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Towards Catchment Scale Natural Flood Management : Developing Evidence, Funding and Governance Approaches

Natural flood management is emerging as a viable way to leverage ecological services to manage flooding. Stakeholders are progressively positioning natural flood management at the scale of river catchments to encourage a move beyond localised and opportunistic actions towards more strategic and cost-effective flood risk management responses. This reflects a broader turn towards nature-based soluti

Economic inequality and the ecological footprint: Time-varying estimates for four developed economies, 1962–2021

This paper explores the link between income, and wealth inequality and the ecological footprint in France, Netherlands, United States, and United Kingdom from 1962 to 2021. Based on theoretical considerations, we allow the relationship to vary over time. Our analysis provides some support for income inequality influencing ecological footprints, specifically through carbon emissions. Yet, we do notThis paper explores the link between income, and wealth inequality and the ecological footprint in France, Netherlands, United States, and United Kingdom from 1962 to 2021. Based on theoretical considerations, we allow the relationship to vary over time. Our analysis provides some support for income inequality influencing ecological footprints, specifically through carbon emissions. Yet, we do not

Vardagliga offentliga rum, torg och platser

Denna text visar att det offentliga rummet fyller många viktiga funktioner, och är en viktig demokratisk fråga. Olika människor har olika stort behov av de resurser som det offentliga rummet har att erbjuda, samtidigt som möjligheten till mobilitet ocksåvarierar. En större ensidighet hos offentliga platser minskar den grad av tillgänglighet som dessa platser kan erbjuda. Om det däremot finns förut

Prognostic and Predictive Factors in Early Alzheimer's Disease : A Systematic Review

Background: Alzheimer's disease (AD) causes progressive decline of cognition and function. There is a lack of systematic literature reviews on prognostic and predictive factors in its early clinical stages (eAD), i.e., mild cognitive impairment due to AD and mild AD dementia. Objective: To identify prognostic factors affecting eAD progression and predictive factors for treatment efficacy and safet

Geometry-Dependent Elastic Flow Dynamics in Micropillar Arrays

Regular device-scale DNA waves for high DNA concentrations and flow velocities have been shown to emerge in quadratic micropillar arrays with potentially strong relevance for a wide range of microfluidic applications. Hexagonal arrays constitute another geometry that is especially relevant for the microfluidic pulsed-field separation of DNA. Here, we report on the differences at the micro and macr

Migratory CD103+CD11b+ cDC2 cells in Peyer's patches are critical for gut IgA responses following oral immunization.

Induction and regulation of specific intestinal IgA responses critically depend on dendritic cell subsets and the T cells they activate in the Peyer's patches (PP). We found that oral immunization with cholera toxin (CT) as an adjuvant resulted in migration-dependent changes in the composition and localization of PP DC subsets with increased numbers of CD103 - cDC2s and LysoDCs in the subepithelia

Gravitational waves from composite dark sectors

We study under which conditions a first-order phase transition in a composite dark sector can yield an observable stochastic gravitational-wave signal. To this end, we employ the Linear-Sigma model featuring Nf = 3, 4, 5 flavours and perform a Cornwall-Jackiw-Tomboulis computation also accounting for the effects of the Polyakov loop. The model allows us to investigate the chiral phase transition i

Polymorphisms in Intron 1 of HLA-DRA Differentially Associate with Type 1 Diabetes and Celiac Disease and Implicate Involvement of Complement System Genes C4A and C4B

Polymorphisms in genes in the human leukocyte antigen (HLA) class II region comprise the most important inherited risk factors for many autoimmune diseases including type 1 diabetes (T1D) and celiac disease (CD): both diseases are positively associated with the HLA- DR3 haplotype (DRB1*03:01-DQA1*05:01-DQB1*02:01). Studies of two different populations have recently documented that T1D susceptibili

Human Leukocyte Antigen Signatures as Pathophysiological Discriminants of Microscopic Colitis Subtypes

