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The multifaceted complement regulator vitronectin (Vn) can be found in almost all tissues of the human body. It is primarily produced by the liver and is thus detected at high concentrations in plasma. Upon inflammation, Vn is upregulated revealing its importance for the innate immune defence against danger signals. It consists of 459 amino acids and has several key sequences linked to its functio
Factor I (FI) is a serine protease with narrow specificity restricted to activated complement components C3b and C4b. Supported by appropriate cofactors such as factor H or C4b-binding protein, FI cleaves peptide bonds in C3b/C4b after arginyl residues. By doing so it inhibits further propagation of the complement cascade thus contributing to protection from misguided or excessive complement attac
C4b-binding protein (C4BP) is the main fluid-phase inhibitor of the classical complement pathway. It serves as cofactor in factor I-mediated cleavage of C4b and C3b and it accelerates the decay of complement convertases. The main role of C4BP is to prevent overt complement-mediated inflammation both in solution and on self-molecules recognised by C1q, such as amyloid. Furthermore, C4BP is frequent
This article investigates whether regime-based asset allocation can effectively respond to changes in financial regimes at the portfolio level in an effort to provide better long-term results when compared to a static 60/40 benchmark. The potential benefit from taking large positions in a few assets at a time comes at the cost of reduced diversification. The authors analyze this trade-off in a mul
Background: KIT mutations are the predominant driver mutations in gastrointestinal stromal tumors (GISTs), and targeted therapy against KIT has improved treatment outcome dramatically. However, gaining secondary mutation of KIT confers drug resistance of GISTs leading to treatment failure. Results: In this study, we found that secondary mutation of KIT dramatically increases the ligand-independent
Coronautbrottet är ett hot mot Sveriges nationella säkerhet. Det riskerar leda till en ökning av främmande makters aktiviteter, terrorattacker, organiserad brottslighet samt social oro, skriver Ardavan Khoshnood, specialistläkare, kriminolog och statsvetare.The corona eruption is a threat to Sweden's national security. It risks leading to an increase in the activities of foreign powers, terrorist attacks, organized crime and social unrest, writes Ardavan Khoshnood, specialist physician, criminologist and political scientist.
In my dissertation the method to describe semantic change used in the Swedish Academy dictionary (SAOB) is compared with cognitive semantic models of such a change. The work of SAOB is theoretically unbound in terms of overarching semantic theories, and the methods of describing word meaning and semantic change in the dictionary are rather developed for pragmatic reasons (such as consistency and e
