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The aim of this thesis is develop methods to extract information from high-dimensionality data and to apply them in looking at gene-gene and gene-protein interactions in Acute Myeloid Leukemia (AML). The in silico methods developed can be used with data from other systems. The thesis gives an overview of the field for network inference and deconvolution methods, as well as a brief background on th
Group-based microfinance programmes, based on trust and solidarity among members, currently dominate development policy and practice as the approach compensates for individual poor’s lack of material resources and market imperfections. Despite strong evidence of its social and economic impact, few researches take an in-depth, empirical look at how the group models manifest and create social capita
The road safety development in East-European countries follows in general the trends of the western countries, even though there is a time lag. The fatality numbers are decreasing, though the improvements for the vulnerable road users are less impressive compared to other road user categories. The traditional road safety analysis based on accident history has many limitations related to accident u
Disease-modifying treatments remain an unmet medical need in Parkinson's disease (PD). Such treatments can be operationally defined as interventions that slow down the clinical evolution to advanced disease milestones. A treatment may achieve this outcome by either inhibiting primary neurodegenerative events ("neuroprotection") or boosting compensatory and regenerative mechanisms in the brain ("ne
It discusses some media writing that monitor some violations and turn a blind eye to others in Yemen.
Slab reheating characteristics in the walking beam type reheating furnace were studied by using the finite volume method (FVM). A geometry model for simulating the gas circulation, heat transfer and slabs reheating process in a reheating furnace was developed by using ANSYS FLUENT software. Usually, slabs are heated in the furnace, and temperature values of the slabs reach above 1,500 K. After tha
Usually, turbine blades operate under a harsh environmental condition. The inlet temperature of gas turbines increases with an improvement of the engine efficiency. Some cooling schemes are adopted to prevent the blades from thermal erosion of the hot mainstream. Film cooling technology is used widely and effectively in the blade cooling. In this paper, a comparison of hole blockage configurations
Cryogels have potential for applications in water and wastewater treatment. However, maximum levels of exposure to both incorporated materials in cryogels (i.e., nanoparticles [NPs]) and monomers, as a result of leakage, must be established before cryogel composites can be implemented in the large-scale treatment of water. Other factors, such as cost and reuse, must also be studied for each specif
Low energy buildings have well insulated building enclosures and efficient ventilation heat recovery systems which lead to small transmission and ventilation heat losses. During a large part of the year internal heat gains from people, household electricity and solar heat gains balance the heat losses with zero heating need as a result. All energy uses in a building are part of the buildings energ
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När vi börjar tala om personer/grupper som vänner eller fiender påverkas också vår benägenhet att handla utifrån dessa språkval. Därför blir det obehagligt när Springare svepande, utan exempel, skriver att han vill ”förinta alla de vänsterextrema journalister som förpestar debatten med sina abnorma agendor
With a specific emphasis on the imperial durbar as symbolic form and ritual content, the paper explores how the British, until 1857 in the guise of the East India Company, drew on and gradually adjusted local customs and notions of rightful authority as part of their annexation and subjection of South Asian polities. The paper suggests that the the imperial durbars of 1877, 1903 and 1911, as well
Participation of stakeholders at the local level is evolving as a mechanism to address complex environmental problems, not least water pollution. Participation has been used as a tool for the economic and social empowerment of settlements within the catchment of the Korle lagoon in Ghana, particularly residents of the Old Fadama community that live in proximity to the lagoon. Using direct observat
Isotopic proveniencing has been applied to human inhumations and cremations as well as fauna from the Viking Age site of Birka and the surrounding Mälaren region, located in east-central Sweden. Human enamel from inhumations has been measured for strontium, oxygen, and carbon isotope ratios (petrous bone from cremations was measured for strontium only) to obtain information on mobility and diet. SIsotopic proveniencing has been applied to human inhumations and cremations as well as fauna from the Viking Age site of Birka and the surrounding Mälaren region, located in east-central Sweden. Human enamel frominhumations has been measured for strontium, oxygen, and carbon isotope ratios (petrous bone from cremations was measured for strontium only) to obtain information on mobility and diet. Se
