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Next-generation sequencing techniques have revealed that leukemic cells in acute myeloid leukemia often are characterized by a limited number of somatic mutations. These mutations can be the basis for the detection of leukemic cells in follow-up samples. The aim of this study was to identify leukemia-specific mutations in cells from patients with acute myeloid leukemia and to use these mutations a

Background: The Scandinavian society of anaesthesiology and intensive care medicine task force on pre-hospital airway management was asked to formulate recommendations following standards for trustworthy clinical practice guidelines. Methods: The literature was systematically reviewed and the grading of recommendations assessment, development and evaluation (GRADE) system was applied to move from

This paper uses the cloud resolving Active Tracer High-resolution Atmospheric Model coupled to the interactive surface model Hybrid in order to investigate the diurnal development of a lake-breeze system at the Nam Co Lake on the Tibetan Plateau. Simulations with several background wind speeds are conducted, and the interaction of the lake breeze with topography and background wind in triggering m

To investigate the energy, matter and reactive and non-reactive trace gas exchange between the atmosphere and a spruce forest in the German mountain region, two intensive measuring periods were conducted at the FLUXNET site DE-Bay (Waldstein-Weidenbrunnen) in September/October 2007 and June/July 2008. They were part of the project "ExchanGE processes in mountainous Regions" (EGER). Beyond a brief

The mainobjective of this paper is to challenge the treatment of first-person epistemicand evidential complement-taking predicate (CTP) constructions in Martin andWhite’s (2005) appraisal theory,and to offer suggestions for improving the model. Based on empirical evidencefrom a corpus-based analysis and a laboratory experiment, we demonstrate that CTPconstructions do not only serve to expand the d

Clinical studies have shown NOAC to be at least as safe and effective as warfarin, with a lower frequency of intracranial bleeds. To use them to their full potential, a good organisation with knowledgeable and interested medical staff, proper information to the patients to assure proper handling and compliance of the medications, as well as knowledge of how to handle treatment complications is imp

Ovarian cancer develops due to a complex interplay between hereditary and environmental factors. Although often described as one disease, ovarian cancer is actually a group of distinct tumor types. Recent research has indicated that a large percentage of ovarian cancers may originate from the fallopian tube epithelium. Although most cancers develop in patients without a known hereditary syndrome,