Background and Aims: Microscopic colitis [MC] is currently regarded as an inflammatory bowel disease that manifests as two subtypes: collagenous colitis [CC] and lymphocytic colitis [LC]. Whether these represent a clinical continuum or distinct entities is, however, an open question. Genetic investigations may contribute important insight into their respective pathophysiologies. Methods: We conduc

EEG Frequency Correlates with α2-Receptor Density in Parkinson’s Disease

Introduction: Increased theta and delta power and decreased alpha and beta power, measured with quantitative electroencephalography (EEG), have been demonstrated to have utility for predicting the development of dementia in patients with Parkinson’s disease (PD). Noradrenaline modulates cortical activity and optimizes cognitive processes. We claim that the loss of noradrenaline may explain cogniti

Degrowth: A Path to Transformative Solutions for Socio-Ecological Sustainability

This article highlights the potential of degrowth as a transformative approach that can expand capacities necessary for socio-ecological sustainability. By addressing economic growth as a fundamental driver of unsustainability, degrowth offers a concrete pathway towards achieving sustainable outcomes. It calls for sustainability scientists to explicitly consider the role of economic growth, aligni

Predicting intensive care need in women with preeclampsia using machine learning–a pilot study

Background: Predicting severe preeclampsia with need for intensive care is challenging. To better predict high-risk pregnancies to prevent adverse outcomes such as eclampsia is still an unmet need worldwide. In this study we aimed to develop a prediction model for severe outcomes using routine biomarkers and clinical characteristics. Methods: We used machine learning models based on data from an i

Pressure-Related Effects on Homeostatic Müller Cell Proteins in the Adult Porcine in Vitro Retina

Purpose: To explore early pressure-related effects on Müller cell homeostatic proteins in the in vitro adult porcine retina. Methods: Retinal explants were subjected to 0-, 10-, 30-, or 60-mmHg of pressure for 24 or 48 h in culture. Retinal explants fixed immediately after enucleation were used as controls. Müller cell proteins were evaluated by GFAP, GS, CRALBP, and bFGF immunohistochemistry. Res

Interactions between vascular burden and amyloid-β pathology on trajectories of tau accumulation

Cerebrovascular pathology often co-exists with Alzheimer’s disease pathology and can contribute to Alzheimer’s disease-related clinical progression. However, the degree to which vascular burden contributes to Alzheimer’s disease pathological progression is still unclear. This study aimed to investigate interactions between vascular burden and amyloid-β pathology on both baseline tau tangle load an

Mediational pathways between aggregate genetic liability and nonfatal suicide attempt : A Swedish population-based cohort

Despite recent progress in the genetics of suicidal behavior, the pathway by which genetic liability increases suicide attempt risk is unclear. We investigated the mediational pathways from family/genetic risk for suicide attempt (FGRSSA) to suicide attempt by considering the roles of psychiatric illnesses. In a Swedish cohort, we evaluated time to suicide attempt as a function of FGRSSA and the m

“What about me?” : lived experiences of siblings living with a brother or sister with a life-threatening or life-limiting condition

Background: There is a lack of knowledge regarding siblings’ experiences of being a brother or sister of a child with a life-threatening or life-limiting condition. Siblings’ perspectives are often expressed through their parents and not by siblings themselves. Method: This study has a qualitative design within hermeneutic phenomenology. Thirteen siblings (ages 3–29) of children with cancer or gen

Incidence of injury and illness at the Beijing 2022 Paralympic Winter Games held in a closed-loop environment : A prospective cohort study of 7332 athlete days

Objective: To describe the epidemiology of injuries and illnesses sustained during the Beijing 2022 Paralympic Winter Games, organised in a closed-loop environment to adhere with COVID-19 restrictions. Methods: Injuries and illnesses from all teams were recorded on a daily basis by team medical staff on a web-based form and by local organising committee medical (polyclinic) facilities and venue me