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An acetonic extract and secondary metabolites from the endolichenic fungus Nemania sp. EL006872 exhibit immune checkpoint inhibitory activity in lung cancer cell.

Background: Endolichenic fungi (ELF), which live the inside the lichen thallus, contain many secondary metabolites that show various biological activities. Recent studies show that lichen and ELF secondary metabolites have antioxidant, antibacterial, antifungal, cytotoxic, and anticancer activities. Purpose: Here, the effects of an ELF extract and its bioactive compounds were investigated on the

Investigating photomultiplier tube nonlinearities in high-speed phosphor thermometry using light emitting diode simulated decay curves

Photomultiplier tube (PMT) nonlinearities relevant for single shot high-speed lifetime phosphor thermometry were investigated by simulating decay curves with a light emitting diode (LED) at repetition rates between 1 Hz and 10 kHz. The PMT gain, LED decay time, and background radiant flux were also varied to investigate their impact on the measured decay time error. Errors in the measured decay tiPhotomultiplier tube (PMT) nonlinearities relevant for single shot high-speed lifetime phosphor thermometry were investigated by simulating decay curves with a light emitting diode (LED) at repetition rates between 1 Hz and 10 kHz. The PMT gain, LED decay time, and background radiant flux were also varied to investigate their impact on the measured decay time error. Errors in the measured decay ti

Automated Phosphor Thermometry Lifetime Calibration of Multiple Phosphors and Emission Lines to above 1900 K

A method is specified which enables lifetime calibration of multiple phosphors and emission lines at the same time to temperatures above 1900 K. The experimental setup and algorithm used for data collection and experimental equipment control are described. The phosphors were coated on an alumina oxide disc and the reference temperature was measured using three type B thermocouples. The algorithm a

The Swedish Racial Welfare Regime in Transition

A weakness in research on welfare regimes is that solidarity and deservingness has often been analysed unidimensional in relation to a capitalist class-structured society. Feminist and postcolonial scholars have argued that welfare regimes need to be situated and analysed in an intersectional setting. In this chapter, focussing on Sweden, a central contention is that in analysing welfare provision

Detection of lymph node metastases in patients with prostate cancer : Comparing conventional and digital [18F]-fluorocholine PET-CT using histopathology as a reference

Background: Positron emission tomography-computed tomography (PET-CT) with [18F]-fluorocholine (FCH) is used to detect and stage metastatic lymph nodes in patients with prostate cancer. Improvements to hardware and software have recently been made. We compared the capability of detecting regional lymph node metastases using conventional and digital silicon photomultiplier (SiPM)-based PET-CT techn

Patient trajectories after diagnosis of diffuse large B-cell lymphoma—a multistate modelling approach to estimate the chance of lasting remission

Background: Achieving lasting remission for at least 2 years is a good indicator for favourable prognosis long term after Diffuse large B-cell lymphoma (DLBCL). The aim of this study was to provide real-world probabilities, useful in risk communication and clinical decision-making, of the chance for lasting remissions by clinical characteristics. Methods: DLBCL patients in remission after primary

International experience makes a difference: Effects of studying abroad on students' self-efficacy

The present study examined whether students experience an increase in their general perceived self-efficacythrough international academic mobility. Two hundred and twenty-one students at Leuphana UniversityLüneburg were enrolled in a test-retest study with two points of measurement including a time interval of ap-proximately six months. Perceived self-efficacy was measured in a group of sojourners

International sojourn experience and personality development: Selection and socialization effects of studying abroad and the Big Five

As part of a multi-study project, this test-retest study seeks to identify the relations between studying abroad anda sojourner's personality as measured by the Big Five personality traits. It thereby attempts to answer the ques-tions of who chooses to study abroad and how study abroad changes personality. A total of 221 students from aGermanuniversity weretracked over the courseofa semester, with

Return to Sports : A Risky Business? A Systematic Review with Meta-Analysis of Risk Factors for Graft Rupture Following ACL Reconstruction

Background: The risk of sustaining a graft rupture after anterior cruciate ligament reconstruction (ACLR) is high. Contributing risk factors are, however, still not clearly identified. Objective: The aim of this systematic review was to identify and quantify risk factors for graft rupture after ACLR. Methods: A systematic review with meta-analysis (PROSPERO CRD42020140129) based on PRISMA guidelin

The Lund Molecular Taxonomy Applied to Non-Muscle-Invasive Urothelial Carcinoma

The precise classification of tumors into relevant molecular subtypes will facilitate both future research and optimal treatment. Here, the Lund Taxonomy system for molecular classification of urothelial carcinoma was applied to two large and independent cohorts of non-muscle-invasive tumors. Of 752 tumors classified, close to 100% were of the luminal subtypes, 95% urothelial-like (Uro; UroA, UroB

Medium development and production of carotenoids and exopolysaccharides by the extremophile Rhodothermus marinus DSM16675 in glucose-based defined media

Background: The marine thermophilic bacterium Rhodothermus marinus can degrade many polysaccharides which makes it interesting as a future cell factory. Progress using this bacterium has, however, been hampered by limited knowledge on media and conditions for biomass production, often resulting in low cell yields and low productivity, highlighting the need to develop conditions that allow studie

A novel membraneless β-glucan/O2 enzymatic fuel cell based on β-glucosidase (RmBgl3B)/pyranose dehydrogenase (AmPDH) co-immobilized onto buckypaper electrode

A novel membraneless β-glucan/O2 enzymatic fuel cell was developed by combining a bioanode based on buckypaper modified with co-immobilized Agaricus meleagris pyranose dehydrogenase (AmPDH) and Rhodothermus marinus β-glucosidase (RmBgl3B) (RmBgl3B-AmPDH/buckypaper) with a biocathode based on solid graphite modified with Myrothecium verrucaria bilirubin oxidase (MvBOx/graphite). AmPDH was connected

Massive star cluster formation and evolution in tidal dwarf galaxies

Context. The formation of globular clusters remains an open debate. Dwarf starburst galaxies are efficient at forming young massive clusters with similar masses as globular clusters and may hold the key to understanding their formation. Aims. We study star cluster formation in a tidal debris, including the vicinity of three tidal dwarf galaxies, in a massive gas-dominated collisional ring around N