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Detailed statistical analysis plan for the target temperature management after out-of-hospital cardiac arrest trial

Background: Animal experimental studies and previous randomized trials suggest an improvement in mortality and neurological function with temperature regulation to hypothermia after cardiac arrest. According to a systematic review, previous trials were small, had a risk of bias, evaluated select populations, and did not treat hyperthermia in the control groups. The optimal target temperature manag

Multimodal constructions in children : is the headshake part of language?

Swedish children’s use of the headshake from 18 to 30 months shows a developmental progression from rote-learned coordination with speech to increasingly more flexible and productive coordination with speech. To deal with these observations, I introduce the concept of multimodal constructions in order to extend usage-based approaches to language learning and construction grammar into the kinetic d

Prediction of Postoperative Pain After Mandibular Third Molar Surgery

Aims: To evaluate the predictive potential of preoperative psychological and psychophysiological variables in estimating severity of postoperative pain following mandibular third molar surgery (MTMS). Methods: Following ethical committee approval and informed consent, 40 consecutive patients scheduled for MTMS were included. Preoperative psychometric indicators of anxiety, depression, and vulnerab

Ordovician polychaeturid polychaetes: Taxonomy, distribution and palaeoecology

The fossil polyclinic family Polychaeturidae is considered as monogeneric and comprises four species of the genus Pteropelta. Pteropelta, originally established on isolated scolecodonts (the carriers), is revised and the apparatus-based Polychaetura is shown to be a junior synonym of Pteropelta. In addition to Pteropelta gladiata and Pteropelta kielanae. Pteropelta huberti sp. nov., and Pteropelta

Entrepreneurship research in China: internationalization or contextualization?

Entrepreneurship is an emerging research field that has received much scholarly attention in recent decades. Given the global scope of this attention, this article compares entrepreneurship research in China with that in the USA and Europe. Based on publications in Social Science Citation Index and Chinese Social Science Citation Index databases over the past 10 years, we use bibliometric method t

Family and School Psychosocial Environment (FSPE): Development of a brief questionnaire measuring perceived psychosocial environments in children/siblings

Persson, B. (2011). Family and School Psychosocial Environment (FSPE): Development of a brief questionnaire measuring perceived psychosocial environments in children/siblings. Scandinavian Journal of Psychology. The aim of the study was to develop a short Swedish standardized, factor analyzed and cross-validated, family and school psychosocial environment questionnaire (FSPE). The study was based

Effects on heart pumping function when using foam and gauze for negative pressure wound therapy of sternotomy wounds

Background: Negative pressure wound therapy (NPWT) has remarkable effects on the healing of poststernotomy mediastinitis. Foam is presently the material of choice for NPWT in this indication. There is now increasing interest in using gauze, as this has proven successful in the treatment of peripheral wounds. It is important to determine the effects of NPWT using gauze on heart pumping function bef

Deteriorated function of cutaneous microcirculation in chronic congestive heart failure

Background Chronic congestive heart failure is a complex condition that leads to dysfunction in the peripheral microcirculation. We have previously shown that vascular reactivity is reduced with increasing age. In this study, we examined a group of very old patients with severe chronic heart failure to test the hypothesis that vascular function is further compromised by a combination of heart fail

Dectin-1 and DC-SIGN Polymorphisms Associated with Invasive Pulmonary Aspergillosis Infection

The recognition of pathogen-derived structures by C-type lectins and the chemotactic activity mediated by the CCL2/CCR2 axis are critical steps in determining the host immune response to fungi. The present study was designed to investigate whether the presence of single nucleotide polymorphisms (SNPs) within DC-SIGN, Dectin-1, Dectin-2, CCL2 and CCR2 genes influence the risk of developing Invasive

Causes of premature mortality in Swedish drug abusers: A prospective longitudinal study 1970-2006.

Aims To evaluate premature mortality and causes of death from young adulthood to middle age in a cohort of drug users followed during almost four decades Design Follow-up study of a consecutive cohort of patients with drug abuse/dependence. Methods A cohort of 561 drug abusers, admitted to a detoxification and short-term rehabilitation unit 1970–1978 was followed to December 31st, 2006. Standard

Presynaptic calcium signalling in cerebellar mossy fibres

Whole-cell recordings were obtained from mossy fibre terminals in adult turtles in order to characterize the basic membrane properties. Calcium imaging of presynaptic calcium signals was carried out in order to analyse calcium dynamics and presynaptic GABA B inhibition. A tetrodotoxin (TTX)-sensitive fast Na+ spike faithfully followed repetitive depolarizing pulses with little change in spike dura

Hydrogen analysis and profiling with a position sensitive detector

The double sided silicon strip detector (DSSSD) is a segmented silicon detector commonly used in the fields of high energy physics and nuclear physics. This type of detector is used for analysis of reactions produced by charged particles. This makes it well suited for a number of analytical methods commonly used in ion beam analysis (IBA), such as Rutherford Backscattering (RBS) and elastic recoil

Mitochondrial function in sepsis - Temporal evolvement of respiratory capacity in human blood cells

Popular Abstract in Swedish Allt liv på jorden är beroende av energi. Växter och vissa bakterier kan fånga och utnyttja solens energi för att bygga upp sina celler och dess delkomponenter som fetter, sockerarter och proteiner. Den energi som på så sätt blir bunden i dessa molekyler kan användas av djur och människor genom att vi konsumerar dem. För att energin skall kunna utnyttjas av kroppen måstSepsis is a devastating disease that is caused by the host’s response to an overwhelming infectious process. As sepsis progresses, organs distant from the site of infection become affected and sepsis-induced multiple organ failure ensues. An impaired immunologic response, including dysfunctional peripheral blood immune cells has been described as part of the septic syndrome. Mitochondrial dysfunct