We developed an inbred rat model of diabetic embryopathy, in which the offspring displays skeletal malformations (agnathia or micrognathia) when the mother is diabetic, and no malformations when she is not diabetic. Our aim was to find genes controlling the embryonic maldevelopment in a diabetic environment. We contrasted the fetal outcome in inbred Sprague-Dawley L rats (20% skeletal malformation

Falling in old age may have a large impact on daily life. Falls can lead to injuries, reduced mobility and reduced quality of life. The risk of falls increases with age and frailty level. Dizziness is a strong risk factor for falls, and preventing falls and dizziness in older people is essential. The overall aim of this thesis was to investigate risk factors for falls or dizziness and to explore o

Interest in the generation of biogas from agricultural residues is increasing rapidly due to its climate benefits. In this study, an evaluation of the economic feasibility of various technologies, also on different scales, for the production of combined heat and power from manure-based biogas in Sweden is presented. The overall conclusion is that such production is not profitable under current con

The effect of three different types of polymer chain structures on the polymer release from hydrophilic matrix tablets was investigated by comparing a synthetic semi-crystalline linear polymer (PEO), a branched amorphous polysaccharide (dextran) and an amorphous substituted cellulose derivative (HPMC). The polymer release rates for tablets containing mixtures of high and low molecular weight grade

Background and Purpose-Genetic variation influences risk of intracerebral hemorrhage (ICH). Hypertension (HTN) is a potent risk factor for ICH and several common genetic variants (single nucleotide polymorphisms [SNPs]) associated with blood pressure levels have been identified. We sought to determine whether the cumulative burden of blood pressure-related SNPs is associated with risk of ICH and p

Policies for regional innovation in Sweden rely on the view that different groups of actors enter into collaboration on the basis of a mutual interest. One recent organisational expression of this view is the development of innovation policy and development organisations known as 'Arenas'. These organisations were modelled on the Triple Helix innovation theory, which is known for promoting innovat

Background/Objectives:Data on associations between marine n-3 fatty acids and glucose metabolism are inconsistent. Therefore, we explored effects of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor (PPAR)-gamma2 gene on associations of fish intake and dietary and plasma eicosapentaenoic and docosahexaenoic acid with glucose metabolism. The design comprises of the cross-secti

Purpose – The purpose of this paper is to provide a paradigmatic reflection on theoreticalapproaches recently identified in logistics and supply chain management (SCM); namely complex adaptive systems and complexity thinking, and to compare it to the dominant approach in logistics and SCM research, namely the systems approach. By analyzing the basic assumptions of the three approaches, SCM and log

Achieving asthma control remains an elusive goat for the majority of patients worldwide. Ensuring a correct diagnosis of asthma is the first step in assessing poor symptom control; this requires returning to the basics of history taking and physical examination, in conjunction with lung function measurement when appropriate. A number of factors may contribute to suboptimal asthma control. Concomit

Arteriosclerosis with its clinical sequelae (cardiac infarction, stroke, peripheral arterial occlusive disease) and vascular/Alzheimer dementia not only result in far more than half of all deaths but also represent dramatic economic problems. The reason is, among others, that diabetes mellitus is an independent risk factor for both disorders, and the number of diabetics strongly increases worldwid

Popular Abstract in Swedish Befolkningsutvecklingen i Sverige medför att allt fler människor blir äldre. Detta är ett positivt resultat till följd av att befolkningen är vid bättre hälsa. Dock innebär det att fler människor kommer att uppnå en ålder där multisjuklighet (att ha flera kroniska sjukdomar samtidigt), oförmåga att klara sig själv och kognitiv svikt är vanligt förekommande. Detta kommerBackground: People aged over 80 years is the most rapidly growing segment of the population in Sweden. This group is susceptible to multimorbidity, disability and cognitive impairment. Managing these issues will be essential in order to obtain a sustainable healthcare system in the near future. Aim: To determine if increased acknowledgement of cognitive impairment could improve healthcare for el

A minimal food web model was constructed comprising one grazing and one detritus food chain coupled by nutrient cycling and generalist carnivores to investigate how prey preference by carnivores may affect the strength of trophic cascades across a gradient of nutrient enrichment. The equilibrium or mean abundance of each food web component and the magnitude of the carnivore effect on lower trophic

We extend a newly introduced framework for the simulation of shape memory alloys undergoing martensite-austenite phase-transformations by allowing for the evolution of individual plastic deformations in each phase considered. The goal is to obtain a generalised model which will facilitate the reflection of the characteristic macroscopic behaviour of SMA as well as TRIP steels. Particularly, we sho

OBJECTIVE: The purpose of the study was to determine the prevalence and factors associated with injury in professional ballet and modern dancers, and assess if dancers are reporting their injuries and explore reasons for not reporting injuries. DESIGN: Cross-sectional study. SETTING: Participants were recruited from nine professional ballet and modern dance companies in Canada, Denmark, Israel,

Heritable and visually detectable polymorphisms, such as trophic polymorphisms, ecotypes, or colour morphs, have become classical model systems among ecological geneticists and evolutionary biologists. The relatively simple genetic basis of many polymorphisms (one or a few loci) makes such species well-suited to study evolutionary processes in natural settings. More recently, polymorphic systems h

In order to improve biological control of agricultural pests, it is fundamental to understand which factors influence the composition of natural enemies in agricultural landscapes. In this study, we aimed to understand how agricultural land use affects a number of different traits in ground beetle communities to better predict potential consequences of land-use change for ecosystem functioning. We

The ground state of frustrated (antiferromagnetic) triangular molecular magnets is characterized by two total-spin S = 1/2 doublets with opposite chirality. According to a group theory analysis [M. Trif et al., Phys. Rev. Lett. 101, 217201 (2008)], an external electric field can efficiently couple these two chiral spin states, even when the spin-orbit interaction (SOI) is absent. The strength of t