Sökresultat

Filtyp

Din sökning på "*" gav 530126 sökträffar

miR-18b overexpression identifies mantle cell lymphoma patients with poor outcome and improves the MIPI-B prognosticator.

Recent studies show that mantle cell lymphoma (MCL) express aberrant miRNA profiles, however, the clinical effect of miRNA expression has not previously been examined and validated in prospective, large, homogenously treated cohorts. We analyzed diagnostic MCL samples from the Nordic MCL2 and MCL3 clinical trials, in which all patients had received Rituximab-high-dose cytarabin alternating with Ri

Finite gap Jacobi matrices, III. Beyond the Szegő class

Let e⊂R be a finite union of ℓ+1 disjoint closed intervals, and denote by ω j the harmonic measure of the j left-most bands. The frequency module for e is the set of all integral combinations of ω 1,…,ω ℓ . Let {a˜n,b˜n}∞n=−∞ be a point in the isospectral torus for e and p˜n its orthogonal polynomials. Let {an,bn}∞n=1 be a half-line Jacobi matrix with an=a˜n+δan , bn=b˜n+δbn . Suppose ∑n=1∞∣δan∣2+

The ribosome story: An overview of structural studies of protein synthesis on the ribosome

Protein synthesis has been studied for more than half a century, but the atomic details of this complex system, the ribosome, began to be revealed in 1999 and 2000 through crystallographic structure determinations. As with all biomolecular systems, the advent of atomic structures are milestones in the process of relating function to structure. During these 10 years there has been an avalanche in b

Regulation of human papillomavirus gene expression by splicing and polyadenylation.

Human papillomaviruses (HPVs) are small DNA tumour viruses that are present in more than 99% of all cervical cancers. The ability of these viruses to cause disease is partly attributed to the strict coordination of viral gene expression with the differentiation stage of the infected cell. HPV gene expression is regulated temporally at the level of RNA splicing and polyadenylation, and a dysregulat

Increased Risk of Arthropathies and Joint Replacement Surgery in Patients With Genetic Hemochromatosis: A Study of 3,531 Patients and Their 11,794 First-Degree Relatives

Objective Genetic hemochromatosis (GH) is an autosomal recessive disease in individuals of Northern and Western European descent. Heterozygosity for the C282Y mutation is common (620%). Arthropathy is one of the few complications of GH suggested not to be associated with iron body stores; synovial iron deposition remains in iron-depleted patients. Previous studies suggest an elevated prevalence of

Search for Quantum Black Hole Production in High-Invariant-Mass Lepton plus Jet Final States Using pp Collisions at root s=8 TeV and the ATLAS Detector

This Letter presents a search for quantum black-hole production using 20.3 fb(-1) of data collected with the ATLAS detector in pp collisions at the LHC at root s = 8 TeV. The quantum black holes are assumed to decay into a final state characterized by a lepton (electron or muon) and a jet. In either channel, no event with a lepton-jet invariant mass of 3.5 TeV or more is observed, consistent with

Cosmopolitan practices in social contexts: Swedish skilled migrants in the Netherlands

Empirical work on cosmopolitanism has, to a large extent, focused on the precon- ditions for and character of cosmopolitan practices. Drawing on interviews with Swedish skilled migrants in the Netherlands, this article contributes to the cosmo- politan research by focusing on the socially structured variety of cosmopolitan practices. Based on an understanding of cosmopolitanism as an active and re

Social influence interpretation of interpersonal processes and team performance over time using Bayesian model selection

The team behavior literature is ambiguous about the relations between members’ interpersonal processes—task debate and task conflict—and team performance. From a social influence perspective, we show why members’ interpersonal processes determine team performance over time in small groups. Together, over time, dissenting in-group minorities who share information (via debate) with majorities, who s

Search for contact interactions in dimuon events from pp collisions at root s=7 TeV with the ATLAS detector

A search for contact interactions has been performed using dimuon events recorded with the ATLAS detector in proton-proton collisions at root s = 7 TeV. The data sample corresponds to an integrated luminosity of 42 pb(-1). No significant deviation from the standard model is observed in the dimuon mass spectrum, allowing the following 95% C. L. limits to be set on the energy scale of contact intera

Urban Peacebuilding in ethno-nationally divided and contested cities: the case of Mostar

This article seeks to outline a conceptual landscape that can assist us to better grasp how urban communities torn and traumatised by violent conflicts remain divided in peace and resistant to liberal peacebuilding efforts. It suggests that peacebuilding needs to be urbanised to better address and mitigate tensions and ethnocratic spatial practices in divided cities. The urban is suggested as a pr

Risk factors, outcome and impact of empirical antimicrobial treatment in extended-spectrum β-lactamase-producing Escherichia coli bacteraemia.

Background: To investigate patient characteristics and empirical antimicrobial treatment of extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) bacteraemia, to determine risk factors, outcome and impact of empirical antimicrobial treatment. Methods: We performed a retrospective case-control study of all patients diagnosed with ESBL-EC from January 2011 to September 2012. The control

Fetal and neonatal alloimmune thrombocytopenia.

Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is an alloimmune disorder resulting from platelet opsonization by maternal antibodies that destroy fetal platelets. The major risk of FNAIT is severe bleeding, particularly intracranial hemorrhage. Miscarriage has also been reported but the incidence requires further study. Analogous to adult autoimmune thrombocytopenia (ITP), the major target

SPARC: A Potential Prognostic and Therapeutic Target in Pancreatic Cancer.

Pancreatic cancer is a complex and heterogeneous disease that often lacks disease-specific symptoms in early stages. The malignancy is currently the fourth leading cause of cancer-related death in Western countries. In advanced stages, the overall 5-year survival is less than 1% to 2%. Most available treatments lack convincing cost-efficiency determinations and are generally not associated with re

Influence of interface roughness in quantum cascade lasers

We use a numerical model based on non-equilibrium Green's functions to investigate the influence of interface roughness (IFR) scattering in terahertz quantum cascade lasers. We confirm that IFR is an important phenomenon that affects both current and gain. The simulations indicate that IFR causes a leakage current that transfers electrons from the upper to the lower laser state. In certain cases,

Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid Stenting Study): an interim analysis of a randomised controlled trial

Background Stents are an alternative treatment to carotid endarterectomy for symptomatic carotid stenosis, but previous trials have not established equivalent safety and efficacy. We compared the safety of carotid artery stenting with that of carotid endarterectomy. Methods The International Carotid Stenting Study (ICSS) is a multicentre, international, randomised controlled trial with blinded adj