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Multilevel regression analysis (MLRA) is a statistical technique that is suitable for the study of correlated outcomes within multilevel organisational and other data structures. This chapter provides a short introduction to MLRA, stressing the multilevel analysis of individual heterogeneity and discriminatory accuracy (MAIHDA) approach. It helps the readers to recognize the presence of multilevel
Background:cThe risk of coronavirus (COVID-19) can be affected by the presence of certain chronic conditions. It is unknown if individuals with severe hereditary alpha-1-antitrypsin deficiency (AATD) faced an increased risk of severe COVID-19 infection during the pandemic and if COPD in this population affected the risk of severe COVID-19 outcomes. Aim: Our aim was to investigate COVID-19 outcomes
Older adults with intellectual disabilities are not adequately prepared for ageing and show anxiety and uncertainty regarding the future. Therefore, the two-year educational intervention "Good Life in Old Age" was implemented to improve their understanding of ageing and enhance their well-being. This study aimed to explore the meaning of ageing during and after the intervention from the perspectiv
The machine perfusion (MP) of transplantable grafts has emerged as an upcoming field in Cardiothoracic (CT) transplantation during the last decade. This technology carries the potential to assess, preserve, and even recondition thoracic grafts before transplantation, so it is a possible game-changer in the field. This technology field has reached a critical turning point, with a growing number of
Coronavirus disease 2019 (COVID-19) is a contagious disease that turned into a pandemic and led to seven million deaths around the globe. A herculean effort was made by world scientific community to develop various therapies including vaccines against COVID-19 in record time. Use of nanomedicine was one among the different treatment strategies tried against COVID-19. Nanocarriers were effectively
This chapter starts with a review of the theoretical foundation for understanding two-dimensional electronic spectroscopy (2DES) signals in molecular systems. We derive and motivate key properties of 2DES, demonstrating its ability to yield complex information about energy transfer processes and couplings within molecular assemblies, such as photosynthetic antennae. We continue with a discussion e
Interleukin-2 (IL-2) was one of the first cytokines discovered and its central role in T cell function soon led to the notion that the cytokine could specifically activate immune cells to combat cancer cells. Recombinant human IL-2 (recIL-2) belonged to the first anti-cancer immunotherapeutics that received marketing authorization and while it mediated anti-tumor effects in some cancer entities, t
We harness the complex mixing process inside a commercial multi-mode fibre to program high-dimensional linear optical circuits for photonic qudits encoded in transverse space and time-of-arrival, and demonstrate their use for high-dimensional entanglement certification.
Background: Over the past decade, the use of organophosphate insecticides including chlorpyrifos has faced increasing restrictions due to health concerns, leading to a rise in use of pyrethroids. Concerns about neurodevelopmental insults following pyrethroids exposure exist, but few studies have examined the long-term effects of childhood exposure to chlorpyrifos and pyrethroids on IQ. Objective:
Background: Higher circulating levels of tumor necrosis factor (TNF) alpha receptors 1 (TNFR1) and 2 (TNFR2) are associated with increased long-term mortality and impaired kidney function. Aim: To study associations between levels of TNFR1 and TNFR2 and all-cause mortality as well as estimated glomerular filtration rate (eGFR) decline. Population and methods: Patients with chronic kidney disease (
We evaluate deep learning architectures for rat pose estimation using a six-camera system, focusing on ResNet and EfficientNet across various depths and augmentation techniques. Among the configurations tested, ResNet 152 with default augmentation provided the best performance when employing a multi-perspective network approach in the controlled experimental setup. It reached a Root Mean Squared E
In the construction industry, projects are organized with many different subcontractors that carry out the day-to-day undertakings. There is generally a lack of skilled labour in the construction industry that makes construction lack productivity and become a dangerous workplace. Skilled subcontractors are a neglected group of potential innovators in this industry. The main reason why they are ver
Breast cancer is the most common type of cancer in women worldwide. Triple-negative breast cancer (TNBC) is a subtype of breast cancer that lacks the expression of the oestrogen receptor, progesterone receptor, and amplification of HER2. This subtype is the most aggressive subtype and a heterogeneous subgroup of breast cancer, making up around 10-15% of the cases, often affecting younger patients
Idiopathic pulmonary fibrosis (IPF) remains a challenging disease with no drugs available to change the trajectory. It is a condition associated with excessive and highly progressive scarring of the lungs with remodelling and extracellular matrix deposition. It is a highly "destructive" disease of the lungs. The diagnosis of IPF is challenging due to continuous evolution of the disease, which also
Language is a complex semiotic system based on the context-sensitive use of signs, in contrast to the comparatively rigid systems of signals used by other animals, making it a uniquely human bio-cultural adaptation. But equally unique for human beings are other semiotic systems, and their corresponding sociocultural practices, such as (representational) gesture, the use of pictures and music. Cruc
Background: The perspectives of children with life-threatening or life-limiting (LT/LL) conditions have predominantly been conveyed through their parents rather than heard from the children themselves. Despite an increase in studies focusing on children’s perspectives in pediatric palliative care, this research remains limited, particularly in including children who are unable to express themselve
"Nu är det höst! Vårterminen avslutades med den nationella högskolepedagogiska konferensen ”NU 2024”, som gick av stapeln vid Umeå universitet. Strax före midsommar samlades drygt 450 konferensdeltagare – lärare, doktorander, studentrepresentanter, akademiska ledare, pedagogiska utvecklare, IKT-pedagoger, bibliotekarier m.fl. – för att diskutera ”Högre utbildning i och för förändring”. Här fanns e
The last years of turbulence on the market caused by the pandemic and geo-political tensions have led to supply disruptions for many companies. The purpose of this study was to investigate how digital purchasing practices and trust are impacted in the supply chain due to increased turbulence in the environment. This was carried out through an interview study with buyers and sellers in supply chainThe last years of turbulence on the market caused by the pandemic and geo-political tensions have led to supply disruptions for many companies. The purpose of this study was to investigate how digital purchasing practices and trust are impacted in the supply chain due to increased turbulence in the environment. This was carried out through an interview study with buyers and sellers in supply chain
