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Mission and Cosmopolitan Mothering : Saving Armenian Mothers and Orphans, 1902-1947

This article discusses and analyzes mothering that crosses boundaries of care in spite of differences of nationality, culture and religion. Swedish missionary Alma Johansson was one of a remarkable number of women missionaries who volunteered as relief workers during the Armenian refugee crisis. These women missionaries were often seen as mothers who were ‘saving a whole generation’. The article s

A holistic approach to host-pathogen interactions : Detecting the large to unravel the small

Sepsis is one of the leading causes of mortality and morbidity in the world, and is an overreaction by the immune system due to pathogen invasion of the bloodstream. The interactions, particularly the protein interactions, between the host and pathogen are fundamental for the outcome of the disease. However, some of the protein interactions are unknown and those that are known have been studied as

Mixed-species associations can arise without heterospecific attraction

Despite widespread research on the interaction rules that drive group-living behavior in animals, little is known about the spatial self-organization of individuals in heterospecific groups. This has led to significant challenges in teasing apart the various mechanisms thought to underpin multispecies groups. One potentially useful approach for gaining an understanding of this process is to identi

First-time fathers experiences of their prenatal preparation in relation to challenges met in the early parenthood period : Implications for early parenthood preparation

Objective to describe first-time fathers experiences of their prenatal preparation in relation to challenges met in the early parenthood period. Design a qualitative study was conducted and data was analysed with a phenomenographical approach. Setting and participants 15 first-time fathers were recruited from three postnatal units in southern Sweden and interviewed approximately one month after th

Dietary rose hip exerts antiatherosclerotic effects and increases nitric oxide-mediated dilation in ApoE-null mice

Atherosclerosis is a disease in which atheromatous plaques develop inside arteries, leading to reduced or obstructed blood flow that in turn may cause stroke and heart attack. Rose hip is the fruit of plants of the genus Rosa, belonging to the Rosaceae family, and it is rich in antioxidants with high amounts of ascorbic acid and phenolic compounds. Several studies have shown that fruits, seeds and

Reduced cerebrospinal fluid concentration of interleukin-12/23 subunit p40 in patients with cognitive impairment

BackgroundThe role of inflammation in Alzheimer’s disease (AD) and other cognitive disorders is unclear. In a well-defined mono-center population, we measured cytokines and chemokines in paired serum and cerebrospinal fluid (CSF) samples. MethodsConsecutive patients with AD (n = 30), stable mild cognitive impairment (SMCI, n = 11), other dementias (n = 11), and healthy controls (n = 18) were inclu

Postgrowth and Wellbeing : Challenges to Sustainable Welfare

This book presents a detailed and critical discussion about how human wellbeing can be maintained and improved in a postgrowth era. It highlights the close links between economic growth, market capitalism, and the welfare state demonstrating that, in many ways, wellbeing outcomes currently depend on the growth paradigm. Here the authors argue that notions of basic human needs deserve greater empha

Prospective temporal validation of mathematical models to calculate risk of endometrial malignancy in patients with postmenopausal bleeding

Objectives: To validate prospectively five mathematical models published in 2007 for calculating the risk of endometrial malignancy in a defined high-risk group of patients with postmenopausal bleeding and sonographic endometrial thickness≥4.5mm. Methods: Of 1012 consecutive patients, 379 fulfilled our inclusion criteria, which were the same as those of the original study in which the models were

Neurophysiological recovery 5 years after carpal tunnel release in patients with diabetes

Introduction: The long-term results of neurophysiological recovery after carpal tunnel release in patients with diabetes have not been studied. Methods: Thirty-five patients with diabetes and carpal tunnel syndrome (CTS) were matched with 31 patients without diabetes who had idiopathic CTS, and 27 and 30 patients, respectively, participated in this follow-up study. Nerve conduction results at 5 ye

Role of the axonal initial segment in psychiatric disorders : function, dysfunction, and intervention

The progress of developing effective interventions against psychiatric disorders has been limited due to a lack of understanding of the underlying cellular and functional mechanisms. Recent research findings focused on exploring novel causes of psychiatric disorders have highlighted the importance of the axonal initial segment (AIS), a highly specialized neuronal structure critical for spike initi

Glycomic and transcriptomic response of GSC11 glioblastoma stem cells to STAT3 phosphorylation inhibition and serum-induced differentiation

A glioblastoma stem cell (GSC) line, GSC11, grows as neurospheres in serum-free media supplemented with EGF (epidermal growth factor) and bFGF (basic fibroblast growth factor), and, if implanted in nude mice brains, will recapitulate high-grade glial tumors. Treatment with a STAT3 (signal transducer and activator of transcription 3) phosphorylation inhibitor (WP1193) or 10% FBS (fetal bovine serum

Comparative evaluation of four bacteria-specific primer pairs for 16S rRNA gene surveys

Bacterial taxonomic community analyses using PCR-amplification of the 16S rRNA gene and high-throughput sequencing has become a cornerstone in microbiology research. To reliably detect the members, or operational taxonomic units (OTUs), that make up bacterial communities, taxonomic surveys rely on the use of the most informative PCR primers to amplify the broad range of phylotypes present in up-to

The protagonist projection hypothesis

The protagonist projection hypothesis was formulated by Holton (1997) in order to account for cases where the speaker seems to utter contradictory statements. Holton argues that in these cases the speaker projects herself into the mind of someone else. Three different sentence-types have been classified as examples of protagonist projection: (i) sentences with factive verbs (tell+wh, know), (ii) s

On the complexity of screening detected abdominal aortic aneurysms : A retrospective observational multicenter cohort study

BACKGROUND: Ultrasound screening for abdominal aortic aneurysms (AAA) has been shown to decrease aneurysm related mortality. Likely by providing an opportunity to intervene while the aneurysm is still intact, but possibly also when and the anatomy still relatively uncomplicated which would provide a less complex procedure. Our aim was to retrospectively investigate the complexity of repair for scr

Germline heterozygous variants in genes associated with familial hemophagocytic lymphohistiocytosis as a cause of increased bleeding

Familial hemophagocytic lymphohistiocytosis (FHL) is caused by biallelic variants in genes regulating granule secretion in cytotoxic lymphocytes. In FHL3–5, the affected genes UNC13D, STX11 and STXBP2 have further been shown to regulate the secretion of platelet granules, giving rise to compromised platelet function. Therefore, we aimed to investigate platelet degranulation in patients heterozygou

Plant-pollinator networks in semi-natural grasslands are resistant to the loss of pollinators during blooming of mass-flowering crops

Mass-flowering crops lead to spatial redistributions of pollinators and to transient shortages within nearby semi-natural grasslands, but the impacts on plant-pollinator interactions remain largely unexplored. Here, we characterised which pollinator species are attracted by oilseed rape and how this affected the structure of plant-pollinator networks in nearby grasslands. We surveyed 177 networks