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Adding hydrogen atoms and protonation states to structures of membrane proteins requires successful implementation of neutron macromolecular crystallography (NMX). This information would significantly increase our fundamental understanding of the transport processes membrane proteins undertake. To grow the large crystals needed for NMX studies requires significant amounts of stable protein, but on
The development of neutralizing antibodies is a rare complication of von Willebrand disease treatment. In major surgical procedures for severe forms of the disease, the recognition of ineffective therapy and alternative treatment protocols are lifesaving. We report the case of a 6-year-old girl with type 3 von Willebrand disease in whom inhibitors were sought due to ineffective haemostasis togethe
The country reports deal with the regulation of international direct-to-participant genomic research.
Background: Generally considered benign, electrocardiographic (ECG) early repolarization (ER) pattern was claimed to be an indicator of increased susceptibility to ventricular arrhythmias during acute ischemia. Objective: The purpose of this study was to assess in a nonselected population whether ER pattern documented before ST-elevation myocardial infarction (STEMI) is associated with risk of hem
... en personal ville kasta en burk bearnaisesås i huvudet på mig ...... då kom det skitmånga personal och bara brotta ned oss, alltså fy fan ... ... alltså konflikter kommer vi inte undan, så enkelt är det ...I "Vanskligt och kort" analyserar författaren fem händelser från vardagen på särskilda ungdomshem i Sverige, en välkänd plats för många ungdomar med kriminella erfarenheter och psykosociala
This article explores the politics behind the promise of ‘blue growth’. Reframing it as a ‘blue fix’, we argue that the blue growth discourse facilitates new opportunities for capital accumulation, while claiming that this accumulation is compatible with social and ecological aims as well. The blue fix is made up of three underlying sub-fixes. First of all, the conservation fix quenches the social
Reduced emissions and environmental burden from shipping are an important aim of tightening emission regulations and ambitious climate change strategy. Renewable methanol produced from biomass or from other renewable sources represents one option to face these challenges. We studied the potential of renewable methanol to offer such benefits in diesel operation in a Scania ethanol engine, which is
MOTIVATION: Massively parallel reporter assays (MPRA) enable systematic screening of DNA sequence variants for effects on transcriptional activity. However, convenient analysis tools are still needed. RESULTS: We introduce MPRAscore, a novel tool to infer allele-specific effects on transcription from MPRA data. MPRAscore uses a weighted, variance-regularized method to calculate variant effect size
BACKGROUND AND OBJECTIVES: Changes in teachers' work situation in Sweden since the 1990s may have contributed to an increase in common mental disorders (CMDs) and burnout. However, there is a lack of research in this field. The aim was to describe how Swedish elementary school teachers experience their health, organizational and social work environment, and the psychosocial safety climate at the w
Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underlying risk remain largely unknown. These regions were explored by combining association analysis with in silico genomic feature annotations. We defined 205 independent risk-associated signals with the set of credible causal variants in each one. In parallel, we used a Ba
In the 1990s the world economy was hit by a series of unusually deep crises with far-reaching consequences, the first of which occurred in Finland and Sweden. This paper compares the cost of the crisis of the 1990s with the costs caused by all major crises and depressions since the 1870s in the two Nordic countries. First, it constructs a crisis chronology for Finland and Sweden. Second, it estima
This report estimates possible macroeconomic effects of a pandemic taking place in the EU in 2006, using a quarterly macroeconomic model. The macroeconomic costs of a pandemic, that is the cost in terms of production lost due to illness and death measured as reductions in GDP growth and/or declines in the level of GDP, are quantified in various pandemic scenarios. We focus on two sectors of the Eu
