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A case of dermatofibrosarcoma protuberans with a ring chromosome 5 and a rearranged chromosome 22 containing amplified COL1A1 and PDGFB sequences

Dermatofibrosarcoma protuberans (DFSP) is a cutaneous tumour of borderline malignancy, the cytogenetic features of which include the translocation t(17;22)(q22;q13) or, more commonly, supernumerary ring chromosomes containing material from 17q22 and 22q13. These rearrangements result in the COL1A1/PDGFB fusion gene. Here, we describe a case of DFSP displaying a ring chromosome 5 together with a la

Forecasting incoming call volumes in call centers with recurrent Neural Networks

Researchers apply Neural Networks widely in model prediction and data mining because of their remarkable approximation ability. This study uses a prediction model based on the Elman and NARX Neural Network and a back-propagation algorithm for forecasting call volumes in call centers. The results can help determine the optimal number of agents necessary to reduce waiting time for customers, enablin

Complementary shifts in photoreceptor spectral tuning unlock the full adaptive potential of ultraviolet vision in birds

Color vision in birds is mediated by four types of cone photoreceptors whose maximal sensitivities (λmax) are evenly spaced across the light spectrum. In the course of avian evolution, the λmax of the most shortwave-sensitive cone, SWS1, has switched between violet (λmax > 400 nm) and ultraviolet (λmax < 380 nm) multiple times. This shift of the SWS1 opsin is accompanied by a corresponding short-w

System simulations of a 1.5 V SiGe 81-86 GHz E-band transmitter

This paper presents simulation results for a sliding-IF SiGe E-band transmitter circuit for the 81-86 GHz E-band. The circuit was designed in a SiGe process with fT = 200 GHz and uses a supply of 1.5 V. The low supply voltage eliminates the need for a dedicated transmitter voltage regulator. The carrier generation is based on a 28 GHz quadrature voltage oscillator (QVCO). Upconversion to 84 GHz is

From Demonstrations to Skills for High-level Programming of Industrial Robots

In this paper we describe our approach to robotic skill representation and a prototypical implementation of a programming-by-demonstration approach that allows users to generate skills and robot program primitives for later re- finement and re-use. We intend to evaluate the applicability of this approach to high-level programming in a user study, which we also explain.

Recent developments in the ABINIT software package

ABINIT is a package whose main program allows one to find the total energy, charge density, electronic structure and many other properties of systems made of electrons and nuclei, (molecules and periodic solids) within Density Functional Theory (DFT), Many-Body Perturbation Theory (GW approximation and Bethe-Salpeter equation) and Dynamical Mean Field Theory (DMFT). ABINIT also allows to optimize

Mariyamma and the logic of realist explanation in sociology

Realism as a theory of science, in the view of the author of this paper, provides elegant solutions to several puzzles and dilemmas, not only in philosophy, but also to some of the most fundamental theorerical and methodological problems in social science. This paper introduces scien­tific realism, and presents one way of applying it to social science.

Housing in an enriched environment : A tool to study functional recovery after experimental stroke

Physical therapy and social interactions between the stroke patient and health-care professionals or relatives facilitate the process of recovery and promote improvement of lost neurological function after stroke. These observations can be mimicked in an experimental setting by multimodal stimulation provided in the concept of enriched environment. The enriched environment is a housing condition f

Gephyrin Cleavage in In Vitro Brain Ischemia Decreases GABAA Receptor Clustering and Contributes to Neuronal Death

GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the central nervous system, and changes in GABAergic neurotransmission modulate the activity of neuronal networks. Gephyrin is a scaffold protein responsible for the traffic and synaptic anchoring of GABAA receptors (GABAAR); therefore, changes in gephyrin expression and oligomerization may affect the activity of GABAergic syna

Housing in an enriched environment : A tool to study functional recovery after experimental stroke

Physical therapy and social interactions between the stroke patient and health care professionals or relatives facilitate the process of recovery and promote the improvement of neurological function after stroke. These observations can be mimicked in the experimental setting with the concept of enriched environment. The enriched environment is a housing condition for rodents combining social inter

Report of a consensus meeting on human brain temperature after severe traumatic brain injury : Its measurement and management during pyrexia

Temperature disturbances are common in patients with severe traumatic brain injury. The possibility of an adaptive, potentially beneficial role for fever in patients with severe brain trauma has been dismissed, but without good justification. Fever might, in some patients, confer benefit. A cadre of clinicians and scientists met to debate the clinically relevant, but often controversial issue abou

Protein Kinase C-γ and Calcium/Calmodulin-Dependent Protein Kinase II-α Are Persistently Translocated to Cell Membranes of the Rat Brain during and after Middle Cerebral Artery Occlusion

The levels of protein kinase C-γ (PKC-γ) and the calcium/calmodulin-dependent kinase II-α (CaMKII-α) were measured in crude synaptosomal (P2), particulate (P3), and cytosolic (S3) fractions of the neocortex of rats exposed to 1-hour and 2-hour middle cerebral artery occlusion (MCAO) and 2-hour MCAO followed by 2-hour reperfusion. During MCAO, PKC levels increased in P2 and P3 in the most severe is