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Novel risk genes for systemic lupus erythematosus predicted by random forest classification

Genome-wide association studies have identified risk loci for SLE, but a large proportion of the genetic contribution to SLE still remains unexplained. To detect novel risk genes, and to predict an individual's SLE risk we designed a random forest classifier using SNP genotype data generated on the "Immunochip" from 1,160 patients with SLE and 2,711 controls. Using gene importance scores defined b

Sensitivity of Sentinel-1 backscatter to characteristics of buildings

In this study, Sentinel-1 interferometric wide swath (IW) mode backscatter is analysed with respect to physical parameters of buildings in Tallinn, Estonia. Dependence on height, alignment, density, shape, and material is shown and discussed. Distribution of backscatter was estimated with respect to each of the parameters, and a correlation matrix of all physical parameters and backscatter values

A finite deformation continuum modelling framework for curvature effects in fibre-reinforced nanocomposites

Motivated by experimental findings on one-dimensional nano-materials, this contribution focusses on the elaboration of a fibre curvature based higher-order gradient contribution to the stored energy function in a finite deformation setting. The presented approach is based on the fundamental theoretical developments for fibre-reinforced composites presented by Spencer and Soldatos (2007), which tak

Bare and Effective Charge of Mesoporous Silica Particles

We develop and combine a novel numerical model, within the Poisson-Boltzmann framework, with classical experimental titration techniques for mesoporous silica particles to study the charging behavior as both pH and the amount of monovalent salt are varied. One key finding is that these particles can be considered to have an effectively or apparent electroneutral inner core with an effectively char

Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates

The coaggregation of the amyloid-β peptide (Aβ) and α-synuclein is commonly observed in a range of neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases. The complex interplay between Aβ and α-synuclein has led to seemingly contradictory results on whether α-synuclein promotes or inhibits Aβ aggregation. Here, we show how these conflicts can be rationalized and resolved by de

Two dynamin-like proteins stabilize FtsZ rings during Streptomyces sporulation

During sporulation, the filamentous bacteria Streptomyces undergo a massive cell division event in which the synthesis of ladders of sporulation septa convert multigenomic hyphae into chains of unigenomic spores. This process requires cytokinetic Z-rings formed by the bacterial tubulin homolog FtsZ, and the stabilization of the newly formed Z-rings is crucial for completion of septum synthesis. He

Implementation of a multiplexed structured illumination method to achieve snapshot multispectral imaging

An instantaneous multispectral imaging setup based on frequency recognition algorithm for multiple exposures (FRAME) is presented and demonstrated experimentally. With this implementation of FRAME, each light source is uniquely encoded with a spatial modulation and the corresponding fluorescent responses pertaining to each maintain the same unique encoding. This allows the extraction of each sourc

Modeling the role of highly oxidized multifunctional organic molecules for the growth of new particles over the boreal forest region

In this study, the processes behind observed new particle formation (NPF) events and subsequent organic-dominated particle growth at the Pallas Atmosphere-Ecosystem Supersite in Northern Finland are explored with the one-dimensional column trajectory model ADCHEM. The modeled sub-micron particle mass is up to ∼75 % composed of SOA formed from highly oxidized multifunctional organic molecules (HOMs

Proteomic Expression Changes in Large Cerebral Arteries After Experimental Subarachnoid Hemorrhage in Rat Are Regulated by the MEK-ERK1/2 Pathway

Subarachnoid hemorrhage (SAH) is a serious clinical condition where leakage of blood into the subarachnoid space causes an acute rise in intracranial pressure and reduces cerebral blood flow, which may lead to delayed cerebral ischemia and poor outcome. In experimental SAH, we have previously shown that the outcome can be significantly improved by early inhibition of the MAPK/ERK kinase/extracellu

Doctors Doing Gender at Eye Clinics—Gender Constructions in Relation to Waiting Times for Cataract Extractions in Sweden

Why do eye clinics differ in their waiting times for women’s and men’s access to cataract extraction (CE)/“grå starroperation”? Taking a doing-gender perspective as the starting point, this study explores how gender constructions embedded in Swedish eye clinics contribute to longer waiting times for women than for men. Focus group interviews were conducted with doctors at two Swedish eye clinics:

Combined analyses of costs, market value and eco-costs in circular business models : eco-efficient value creation in remanufacturing

Eco-efficient Value Creation is a method to analyse innovative product and service design together with circular business strategies. The method is based on combined analyses of the costs, market value (perceived customer value) and eco-costs. This provides a prevention-based single indicator for ‘external environmental costs’ in LCA. The remanufacturing of products is an environmental and sustain

A thermal design method for the performance optimization of multi-stream plate-fin heat exchangers

An optimization design method based on field synergy principle is developed for Multi-stream plate-fin heat exchangers (MPHEs) with a segmented differential model. The heat exchanger is divided into a number of sub-exchangers along the main stream, and each sub-exchanger consists of N passages along the height of the exchanger. Compared with the traditional heat exchanger design, this method allow

Palmitoylation of Ca2+ channel subunit CaVβ2a induces pancreatic beta-cell toxicity via Ca2+ overload

High blood glucose triggers the release of insulin from pancreatic beta cells, but if chronic, causes cellular stress, partly due to impaired Ca2+ homeostasis. Ca2+ influx is controlled by voltage-gated calcium channels (CaV) and high density of CaV in the plasma membrane could lead to Ca2+ overload. Trafficking of the pore-forming CaVα1 subunit to the plasma membrane is regulated by auxiliary sub

Non-linear FE-Analysis of stress redistribution in a deep beam

Design of discontinuity regions in reinforced concrete is today often performed with Strut and Tie Method (STM) or linear finite element analyses (LFEA). However, it is questionable to what extent these design methods are appropriate with regard to resistance, ductility, serviceability and economic reinforcement arrangement. In design with STM a simple equilibrium model based on plasticity theory

Practical bond model for corroded RC bridges

Corrosion of steel reinforcement is a common cause of deterioration in reinforced concrete bridges and many existing bridges are damaged to varying degrees. The rate of deterioration of the bridge stock has been shown to increase due to climate change. Unsympathetically, the demand for load-carrying capacity is however often increased with time. Therefore there is an increasing need for reliable m

Age but not Philadelphia positivity impairs outcome in older/elderly patients with acute lymphoblastic leukemia in Sweden

Objectives: Older/elderly patients with acute lymphoblastic leukemia (ALL) are poorly represented in clinical trials. Methods: Using Swedish national leukemia registries, we investigated disease/patient characteristics, treatment choices, outcome, and the impact of an age-adapted protocol (introduced in 2009) in this population-based study of patients aged 55-85 years, diagnosed with ALL 2005-2012

New results related to QGP-like effects in small systems with ALICE

Results on the production of π±, K±, p(p), Λ(Λ), Ξ- (Ξ+) and Ω- (Ω+) at midrapidity (/y/ < 0.5) as a function of multiplicity in √ s = 7 TeV pp collisions are reported. Transverse momentum distributions and integrated yields are compared to expectations from statistical hadronization models along with results from different colliding systems and center-of-mass energies. The evolution of spectral s