibodies (MAbs) in cytotoxic conjugates (radionuclides, toxins, or drugs) for targeting tumor cells is restricted due to toxicity in vital organs. Through improved tumor targeting, it is possible to administer larger amounts of such labeled MAbs, thus improving the ability to eradicate tumor cells without increased normal organ toxicity. Extracorporeal affinity adsorption t

Human L68Q cystatin C is one of the known human amyloidogenic proteins. In its native state it is a monomer with alpha/beta structure. Experimental evidence suggests that L68Q variant associates into dimeric intermediates and that the dimers subsequently self-assemble to form amyloid deposits and insoluble fibrils. Details of the pathway of L68Q mutant amyloid formation are unclear; however, diffe

Popular Abstract in Swedish Solljusets effekter på abiotiska och bakteriella kolflöden i akvatiska system I denna avhandling behandlar jag solljusets effekter på organiskt material. Jag har analyserat hur solljus förändrar olika sorters löst organiskt kol och partikulärt organiskt kol. Vidare har jag utvärderat de indirekta effekterna som förändringar av löst organiskt kol har på bakterier. SlutlIn this Thesis, I studied some of the current aspects of organic matter photochemistry. I analyzed abiotic phototransformations of several types of dissolved (DOM) and particulate organic matter (POM). I also evaluated the effects of phototransformation of several types of DOM on bacteria. Finally, in a field experiment, I analyzed net effects of solar radiation on organic matter decomposition. DO

A new type of continuous, supermacroporous, monolithic, cryogel affinity adsorbent was developed, allowing specific fractionation and separation of human peripheral blood lymphocytes in a chromatographic format. The affinity adsorbent was used to design a novel cell separation strategy, which was based on the interaction of protein A from Staphylococcus aureus with cells bearing IgG antibodies on

The effects of small roundabouts on emissions and fuel consumption were evaluated using the “car-following” method in a before/after study. The results showed that at a roundabout replacing a signalised junction, CO emissions decreased by 29%, NOx emissions by 21%, and fuel consumption by 28%. At roundabouts, replacing yield regulated junctions, CO emissions increased on average by 4%, NOx emissio

Concentrations of plasma lipoproteins in 10 men who were habitual smokers were monitored for six weeks after they stopped smoking and related to changes in diet and body weight. The energy intake increased by 10% (p less than 0.05) owing to a higher consumption of carbohydrates and fat, and body weight increased by 2% (p less than 0.01). Plasma triglyceride, cholesterol, and low-density lipoprotei

We discuss algebraic properties of the Weyl product acting on modulation spaces. For a certain class of weight functions omega we prove that M-(omega)(p,q) is an algebra under the Weyl product if p epsilon [1, infinity] and 1

The Ax phenotype is an important subgroup of the ABO blood group system. Its inheritance does not always follow Mendelian rules and recent studies suggested that different alleles can result in this phenotype. This suggestion has been explored by cloning and sequencing exons 6 and 7 of the ABO gene and the intervening intron from members of six unrelated families expressing the Ax phenotype. Two f

Solid waste collection and hauling account for the greater part of the total cost in modern solid waste management systems. In a recent initiative, 3300 Swedish recycling containers have been fitted with level sensors and wireless communication equipment. thereby giving waste collection operators access to real-time information oil the status of each container. In this study. analytical modeling a

We describe the design of the secondary pion beam-line installed at the SIS 18Tm synchrotron at GSI, Darmstadt, and discuss the commissioning results. The experiments were performed with proton and C-12 primary beams at several energies using beryllium production targets. Pion yields in a momentum range between 0.4 and 2.8 GeV/c were identified, At the highest primary beam energies of 3.5 GeV for