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Fabrication of Tunnel FETs demonstrating sub-thermal subthreshold slope

Tunnel Field Effect Transistor (TFET), based on band-to-band tunneling, overcomes the thermal limit (subthreshold slope (S) > 60 mV/decade) of the MOSFETs by filtering the high-energy Fermi tail, thereby allowing a substantial reduction of supply voltage and power consumption. Despite the steep slope behavior, TFETs can suffer from ambipolarity wherein carriers tunnel into the channel at both high

Pharmacological characterization of AC-262536, a novel selective androgen receptor modulator

Because of the limitations and liabilities of current testosterone therapies, non-steroidal tissue-selective androgen receptor modulators may provide a clinically meaningful advance in therapy. Using a functional cell-based assay AC-262536 was identified as a potent and selective AR ligand, with partial agonist activity relative to the natural androgen testosterone. A 2-week chronic study in castr

Distribution of 5‐hydroxytryptamine (serotonin) in the brain of the teleost Gasterosteus aculeatus L.

The distribution of serotoninergic neurons in the brain of the three‐spined stickleback was demonstrated with the indirect peroxidase‐antiperoxidase (PAP) immunohistochemical method with antibodies against serotonin. Serotoninergic perikarya were demonstrated in the brainstem reticular formation (nucleus raphe dorsalis, nucleus raphe medialis, and nucleus tegmenti dorsalis lateralis) and in the pe

The Parapineal Organ of Teleosts

A parapineal organ was found to be present in 21 teleost fishes belonging to 20 different families, but was absent in poecilids and cyprinodontids. The parapineal organ was situated on the left side of the brain and sent a nerve tract to the left habenular nucleus, except in Gadus, where a “parapineal organ” appeared to send a nerve tract into the pineal stalk. The parapineal organ of adult Gaster

Electron microscopic analysis of S‐antigen‐ and serotonin‐immuoreactive neural and sensory elements in the photosensory pineal organ of the salmon

Photoreceptor cells in the pineal complex of poikilothermic vertebrates are regarded as homologous with the neuroendocrine pinealocytes in the mammalian pineal organ. They possess an indolamine metabolism, and they contain a number of substances that are immunochemically similar to phototransduction‐related proteins otherwise found in photoreceptors of the lateral eye retina. Using correlative lig

Mapping the terrain of disability and sexuality: from policy to practice

This paper is based on a lecture held in Nagoya, Japan as part of a seminar on issues relating to disabled women, sexuality and sexual and reproductive health and rights (SRHR). I present preliminary results from the research project Sexual Citizenship and Disability: Implications for Theory, Practice and Policy, which focuses on sexual rights for people with mobility impairments. The data compris

Low-temperature back-end-of-line technology compatible with III-V nanowire MOSFETs

We present a low-temperature processing scheme for the integration of either lateral or vertical nanowire (NW) transistors with a multilayer back-end-of-line interconnect stack. The nanowire device temperature budget has been addressed, and materials for the interconnect fabrication have been selected accordingly. A benzocyclobutene (BCB) polymer is used as an interlayer dielectric, with interconn

Människor, maskiner och framtidens arbete

En forskningsöversikt om arbetsfördelningen mellan människor och maskiner med inriktning på digitaliseringens och AI-utvecklingens effekter på framtidens arbetsmarknad och kompetensbehov.

Assessment of the appropriate use criteria for amyloid PET in an unselected memory clinic cohort : The ABIDE project

Introduction: The objective of this study was to assess the usefulness of the appropriate use criteria (AUC) for amyloid imaging in an unselected cohort. Methods: We calculated sensitivity and specificity of appropriate use (increased confidence and management change), as defined by Amyloid Imaging Taskforce in the AUC, and other clinical utility outcomes. Furthermore, we compared differences in p

The DNA damage response activates HPV16 late gene expression at the level of RNA processing

We show that the alkylating cancer drug melphalan activated the DNA damage response and induced human papillomavirus type 16 (HPV16) late gene expression in an ATM- and Chk1/2-dependent manner. Activation of HPV16 late gene expression included inhibition of the HPV16 early polyadenylation signal that resulted in read-through into the late region of HPV16. This was followed by activation of the exc

Statistical inference with deep latent variable models

Finding a suitable way to represent information in a dataset is one of the fundamental problems in Artificial Inelegance. With limited labeled information, unsupervised learning algorithms help to discover useful representations. One of the applications of such models is imputation, where missing values are estimated by learning the underlying correlations in a dataset. This thesis explores two ofFinding a suitable way to represent information in a dataset is one of the fundamental problems in Artificial Intelligence. With limited labeled information, unsupervised learning algorithms help to discover useful representations. One of the applications of such models is imputation, where missing values are estimated by learning the underlying correlations in a dataset. This thesis explores two

Ontogenetic development of the pineal organ, parapineal organ, and retina of the three-spined stickleback, Gasterosteus aculeatus L. (Teleostei) - Development of photoreceptors

The ontogenetic developments of the pineal organ, parapineal organ, and retina were studied by the use of light and electron microscopy in embryos and fry of the teleost, Gasterosteus aculeatus, from 60 to 168 h after fertilization. Sixty to 66 h after fertilization, the primordium of the pineal complex is discernible in the diencephalic roofplate; the parapineal anlage is located rostral to the p

Convection-enhanced delivery of temozolomide and whole cell tumor immunizations in GL261 and KR158 experimental mouse gliomas

BACKGROUND: Glioblastomas (GBM) are therapy-resistant tumors with a profoundly immunosuppressive tumor microenvironment. Chemotherapy has shown limited efficacy against GBM. Systemic delivery of chemotherapeutic drugs is hampered by the difficulty of achieving intratumoral levels as systemic toxicity is a dose-limiting factor. Although some of its effects might be mediated by immune reactivity, sy

På spaning efter den tid när bostadsrättsägare skyddades från flytt

När beneficieskyddet för bostadsrätter infördes i svensk rätt var lagstiftarens syfte att bostadsrätter som utgångspunkt skulle undantas utmätning. Sedan införandet har värdet på bostadsrätter stigit. Värdestegringen har varit avgörande för rättsutvecklingen och idag skyddas endast en förhållandevis liten andel av svenska bostadsrätter från utmätning genom beneficieregeln i 5 kap. 1 § första styck

Using Cards to Facilitate Conversations About Wishes and Priorities of Patients in Palliative Care

To avoid discomfort, health care professionals may hesitate to pursue conversations about end of life with patients. Certain tools have the potential to facilitate smoother conversations in this matter. The objective was to explore the experiences of patients in palliative care in using statement cards to talk about their wishes and priorities. Forty-six cards with statements of wishes and priorit