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Type II collagen without adjuvant induces eosinophilic arthritis.
Eosinophilia is a characteristic feature of many inflammatory diseases including inflammatory bowel disease and asthma. It also occurs in a subtype of rheumatoid arthritis but the role of eosinophils has been unclear and animal models have been lacking. Here, we introduce a new mouse model to study the role of eosinophilia in arthritis. Intraperitoneal injection of type II collagen alone, without
Corporate interests as an obstacle to the primary prevention of cancer
BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter
BCL11 genes play crucial roles in lymphopoiesis and have been associated with hematopoietic malignancies. Specifically, disruption of the BCL11B (B-cell chronic lymphocytic leukemia/lymphoma 11B) locus is linked to T-cell acute lymphoblastic leukemia, and the loss of heterozygosity in mice results in T-cell lymphoma. BCL11 proteins are related C2H2 zinc-finger transcription factors that act as tra
The endocardial extent of reperfused first-time myocardial infarction is more predictive of pathologic Q waves than is infarct transmurality: a magnetic resonance imaging study.
Historically, Q-wave myocardial infarction (MI) has been equated with transmural MI. This association have, however, recently been rejected. The endocardial extent of MI is another potential determinant of pathological Q waves, since the first part of the QRS complex where the Q wave appears reflects depolarization of subendocardial myocardium. Therefore, the aim of the present study was to test t
Analysis of Swedish male breast cancer family data : a simple way to incorporate a common sibling effect
Based on a population-based cohort study, Olsson et al. [1993] found significant evidence for elevated incidence of breast and ovarian cancers among female first-degree relatives of men with breast cancer. Using an extension of logistic regressive models we investigate whether, after allowing for multifactorial familial correlations, single locus segregation could be the cause of the elevated inci
Women's View of Trust and its Influence on Entrepreneurship and Career Development
Parents' detection of early signs in their children having an autistic spectrum disorder
cThe study aimed to describe parents’ views of their early perception and detection that something was wrong with their child and to give a comprehensive description of early signs to help primary health care nurses to focus on relevant symptoms. Participants were 66 parents from a total of 37 families, a population-based sample from a Swedish county. Interview data were analyzed by manifest conte
Postnatal appearance of 5-HT2A receptors on fast flexor and slow extensor rat motor neurons
Motor neurons to the slowly contracting extensor soleus muscle in behaving rats begin to fire tonically in the 2nd week after birth. In the adult, tonic firing becomes predominant and appears to arise from plateau potentials under monoaminergic control. In the present work, motor neurons to slowly contracting extensor soleus and rapidly contracting extensor digitorum longus, a physiological flexor
Hollow implants in soft tissues allowing quantitative studies of cells and fluid at the implant interface
In order to study the early cellular response in the fluid phase found close to implants in soft tissues, an experimental method using a hollow implant was developed. The fluid present in an interior chamber communicating with the exterior of the implant was analysed. Polymorphonuclear granulocytes (PMNGs) were predominant during the study (1-9 days). In titanium implants a slight increase in cell
A comprehensive nomenclature for serine proteases with homology to tissue kallikreins.
Gels of hydrophobically modified hydroxyethyl cellulose cross-linked by amylose. Competition with cyclodextrin
Previous work has shown that amylose (AM) can cross-link hydrophobically modified polymers by inclusion complexation, whereby thermoreversible cold-setting gels are formed. In this work, the competition between AM and cyclodextrin (CD) for the formation of inclusion complexes with hydrophobically modified hydroxyethyl cellulose (HMHEC) is investigated. A detailed study of viscosity, NMR self-diffu
From Theory to Practice. Temporary International Presence in Hebron
This article examines the role of third parties in asymmetric conflicts and international peacekeeping in theory and practice. Various theoretical conceptualisations of peacekeeping are critically discussed and linked to conflict and negotiation theory. It argues that peacekeeping is a broad, transformative and context-dependent notion, highlighted by alterable meanings of impartiality, use of for
Asymmetric dinuclear metal complexes as models for active sites in hydrolases and redox enzymes
Recent advances in the synthesis of biomimetic asym. dinuclear transition metal complexes are reviewed. Emphasis is put on description of asym. model complexes for the active sites of the enzymes purple acid phosphatase, zinc phosphotriesterase, urease, Cu, Zn superoxide dismutase, tyrosinase, and catechol oxidase.
Glucose-induced incretin hormone release and inactivation are differently modulated by oral fat and protein in mice.
Monounsaturated fatty acids, such as oleic acid (OA), and certain milk proteins, especially whey protein (WP), have insulinotropic effects and can reduce postprandial glycemia. This effect may involve the incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). To explore this, we examined the release and inactivation of GIP and GLP-1 after administ
Deletion Rate Evolution and Its Effect on Genome Size and Coding Density
Deletion rates are thought to be important factors in determining the genome size of organisms in nature. Although it is indisputable that deletions, and thus deletion rates, affect genome size, it is unclear how, or indeed if, genome size is regulated via the deletion rate. Here, we employ a mathematical model to determine the evolutionary fate of deletion rate mutants. Simulations are employed t
Wrong biochemistry results - Information on incidents with consequences for health should be collected centrally
Fascicles do not have to be static structures
Fungal growth and effects of different wood decomposing fungi on the indigenous bacterial community of polluted and unpolluted soils
Thirty-two different basidiomycete isolates were inoculated separately into contaminated soil and the soil colonization ability was assessed visually. Large differences in the colonization ability and growth patterns were found between the different fungi. Phospholipid fatty acids (PLFAs) were extracted from the soils of the seven isolates with the best colonizing ability. All PLFAs that were not
Population dynamic consequences of delayed life-history effects
Evidence from wildlife and human populations indicates that conditions during early development can have marked effects on the subsequent performance of individuals and cohorts. Likewise, the effects of maternal and, more generally, parental environments can be transferred among individuals between generations. These delayed life-history effects are found consistently and suggestions have been mad