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Current genetic research on obsessive-compulsive disorder (OCD) supports contributions to risk specifically from common single nucleotide variants (SNVs), along with rare coding SNVs and small insertion-deletions (indels). The contribution to OCD risk from rare copy number variants (CNVs), however, has not been formally assessed at a similar scale. Here we describe an analysis of rare CNVs called
Despite the availability of new drugs on the clinics in recent years, drug-resistant epilepsy remains an unresolved challenge for healthcare, and one-third of epilepsy patients remain refractory to anti-seizure medications. Gene therapy in experimental models has emerged as effective treatment targeting specific neuronal populations in the epileptogenic focus. When combined with an external chemic
Intrinsic luminescence in Ce-doped (Lu,Y)2SiO5 (or LYSO:Ce) single crystals have been studied by means of excitation luminescence spectroscopy in the vacuum ultraviolet energy range under synchrotron radiation. A previously unreported luminescence band with emission at 250 nm has been discovered as well as its thermal behavior was described in the temperature range 10–120 K. The excitation spectra
Background/Objectives: Recent decades have witnessed a sharp increase in research investigating the association between hearing loss and cognitive impairment. Few previous studies have stratified for sex when investigating this issue, where results were inconsistent and require further clarification. Thus, the objective was to investigate the association between self-reported hearing loss and leve
Multiplanetary systems spanning the radius valley are ideal testing grounds for exploring the different proposed explanations for the observed bimodality in the radius distribution of close-in exoplanets. One such system is HIP 29442 (TOI-469), an evolved K0V star hosting two super-Earths and one sub-Neptune. We observed HIP 29442 with CHEOPS for a total of 9.6 days, which we modelled jointly with
Digital technologies are changing social work practices in profound ways. Today, digital devices are used by social workers in their everyday work; from assessing social benefit applications digitally, writing pre-formatted investigations and using chatrooms in treatment, to holding digital meetings with colleagues and clients. Digital technology is also utilized as a management instrument. Changi
Background: Multicentre studies have previously reported on national outcomes of surgery for primary hyperparathyroidism, but not investigated whether management and outcome are uniform among countries. This study investigated whether there are differences among European countries in operative management and outcome of surgery for primary hyperparathyroidism. Methods: Using data from Eurocrine®, a
The EU’s Common Agricultural Policy (CAP) has been broadened over recent decades in response to evolving challenges faced by the EU and its farmers. It now claims to support not only food security and farmers’ incomes, but also transitioning to a green economy, conservation of biodiversity and climate action. We have evaluated to what extent four main types of CAP payment instruments form a cohesi
The aim of the project is to investigate the possibility of using people's mobile phones to locate people in a tunnel environment using the mobile phone's Wi-Fi connection. In total, 39 different trials were carried out under different conditions in a road tunnel in Stockholm, Sweden. In the trials, the Wi-Fi-based predicted location has been compared with the actual location of the recruited 16 p
Objectives The study aimed to describe the experiences of physicians, nurses and psychologists employed in primary care in using digital video consultations. The second objective was to study the association between the predictors of behaviour and behavioural intentions to use digital consultations and to relate underlying behavioural beliefs to experiences of digital consultations in primary care
Objectives To develop a protocol for largescale analysis of synovial fluid proteins, for the identification of biological networks associated with subtypes of osteoarthritis. Methods Synovial Fluid To detect molecular Endotypes by Unbiased Proteomics in Osteoarthritis (STEpUP OA) is an international consortium utilising clinical data (capturing pain, radiographic severity and demographic features)
Transport in open quantum systems can be explored through various theoretical frameworks, including the quantum master equation, scattering matrix, and Heisenberg equation of motion. The choice of framework depends on factors such as the presence of interactions, the coupling strength between the system and environment, and whether the focus is on steady-state or transient regimes. Existing litera
The production of prompt Ds+ and D+ mesons is measured by the LHCb experiment in proton-lead (pPb) collisions in both the forward (1.5
The streaming instability is a mechanism whereby pebble-sized particles in protoplanetary discs spontaneously come together in dense filaments, which collapse gravitationally to form planetesimals upon reaching the Roche density. The extent of the filaments along the orbital direction is nevertheless poorly characterised, due to a focus in the literature on small simulation domains where the behav
INTRODUCTION: Providing medical advice regarding lifestyle changes is currently the most effective intervention for delaying dementia onset among individuals with subjective cognitive decline (SCD). Adherence to such advice can be influenced by individual's social environment. We measured that impact within a Latinamerican population. METHODS: We recruited 183 SCD individuals from a Memory Clinic,
BACKGROUND: Recent advancements in Alzheimer's disease (AD) biomarker research and clinical trials prompt reflection on the value and consequently appropriate use of tau positron emission tomography (tau-PET) in the future. METHODS: We conducted an online survey among dementia and PET experts worldwide to investigate the anticipated future role of tau-PET in clinical practice and trials. RESULTS:
The major histocompatibility complex (MHC) is central in adaptive immunity, with the highly polymorphic MHC genes encoding antigen-presenting molecules. Two MHC class II (MHC-II) loci, DA1 and DA2, predate the radiation of extant birds and persist throughout much of the avian phylogeny. Within each locus, the MHC-II molecules are encoded by A-genes (DAA) and B-genes (DAB), which are arranged in A–
This study examines the role of the Sovereign ESG framework in assessing national progress toward Transformative Change (TC) via environmental, social, and governance metrics. Using data from the World Bank Sovereign ESG Data Portal, we conduct an empirical explorative quantitative study and analyze ESG development across country income groups to identify sustainability challenges and opportunitie
