The disease-linked amyloid beta (A beta) and alpha-synuclein (alpha S) proteins are both fibril-forming and natively unfolded in free monomeric form. Here, we discuss two recent studies, where we used extensive implicit solvent all-atom Monte Carlo (MC) simulations to elucidate the conformational ensembles sampled by these proteins. For alpha S, we somewhat unexpectedly observed two distinct phase

It is common practice in wastewater engineering to extend standard activated sludge models (ASMs) with extra process equations derived from batch experiments. However, such experiments have often been performed under conditions different from the ones normally found in wastewater treatment plants (WWTPs). As a consequence, these experiments might not be representative for full-scale performance, a

Myten analyseras som gestaltningar av klyvnaderna mellan ord och mening (språk och värld), kunskap och illusion, man och kvinna, jag och icke-jag. Det är klyvnader som kan hänföras till Platon.

Biological properties of connective tissues rely heavily on collagen and its use in formation of extracellular networks (matrices) in which cells can live and move. To regulate the process of collagen matrix assembly, the cells secrete small leucine-rich repeat proteoglycans (SLRPs) that bind to collagen and influence its fibril formation. In this manner, fibromodulin - one of the SLRPs - can alte

The angular distribution of photoelectrons ejected during the ionization of Ne atoms by extreme ultraviolet (XUV) free-electron laser radiation in the presence of an intense near infrared (NIR) dressing field was investigated experimentally and theoretically. A highly nonlinear process with absorption and emission of more than ten NIR photons results in the formation of numerous sidebands. The amp

This article focuses on expressions of bereavement and religious coping in medieval miracle stories from Sweden. The stories come from the collections of St. Birgitta (Bridget) of Sweden, the Blessed Bishop Nicolaus Hermanni (Sw. Nils Hermansson) of Linköping and the Blessed Katarina of Vadstena, and were recorded in the fourteenth and fifteenth centuries. Catherine M. Sanders’s modern five stages

Pathogenic fungi represent a major threat particularly to immunocompromised hosts, leading to severe, and often lethal, systemic opportunistic infections. Although the impaired immune status of the host is clearly the most important factor leading to disease, virulence factors of the fungus also play a role. Factor H (FH) and its splice product FHL-1 represent the major fluid phase inhibitors of t

Risk factors for stroke are well known in atrial fibrillation (AF) patients, while less is known on the effect of these factors on total mortality. Our aim was to study the impact of cardiovascular drug classes on mortality in AF patients treated in primary care. The study population was chosen based on patient data from 75 primary care centres in Sweden compiled in a database. Individuals diagnos

Background. This study aimed to evaluate Pediatric Appendicitis Score (PAS), diagnostic delay, and factors responsible for possible late diagnosis in children

Diabetes Mellitus is a chronic disease characterized by the inability of the organism to autonomously regulate the blood glucose level due to insulin deficiency or resistance, leading to serious health damages. The therapy is essentially based on insulin injections and depends strongly on patient daily decisions, being mainly based upon empirical experience and rules of thumb. The development of a

A particle-based transported probability density function (PDF) method with a novel chemistry acceleration technique is developed in this work. The technique is based on the chemistry coordinate mapping (CCM) approach that was proposed in our previous works for accelerating direct numerical simulations (DNS) of partially premixed combustion. The method is first validated using Sandia flames D and

A coherent pulse generator for implementation in an impulse radio system is presented. It accurately transforms a 12.5 GHz square wave input signal to 33 ps long 60 GHz pulses. The wavelets are generated through direct conversion from base-band to 60 GHz by switching a negative differential conductance oscillator on and off. The slope of the input signal determines the phase, which is either I+ or

We develop the case for symmetrical assumptions in strategic management theory. Assumptional symmetry obtains when assumptions made about certain actors and their interactions in one of the application domains of a theory are also made about this set of actors and their interactions in other application domains of the theory. We argue that assumptional symmetry leads to theoretical advancement by

Purpose - This paper has three purposes. The first is to introduce the concept of fantasy, based on Lacanian pyschoanlysis, in order to link theoretically the role of narrative and affect in organizational strategies of control. The second is to use this concept to illuminate the fantasmatic as well as ideological character of so-called "market rationality." The third is to reveal three dominant f

Arterial stiffness is an independent risk factor for cardiovascular morbidity and can be assessed by applanation tonometry by measuring pulse wave velocity (PWV) and augmentation index (AIX) by pressure pulse wave analysis (PWA). As an inexpensive and operator independent alternative, photoelectric plethysmography (PPG) has been introduced with analysis of the digital volume pulse wave (DPA) and i

Popular Abstract in Swedish Diabetes mellitus är en endokrin sjukdom. Hos friska individer producerar beta och alpha cellerna i bukspottkörteln insulin och glukagon, de viktigaste hormonerna för att reglera blodglukos¬koncentrationen. Insulin utsöndras som svar på förhöjda blodglukosnivåer. Hormonet minskar glukosproduktion från levern och ökar glukosupptaget samt dess användning och lagring i fetType 2 Diabetes (T2D) is a multifactorial disease, which has made it difficult to resolve its pathophysiology. We investigated processes that could contribute to the development of T2D. In addition to well-known hallmarks of the disease, such as defective insulin secretion, insulin resistance and perturbed glucagon secretion, we aimed to find a possible role for CLOCK genes in the pathogenesis of

The semantic formalism reference attribute grammars (RAGs) allows graphs to be superimposed on abstract syntax trees. This paper investigates how RAGs can be used to model visual languages, with a case study of a control language that also has a textual syntax. The language contains blocks on which a total execution order is defined based on connections and layout information. One strength of RAGs