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The antimicrobial peptide LL-37 is anti-inflammatory and proapoptotic in human periodontal ligament cells.

The antimicrobial peptide LL-37 is anti-inflammatory and proapoptotic in human periodontal ligament cells. J Periodont Res 2011; doi: 10.1111/j.1600-0765.2011.01436.x. © 2011 John Wiley & Sons A/S Background and Objective: The antimicrobial peptide LL-37 is expressed in periodontal tissue, and variations in LL-37 levels have been associated with periodontal disease. The effects of LL-37 on per

Practical Design and Performance Based Regulations

The paper presents a sample design of a multi-storey building with respect to the fire safety. Three design strategies are examined, a standard solution according to the requirements, a fire safety engineering design without a sprinkler system and finally a fire safety engineering design with a sprinkler system. The objective was to demonstrate different design strategies and still comply with the

Trend analysis of Icelandic discharge, precipitation and temperature series.

This study is a part of a Nordic co-operative research project, Climate and Energy, funded by Nordic Energy Research and the Nordic energy sector. The project has the objective of a comprehensive assessment of the impact of climate change on Nordic renewable energy resources including hydropower, wind power, biofuels and solar energy. In this paper, the long term variability of precipitation, temp

Economic Policies for Healthier Food Intake: The Impact on Different Household Categories

This paper simulates the impact across household types of fully funded tax reforms designed to increase consumers’ fiber intake from grain consumption. Our results suggest that household types with the highest initial consumption share of fiber-rich products—i.e., households without children (seniors, couples without children, and single women without children)—experience the highest increase in f

MicroRNAs in the failing heart - Novel therapeutic targets?

Abstract Heart failure is a common and disabling disease with high mortality that carries substantial societal costs. Current therapeutic strategies are aimed at relieving symptoms, avoiding hospitalization, and prolonging life, but disease progression is ultimately inevitable. MicroRNAs (miRNAs) are short, non-coding RNA molecules with pervasive roles in eukaryotic biology, annealing to complimen

WNT5A-mediated β-catenin-independent signalling is a novel regulator of cancer cell metabolism.

WNT5A has been identified as an important ligand in the malignant progression of a number of tumours. Although WNT5A signalling is often altered in cancer, the ligand's role as either a tumour suppressor or oncogene varies between tumour types and is a contemporary issue for investigators of β-catenin-independent WNT signalling in oncology. Here, we report that one of the initial effects of active

Simulation and parametric study of a film-coated controlled-release pharmaceutical.

Pharmaceutical formulations can be designed as Multiple Unit Systems, such as Roxiam CR, studied in this work. The dose is administrated as a capsule, which contains about 100 individual pellets, which in turn contain the active drug remoxipride. Experimental data for a large number of single pellets can be obtained by studying the release using microtitre plates. This makes it possible to study t

Physical Activity and Concordance between Objective and Perceived Walkability.

PURPOSE:: To investigate concordance between objective and perceived neighborhood walkability, their associations with self-reported walking and objective physical activity, and sociodemographic characteristics of individuals in neighborhoods with objectively assessed high walkability who misperceive it as low. METHODS:: In 1,925 individuals aged 20-66 years, recruited from administrative areas in

Corporate Supply Chain Responsibility: Drivers and Barriers for Sustainable Food Retailing

The paper aims to provide a systematic overview of the drivers and barriers for food retailers to implement corporate supply chain responsibility. The research is based on a literature analysis and semi-structured interviews with food retailers, with primary focus on Swedish conventional supermarket chains. The paper contributes to the existing body of research by providing the food retailers’ own

Global maritime security studies: The rise of a geopolitical area of policy and research

Global maritime security has been a subject of analysis and debate in the West since the onset of the European expansion. This article distinguishes four main periods with regard to the doctrines and practices of global maritime security since c. 1450, during which the role of the state in relation to private actors has shifted. As a concept of global policy making, however, maritime security only

(Dis)Abled bodies, gender, and citizenship in the Swedish sports movement

The aim of this article is to examine how the Swedish Sports Organization for the Disabled (SHIF) portrays disabled people. A text analysis of two policy documents, 'Disability Sports Policy Programme' and 'Sports Objectives - A Summary of Aims and Guidelines for the Sports Movement', examines ways in which sports are supposed to affect people's bodies and contribute to society. Counter to its own

Molecularly Imprinted Polymer Beads Prepared by Pickering Emulsion Polymerization for Steroid Recognition

Pickering emulsion polymerization was used to synthesize molecularly imprinted polymer beads for the selective recognition of 17-beta-estradiol under aqueous conditions. Scanning electron microscopy analysis indicated that the imprinted polymer beads had a small diameter with a narrow size distribution (18.9 +/- 2.3 mu m). The reduction in particle size achieved in this study was attributed to the

Cardiac metabolism measured noninvasively by hyperpolarized (13)C MRI.

Pyruvate is included in the energy production of the heart muscle and is metabolized into lactate, alanine, and CO(2) in equilibrium with HCO(3) (-). The aim of this study was to evaluate the feasibility of using (13)C hyperpolarization enhanced MRI to monitor pyruvate metabolism in the heart during an ischemic episode. The left circumflex artery of pigs (4 months, male, 29-34 kg) was occluded for