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Longitudinal three-dimensional visualisation of autoimmune diabetes by functional optical coherence imaging.
It is generally accepted that structural and functional quantitative imaging of individual islets would be beneficial to elucidate the pathogenesis of type 1 diabetes. We here introduce functional optical coherence imaging (FOCI) for fast, label-free monitoring of beta cell destruction and associated alterations of islet vascularisation.
Irreversible pan-ERBB inhibitor canertinib elicits anti-leukaemic effects and induces the regression of FLT3-ITD transformed cells in mice.
Recent findings have indicated that tyrosine kinase inhibitors (TKIs) targeting the ERBB receptor family display anti-leukaemic effects, despite the lack of receptor expression on human leukaemic cells. The occurrence of activating mutations in the gene encoding FMS-like tyrosine kinase 3 (FLT3) in patients with acute myeloid leukaemia (AML) has rendered inhibition of this receptor a promising the
Impact of hospital volume on local recurrence and distant metastasis in bladder cancer patients treated with radical cystectomy in Sweden
Objective. This study evaluated the impact of hospital volume on local recurrence and distant metastasis in a population-based series of radical cystectomy patients in Sweden. Material and methods. All patients who underwent cystectomy for bladder cancer in 1997-2002 in Sweden and were reported to the National Bladder Cancer Registry were included. A high-volume hospital (HVH) was defined as one w
Imaging techniques in the management of abnormal vaginal bleeding in non-pregnant women before and after menopause.
Transvaginal ultrasound plays a pivotal role in the management of non-pregnant women with abnormal vaginal bleeding. No other imaging technique has a role in the triage of these women. In women with postmenopausal bleeding, ultrasound is used to categorise women as at low or high risk of endometrial cancer, and the result of the ultrasound examination is the basis for further management. In women
Evapotranspiration and water balance of high-elevation grassland on the Tibetan Plateau
High-elevation grasslands of the Cyperaceae Kobresia pygmaea cover nearly half a million km2 on the Tibetan Plateau. As a consequence of climate change, precipitation patterns in this monsooninfluenced region may change with possible consequences for grassland productivity. Yet, not much is known about the water cycle in this second largest alpine ecosystem of the world. We measured the evapotrans
Optics of cone photoreceptors in the chicken (Gallus gallus domesticus).
Vision is the primary sensory modality of birds, and its importance is evident in the sophistication of their visual systems. Coloured oil droplets in the cone photoreceptors represent an adaptation in the avian retina, acting as long-pass colour filters. However, we currently lack understanding of how the optical properties and morphology of component structures (e.g. oil droplet, mitochondrial e
Spatial evolutionary and ecological vicariance analysis (SEEVA), a novel approach to biogeography and speciation research, with an example from Brazilian Gentianaceae
Aim Spatial evolutionary and ecological vicariance analysis (SEEVA) is a simple analytical method that evaluates environmental or ecological divergence associated with evolutionary splits. It integrates evolutionary hypotheses, phylogenetic data, and spatial, temporal, environmental and geographical information to elucidate patterns. Using a phylogeny of Prepusa Mart. and Senaea Taub. (Angiosperma
The necessity of a test reading after 1 week to detect late positive patch test reactions in patients with oral lichen lesions.
Establishing the clinical relevance of contact allergy to dental materials in patients with oral lichen lesions (OLL) may be difficult, and tests are often read only on day 3 or day 4; also, concentration of the tested allergens may vary. Several studies on dermatitis patients have shown that additional positive patch test reactions can be found after day 4. Therefore, the aim of the present study
A positive turning point in life--how persons with late effects of polio experience the influence of an interdisciplinary rehabilitation programme.
OBJECTIVE: To describe and enhance our understanding of how persons with late effects of polio experience the influence of an interdisciplinary rehabilitation programme. PARTICIPANTS: Twelve persons with clinically verified late effects of polio who had participated in an individualized, goal-oriented, comprehensive interdisciplinary rehabilitation programme. METHODS: Qualitative research intervie
Attained education and self-assessed health later in life when diagnosed with diabetes in childhood: a population-based study.
