Medical decision-making is critical and the decisions are made under uncertain, complex, and dynamic conditions. In this regard, practitioners’ experiences and perceptions may provide a bottom-up knowledge of the issues, as well as a corresponding support system that assists them in learning to make decisions in critical situations. The current study aimed to examine these experiences in the Pakis

performance lecture and artistic research project in collaboration with Hypatia Vourloumis presented at "Spielart Festival", Munich, "What now" Festival, London and "performance Potentials" London

Demineralization assays, utilizing weak acids to isolate organics from biomineralized tissues, have recently been applied with increasing frequency to explore soft tissue preservation in fossils, revealing frequent retention of cells and other pliable microstructures in fossil bones. However, factors controlling long-term preservation of such labile structures remain mysterious. To address this, w

White adipose tissue (WAT) plays an important role in the integration of whole-body metabolism by storing fat and mobilizing triacylglycerol when needed. The released free fatty acids can then be oxidized by other tissues to provide ATP. AMP-activated protein kinase (AMPK) is a key regulator of metabolic pathways, and can be targeted by a new generation of direct, small-molecule activators. AMPK a

Inom beräkningskemi arbetar man mer med molekyler än atomer, studerar stökiometriska relationer, kinetik och geometri, interatomära eletronövergångar medan beräkningsfysik studerar mer atomer och dess kärnor, fasta tillståndet och intraatomära övergångar, oftast närmast mot atomens kärna. Interaktionerna sker på en storleksskala på nanometer eller mindre med energiövergångar som är diskontinuerligThis study presents an approach for partitioned fluid-structure interaction (FSI) applied to large structural deformations, where an incompressible turbulent solver is combined with a structural solver. The implementation is based upon two different open-source libraries by using MPI as a parallel communication protocol, the packages deal.II and OpenFOAM. FSI is achieved through a strongly-coupled

Tjänarinna är en kvinnlig tjänare som anses haft slavsstatus och fick arbeta 16 timmar om dagen för att kunna överleva. Deras löner var låga och deras arbetstimmar var höga. Detta är en beskrivning av ett förflutet yrke som inte har lämnats mycket utrymme i dagens skildringar av 1900-talets historiska händelser. Tjänarinna var ett yrke som utgjordes enbart av kvinnor och innebar ett heltidsarbete

Invasive alien species are frequently discussed in academic literature by practitioners, government agencies, and popular media, but what does it mean for a species to be alien and why it this seen as a bad thing? To answer these questions, I have analysed texts about invasive alien species in academic journals and in communication from government agencies. The almost totally unanimous answer to t

Hematopoietic stem cells (HSCs) are safeguarded from various threats such as stress, injury, or radiationwithin specialized microenvironments or niches within the bone marrow. In this thesis, we investigatedvarious facets of the bone marrow (BM) microenvironment and its critical role in hematopoiesis andrelated disorders.Initially, we elucidated the role of the Early Growth Response 1 (EGR1) gene

We all know that conflict creates displacement. Life becomes untenable in different ways, and people are forced to move; the majority ending up as internally displaced people within the nation-state, while others wind up in refugee camps in neighboring countries, and a very few seek asylum in faraway places. The recent war in Ukraine and the conflict in Syria since 2011 seemingly fit into this cla

Recent studies have revealed a close connection between cellular metabolism and the chronic inflammatory process of atherosclerosis. While the link between systemic metabolism and atherosclerosis is well established, the implications of altered metabolism in the artery wall are less understood. Pyruvate dehydrogenase kinase (PDK)-dependent inhibition of pyruvate dehydrogenase (PDH) has been identi

Bakgrund: Brist på slutenvårdsplatser och den åldrande befolkningen har lett till att allt fler svårt multisjuka äldre vuxna vårdas i hemmet. Ansvarsområdena i hemsjukvården är komplexa och mycket ligger på distriktssköterskans förmåga att i en komplicerad miljö kunna fatta avancerade beslut och göra bedömningar av patienters behov och hälsotillstånd. Syfte: Syftet var att beskriva hur distriktskö

Myocardial infarction (MI) leads to irreversible ischemic damage of the heart muscle and is the leading cause of heart failure. The ischemic cardiac injury triggers a potent local and systemic immune response. In the acute phase post-MI, neutrophils infiltrate the myocardium in large numbers and induce further cardiomyocyte death, expanding the infarcted area. The alarmin S100A8/A9 is a proinflamm

Background Few studies have evaluated the role of artificial intelligence (AI) in prior screening mammography. Purpose To examine AI risk scores assigned to screening mammography in women who were later diagnosed with breast cancer. Materials and Methods Image data and screening information of examinations performed from January 2004 to December 2019 as part of BreastScreen Norway were used in thi

Background: Gallbladder cancer (GBC) is rare but aggressive. The extent of surgical intervention for different GBC stages is non-uniform, ranging from cholecystectomy alone to extended resections including major hepatectomy, resection of adjacent organs and routine extrahepatic bile duct resection (EBDR). Robust evidence here is lacking, however, and survival benefit poorly defined. This study ass

Motivation: AliGater is an open-source framework to accelerate the development of bioinformatic pipelines for the analysis of large-scale, high-dimensional flow cytometry data. AliGater provides a Python package for automatic feature extraction workflows, as well as building blocks to construct analysis pipelines. Results: We illustrate the use of AliGater in a high-resolution flow cytometry-based