BackgroundImpulsive-compulsive disorders (ICDs) are commonly acknowledged as side effects of dopaminergic therapy in Parkinson’s disease (PD). While many large-scale studies have focused on prevalences and high-risk treatments, little is known about practical management of ICDs in clinical care and patients’ experiences.ObjectiveTo investigate how ICDs are recognized in clinical PD care, clinical

I exploit variation in the date of transition from analogue to digital television signal in the UK across more than 40,000 geographical units to investigate the causal impact of television on employment. Using an event study model, I find that the digital transition increases employment probabilities. The impact is driven by mothers, primarily through an increase in part-time employment. I also sh

I examine the causal effect of incentives to permanent employment on fertility by exploiting exogenous variation in subsidies given by the Spanish local authorities to employers converting temporary jobs into permanent ones. The amount of the subsidy varies across regions, in the age and gender of the employees whose contracts are converted, and within these three dimensions over time. Using admin

We examine the effect of screen-based activities on obesity and mental well-being for children, using a large survey dataset representative of the UK population and an event study model that exploits exogenous variation in the entry date of the digital television transition in the UK. The digital transition increased the number of available free television channels from 5 to 40, leading to a rise

This paper explores gender differences in the career paths of immigrant and native parents before and after childbirth using Spanish administrative data and an event study specification. I find an important gender pay gap emerging after childbirth for both immigrants and natives, and that the drivers of these gender pay gaps strongly differ between natives and immigrants: while children generate h

Precarious, flexibilised and informalised work has been a norm rather than the exception. Globally, formal employment, with a job contract, sick leave, vacation, rights to safe workspace, defined working hours, etc., has only been a reality for a minority. Much of the global workforce work outside formalised workspaces which include all types of economic activities deemed as ‘informal’, such as, s

This paper engages with limitations to social rights for different categories of migrants under EU law. By looking at how EU law construes accepted limitations to social rights and how the Court of Justice reviews such limitations, the paper suggests that there is room for different interpretation of limitations to social rights under secondary law in view of a more coherent understanding of their

BACKGROUND: Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by memory impairment and cognitive decline. Our previous research has demonstrated that pathological Tau and Amyloid-beta (Aβ) disrupt autophagy gene expression, independently. Other studies have shown that these pathological aggregates create a vicious cycle with oxidative stress.METHODS: In the current r

We explore the determinants of term premiums and evaluate the influence of the US market on term premiums in seven developed countries. Our analysis shows that poor economic conditions and high uncertainty lead to increased term premiums. Further, our results highlight the importance of US economic conditions and uncertainty factors as well as the supply of US government bonds as key drivers of in

Abstract Background Methods of assessment, treatment and referral rates of patients presenting with longstanding hip and groin pain (LHGP) are not well documented. The aim of this study was to investigate assessment and treatment of patients with LHGP among general practitioners (GPs) and physical therapists (PTs) in primary care. Methods An anonymous web-based survey was developed specifically fo

The Andes mountains extend north–south in a latitudinal gradient of 8500 km. Because of the great climatic variety and the peculiar north–south orographic distribution, lakes are highly diverse, including different lake origins and contrasting morphometries. We reviewed >700 ecological studies on Andean lakes to identify the main threats to these freshwater systems. The most important threats are

A diastereospecific synthesis of vicinally substituted 2-oxazolidinones from α,β-unsaturated lactams using m-chloroperoxybenzoic acid is reported. Several highly substituted 2-oxazolidinones were obtained in 19-46% yields in a one-pot reaction with complete control over the relative stereochemistry. The proposed reaction sequence consists of a Baeyer-Villiger oxidation, an epoxidation, and a conce

Recent research on normal human tissues identified omnipresent clones of cells, driven by somatic mutations known to be responsible for carcinogenesis (e.g., in TP53 or NOTCH1). These new insights are fundamentally changing current tumor evolution models, with broad oncological implications. Most studies are based on surgical remnant tissues, which are not available for many organs and rarely in a

Aberrant activation of anaplastic lymphoma kinase (ALK) drives neuroblastoma (NB). Previous work identified the RET receptor tyrosine kinase (RTK) as a downstream target of ALK activity in NB models. We show here that ALK activation in response to ALKAL2 ligand results in the rapid phosphorylation of RET in NB cells, providing additional insight into the contribution of RET to the ALK-driven gene

Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor which has been implicated in numerous solid and hematologic cancers. ALK mutations are reported in about 5-7% of neuroblastoma cases but the ALK-positive percentage increases significantly in the relapsed patient population. Crizotinib, the first clinically approved ALK inhibitor for the treatment of ALK-positive lung cancer has had le

Tumors with anaplastic lymphoma kinase (ALK) fusion rearrangements, including non-small-cell lung cancer and anaplastic large cell lymphoma, are highly sensitive to ALK tyrosine kinase inhibitors (TKIs), underscoring the notion that such cancers are addicted to ALK activity. Although mutations in ALK are heavily implicated in childhood neuroblastoma, response to the ALK TKI crizotinib has been dis

Activating mutations in full length anaplastic lymphoma kinase (ALK) have been reported in neuroblastoma and in anaplastic thyroid cancer. ALK-L1198F and ALKG1201E mutations were originally identified in anaplastic thyroid cancer (ATC) and characterized as constitutively activating mutations. In this study, we employed in vitro cell culture assays together with biochemical and in vivo Drosophila a