Wennick A, Hallström I, Lindgren B, Bolin K. Attained education and self-assessed health later in life when diagnosed with diabetes in childhood: a population-based study. Background: Previous studies have reported conflicting findings on academic achievement in children with type 1 diabetes, and generally lower self-assessed health status among respondents with diabetes. Objective: Thus, in this
General control-theoretical framework for online resource allocation in computing systems
System-theoretical methods are already used for the control of computing systems, but much more can be done exploiting said methods for their design. This requires to express in control-theoretical terms desires and specifications that originate in the computer science do- main, which may not be immediate. It also requires to accept that part of the addressed system be modified, which may pose som
Being in a Bubble: the experience of loneliness among frail older people.
The aim of this study was to explore the experience of loneliness among frail older people living at home.
Current approaches to measuring human islet-antigen specific T cell function in type 1 diabetes.
Type 1 diabetes (T1D) is an autoimmune disease caused by the T cell-mediated destruction of the pancreatic insulin-producing beta cells. Currently there are no widely accepted and standardized assays available to analyse the function of autoreactive T cells involved in T1D. The development of such an assay would greatly aid efforts to understand the pathogenesis of T1D and is also urgently require
Patients experiences of information and support during the first six months after heart or lung transplantation.
BACKGROUND: Heart or lung recipients are taught about a new lifestyle, risk factors, medication, food restrictions and exercise so they can take an active role and responsibility for disease management after transplantation. However, little is known about patients' experiences of information and support in these situations. OBJECTIVE: The aim of the study was to illuminate how patients, six months
GLI1-dependent transcriptional repression of CYLD in basal cell carcinoma
CYLD is a deubiquitination enzyme that regulates different cellular processes, such as cell proliferation and cell survival. Mutation and loss of heterozygosity of the CYLD gene causes development of cylindromatosis, a benign tumour originating from the skin. Our study shows that CYLD expression is dramatically downregulated in basal cell carcinoma (BCC), the most common cancer in humans. Reduced
Afrikansk skönlitteratur på svensk bokmarknad 1961-1981 : Bo Cavefors Bokförlag och Afrika berättar
This article examines the selection, marketing and reception of African fiction on the Swedish book market of the 1960s and 70s, through the series Afrika berättar, launched by Bo Cavefors Publishing, Ltd. Bo Cavefors was a Swedish publisher of writers such as Wole Soyinka, Ngũgĩ wa Thiong’o and José Luandino Vieira. The article discusses the way in which these literary works were received taking
Herbivory makes major contributions to ecosystem carbon and nutrient cycling in tropical forests
The functional role of herbivores in tropical rainforests remains poorly understood. We quantified the magnitude of, and underlying controls on, carbon, nitrogen and phosphorus cycled by invertebrate herbivory along a 2800m elevational gradient in the tropical Andes spanning 12 degrees C mean annual temperature. We find, firstly, that leaf area loss is greater at warmer sites with lower foliar pho
Variation in the mechanical properties of flight feathers of the blackcap Sylvia atricapilla in relation to migration
Migration causes temporal and energetic constraints during plumage development, which can compromise feather structure and function. In turn, given the importance of a good quality of flight feathers in migratory movements, selection may have favoured the synthesis of feathers with better mechanical properties than expected from a feather production constrained by migration necessities. However, n
Lower-Middle Ordovician delta C-13 chemostratigraphy of western Baltica (Jamtland, Sweden)
The province of Jamtland, central Sweden, records a well-preserved but very thin suite of the Lower-Middle Ordovician cool-water carbonates. In this study we present the first carbon isotope profile for these strata on the basis of whole-rock samples from the Brunflo 2 core. The studied succession is 41.55 m thick and includes, in ascending order, the Bjorkasholmen Formation, Latorp Limestone, Toy