BACKGROUND: Cerebral endothelial dysfunction occurs in a spectrum of neurodegenerative diseases. Whether biomarkers of microvascular endothelial dysfunction can predict dementia is largely unknown. We explored the longitudinal association of midregional pro-atrial natriuretic peptide (MR-proANP), C-terminal endothelin-1 (CT-proET-1) and midregional proadrenomedullin (MR-proADM) with dementia and s

We consider the Dirichlet-Neumann iteration for partitioned simulation of thermal fluid-structure interaction, also called conjugate heat transfer. We analyze its convergence rate for two coupled fully discretized 1D linear heat equations with jumps in the material coefficients across these. These are discretized using implicit Euler in time, a finite element method on one domain, a finite volume

Magnetic resonance imaging enables detailed in vivo study of complex flow through 3D, time-resolved phase contrast imaging (4D flow). 4D flow may reveal previously unknown aspects of the physiology of intracardiac blood flow, and possibly elucidate pathophysiological processes that have yet to manifest themselves outside the heart.The purpose of this thesis is to examine the physiological role of

I denna publikation presenteras en idégenerator som är avsedd att användas när man letar efter nya alternativ för att hantera företagets avbrottsrisker. Det inledande skedet av sökandet brukar karaktäriseras som ”brainstorming” dvs. det gäller att hitta så många nya riskhanteringsalternativ som möjligt, gärna otraditionella sådana. Här kan idégeneratorn varit till stor hjälp. Den består av 22 olik

Defensive coping (DefS), oxidative stress, inflammation, and related amino acids (phenylalanine [Phe] and tyrosine [Tyr]) have been implicated in cardiovascular disease. This study assessed whether inflammation, oxidative stress, changes in essential amino acids, and altered coping strategies are correlated with subclinical vascular changes in African (n = 82) and Caucasian (n = 100) men from the

Objective: To investigate whether the Multi-Biomarker Disease Activity (MBDA) score predicts optimal add-on treatment in patients with early rheumatoid arthritis (RA) who were inadequate responders to MTX (MTX-IRs). Methods: We analyzed data from 157 MTX-IRs (with a Disease Activity Score using the erythrocyte sedimentation rate [DAS28-ESR] >3.2) from the Swedish Pharmacotherapy (SWEFOT) trial who

The heterodimer HIF-1α (hypoxia inducible factor)/HIF-β (also known as ARNT-aryl hydrocarbon nuclear translocator) is a key mediator of cellular response to hypoxia. The interaction between these monomer units can be modified by the action of small molecules in the binding interface between their C-terminal heterodimerization (PasB) domains. Taking advantage of the presence of several cysteine res

Background: Electrodermal reactivity has been successfully used as indicator of interest, curiosity as well as depressive states. The measured reactivity depends on the quantity of sweat secreted by those eccrine sweat glands that are located in the hypodermis of palmar and plantar regions. Electrodermal hyporeactive individuals are those who show an unusual rapid habituation to identical non-sign

Objectives: We wanted to investigate the effects of postoperative pulmonary hypertension (PHpostop: mean pulmonary artery pressure [MPAP] ≥ 25 mmHg), diastolic pressure gradient (DPG), pulmonary vascular resistance (PVR), and repeated hemodynamic measurements on long-term survival after heart transplantation (HT). Design: Eighty-nine patients who underwent HT at Skåne University Hospital in Lund i

Robust and efficient target-tracking algorithms embedded on moving platforms, are a requirement for many computer vision and robotic applications. However, deployment of a real-time system is challenging, even with the computational power of modern hardware. As inspiration, we look to biological lightweight solutions-lightweight and low-powered flying insects. For example, dragonflies pursue prey

A new perspective on the modelling of settling behaviour in water resource recovery facilities is introduced. The ultimate goal is to describe in a unified way the processes taking place both in primary settling tanks (PSTs) and secondary settling tanks (SSTs) for a more detailed operation and control. First, experimental evidence is provided, pointing out distributed particle properties (such as

Practitioners may face difficulties in the interpretation of fire codes since they often present so called "magic numbers", i.e. numbers available in the codes which are listed for providing the design of building fire safety, for which the derivation and justification are not explained. The present paper discusses the need for a transparent regulatory approach, in which legislators publicly justi

We live in a time of wireless technologies, robotics and small computers with very high computing power. This is mainly due to a large emphasis given towards the study of semiconductor materials which are the building blocks of today's electronic industry. One of the secrets behind creating faster computers is the ability to integrate more and more transistors on a small semiconductor chip. GordonThis thesis studies the role of interaction between charged particles for transport and optical properties in nanostructures. Simulations are provided for a quantitative description of the system dynamics probed by either current spectroscopy or light absorption. In the first part of the thesis (Part I) the basic theories are described and in the second part of the thesis (Part II) the papers list

How do joint measures of premorbid cognitive ability and familial cognitive aptitude (FCA) reflect risk for a diversity of psychiatric and substance use disorders? To address this question, we examined, using Cox models, the predictive effects of school achievement (SA) measured at age 16 and FCA—assessed from SA in siblings and cousins, and educational attainment in parents—on risk for 12 major p

Improved understanding of the disease mechanisms underlying type 2 diabetes (T2D) is needed, and so are new treatments.A new T2D risk variant was recently identified in ADRA2A, which encodes the α2A-adrenergic receptor. The risk allele leads to receptor overexpression in β-cells that causes increased adrenergic signaling and impaired insulin secretion. We showed that the α2A-adrenergic receptor an

In recent years, there have been notable advances with the development of anticancer drugs including those targeting protein tyrosine kinases such as the c-Met receptor, which has been implicated in the development and progression of several cancers. However, despite such progress, drug resistance continues to be the single most important cause of cancer treatment failure, and understanding the me