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Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes
Multi-nucleotide variants (MNVs), defined as two or more nearby variants existing on the same haplotype in an individual, are a clinically and biologically important class of genetic variation. However, existing tools typically do not accurately classify MNVs, and understanding of their mutational origins remains limited. Here, we systematically survey MNVs in 125,748 whole exomes and 15,708 whole
An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment
How mixtures of immune cells associate with cancer cell phenotype and affect pathogenesis is still unclear. In 15 breast cancer gene expression datasets, we invariably identify three clusters of patients with gradual levels of immune infiltration. The intermediate immune infiltration cluster (Cluster B) is associated with a worse prognosis independently of known clinicopathological features. Furth
Effects of capturing a wide-orbit planet on planetary systems: system stability and habitable zone bombardment rates
Relentless and complex transits from a planetesimal debris disc
A pair of sub-Neptunes transiting the bright K-dwarf TOI-1064 characterized with CHEOPS
Hot Jupiters, cold kinematics : High phase space densities of host stars reflect an age bias
The entry geometry and velocity of planetary debris into the Roche sphere of a white dwarf
Actions speak louder than words : Attitudes, behaviour, and partisan identity in a polarised environmental domain
The relationship between environmental attitudes and behaviour is known to be weak, especially when these variables are measured as self-report items in surveys. In addition many environmental questions are highly polarised, making it even more problematic to use survey data to inform policy making. To better explore the attitude–behaviour gap in the context of environmental policies, along with i
Combination of searches for Higgs boson pairs in pp collisions at s=13TeV with the ATLAS detector
This letter presents a combination of searches for Higgs boson pair production using up to 36.1 fb−1 of proton–proton collision data at a centre-of-mass energy s=13 TeV recorded with the ATLAS detector at the LHC. The combination is performed using six analyses searching for Higgs boson pairs decaying into the bb¯bb¯, bb¯W+W−, bb¯τ+τ−, W+W−W+W−, bb¯γγ and W+W−γγ final states. Results are presented
Live bearing promotes the evolution of sociality in reptiles
Identifying factors responsible for the emergence and evolution of social complexity is an outstanding challenge in evolutionary biology. Here we report results from a phylogenetic comparative analysis of over 1000 species of squamate reptile, nearly 100 of which exhibit facultative forms of group living, including prolonged parent–offspring associations. We show that the evolution of social group
Observing charge separation in nanoantennas via ultrafast point-projection electron microscopy
Flyby encounters between two planetary systems II: exploring the interactions of diverse planetary system architectures
Linking the formation and fate of exo-Kuiper belts within Solar system analogues
Enhanced production of multi-strange hadrons in high-multiplicity proton-proton collisions
At sufficiently high temperature and energy density, nuclear matter undergoes a transition to a phase in which quarks and gluons are not confined: the quark-gluon plasma (QGP). Such an exotic state of strongly interacting quantum chromodynamics matter is produced in the laboratory in heavy nuclei high-energy collisions, where an enhanced production of strange hadrons is observed. Strangeness enhan
Regeneration of Assembled, Molecular-Motor-Based Bionanodevices
The guided gliding of cytoskeletal filaments, driven by biomolecular motors on nano/microstructured chips, enables novel applications in biosensing and biocomputation. However, expensive and time-consuming chip production hampers the developments. It is therefore important to establish protocols to regenerate the chips, preferably without the need to dismantle the assembled microfluidic devices wh
Anisotropic Pauli Spin-Blockade Effect and Spin-Orbit Interaction Field in an InAs Nanowire Double Quantum Dot
We report on experimental detection of the spin-orbit interaction field in an InAs nanowire double quantum dot device. In the spin blockade regime, leakage current through the double quantum dot is measured and is used to extract the effects of spin-orbit interaction and hyperfine interaction on spin state mixing. At finite magnetic fields, the leakage current arising from the hyperfine interactio
Legitimation and Delegitimation in Global Governance. Practices, Justifications, and Audiences
Fibril Charge Affects α-Synuclein Hydrogel Rheological Properties
In this paper, we have investigated the interactions between α-synuclein fibrils at different pH values and how this relates to hydrogel formation and gel properties. Using a combination of rheology, small-angle X-ray scattering, Raman spectroscopy, and cryo-transmission electron microscopy (cryo-TEM) experiments, we have been able to investigate the relationship between protein net charge, fibril
Multilamellar Vesicle Formation Probed by Rheo-NMR and Rheo-SALS under Large Amplitude Oscillatory Shear
The formation of multilamellar vesicles (MLVs) in the lyotropic lamellar phase of the system triethylene glycol mono n-decyl ether (C10E3)/water is investigated under large amplitude oscillatory shear (LAOS) using spatially resolved rheo-NMR spectroscopy and a combination of rheo-small angle light scattering (rheo-SALS) and conventional rheology. Recent advances in rheo-NMR hardware development fa