OBJECTIVE: To study the effects of the hypertonic solutions 15% mannitol, 3% and 7.5% saline, and 30% urea at clinically relevant plasma concentrations with regard to absorption and rebound effects on tissue volume in skeletal muscle. DESIGN: A prospective, experimental study. SETTING: University laboratory. SUBJECTS: Twenty-eight anesthetized cats. INTERVENTIONS: The study was performed on an aut

Sulfation of all macromolecules entering the secretory pathway in higher organisms occurs in the Golgi and requires the high-energy sulfate donor adenosine 3'-phosphate 5'-phosphosulfate. Here we report the first molecular identification of a gene that encodes a transmembrane protein required to transport adenosine 3'-phosphate 5'-phosphosulfate from the cytosol into the Golgi lumen. Mutations in

A low-phase-noise low-phase-error 1.8 GHz quadrature CMOS VCO was presented. The VCO with three metal layers showed -140 dBc/Hz or less phase noise across an 18% tuning range while drawing 25 mA from a 2 V power supply. The VCO showed high phase-noise figure-of-merit and low phase-error.

Popular Abstract in Swedish Överdosens antropologi behandlar narkotikaöverdosens sociala konsekvenser. Eva-Malin Antoniusson har studerat hur olika aktörer i vård- och institutionsmiljöer förhåller sig till överdoser. Forskningen bygger på fältundersökningar i Sverige, USA och Nederländerna. I avhandlingen återges intervjuer med narkomaner som överlevt överdoser eller varit med när andra överdoserThe central theme of this thesis is the nature of heavy drug overdose and its social consequences. The aim of the study is to provide a nuanced ethnographic interpretation on the phenomenon concerning drug overdose, especially among drug users using injections as the principle means of administering the drugs. The field study was localized to institutional milieus, primarily drug addiction treatme

During the last decade several long term studies of interventions in patients with COPD have been published. This review analyses the potential of these interventions to alter the progression of the condition. The only treatment that has unequivocally been shown to reduce the rate of decline in FEV(1) is smoking cessation. Active psychological intervention in combination with pharmacotherapy is re

The structural organization of the gene for the human cysteine-proteinase inhibitor cystatin C was studied. Restriction-endonuclease digests of human genomic DNA hybridized with human cystatin C cDNA and genomic probes produced patterns consistent with a single cystatin C gene and, also, the presence of six closely related sequences in the human genome. A 30 kb restriction map covering the genomic

A method using a model-based approach to design and optimize an ion-exchange step in a protein purification process is proposed for the separation of IgG from a mixture containing IgG, BSA and myoglobin. The method consists of three steps. In the first step, the model is calibrated against carefully designed experiments. The chromatographic model describes the convective and dispersive flow in the

Survey data on breeding wader densities and grazing intensity on coastal meadows on the Baltic island of Öland from 1988, 1998 and 2003 were used to evaluate density and density-changes of four common and widespread wader species, lapwing Vanellus vanellus, redshank Tringa totanus, oystercatcher Haematopus ostralegus and ringed plover Charadrius hiaticula in relation to grazing intensity. Populati

A systematic review of radiation therapy trials in several tumour types was performed by The Swedish Council of Technology Assessment in Health Care (SBU). The procedures for evaluation of the scientific literature are described separately (Acta Oncol 2003; 42: 357-365). This synthesis of the literature on radiation therapy for soft tissue sarcomas (STS) is based on data from five randomized trial

Twenty-six patients were operated because of osteo-arthritis of the trapeziometacarpal joint. After excision of the trapezium, they were randomized to receive either a Swanson silicone trapezium implant or a tendon interposition arthroplasty using a strip of the abductor pollicis longus tendon (APL). No infection or clinical silicone synovitis occurred and no major radiographic cyst formation was

Background. Shipment of pancreata between distant centers is frequently associated with prolonged cold ischemia time (CIT) that leads to poorer outcomes for islet transplantation. Clinical pilot trials have indicated that oxygenation of explanted human pancreata utilizing the two-layer method (TLM) allows the use of marginal donor pancreata for islet transplantation. The present study aimed to cla

Amyloid-beta peptide (A) and the serpin proteinase inhibitor 1-antichymotrypsin (ACT) are components of the amyloid plaques associated with Alzheimer's disease (AD). A exists in soluble monomeric and oligomeric forms and in an insoluble polymerised fibrillar form, but it is not clear which of these plays the most important role in the etiology of AD. In vitro, A1-42 interacts with ACT, and as a re

Twenty-eight names of taxa of Hieracium, occuring in, and in most cases described on the basis of material from, the SE Swedish provinces of Gotland and Ostergotland are lectotypified.

A premature boy who had suffered from IRDS, bronchopulmonary dysplasia and retinopathy of prematurity developed massive hypertriglyceridemia (48.1 mmol/L) together with moderate hypercholesterolemia (12.6 mmol/L) at 5 months of age. Lipoprotein electrophoresis revealed a marked elevation of the level of the very low density lipoprotein fraction. There was a moderate decrease in the activity of a l