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The implementation of NILS : A web-based artificial neural network decision support tool for noninvasive lymph node staging in breast cancer

Objective: To implement artificial neural network (ANN) algorithms for noninvasive lymph node staging (NILS) to a decision support tool and facilitate the option to omit surgical axillary staging in breast cancer patients with low-risk of nodal metastasis. Methods: The NILS tool is a further development of an ANN prototype for the prediction of nodal status. Training and internal validation of the

Competing dynamics of intramolecular deactivation and bimolecular charge transfer processes in luminescent Fe(iii) N-heterocyclic carbene complexes

Steady state and ultrafast spectroscopy on [FeIII(phtmeimb)2]PF6 (phtmeimb = phenyl(tris(3-methylimidazol-2-ylidene))borate) was performed over a broad range of temperatures. The intramolecular deactivation dynamics of the luminescent doublet ligand-to-metal charge-transfer (2LMCT) state was established based on Arrhenius analysis, indicating the direct deactivation of the 2LMCT state to the doubl

Drivers of diatom production and the legacy of eutrophication in two river plume regions of the northern Gulf of Mexico

In the northern Gulf of Mexico (nGoM), the Louisiana Shelf (LS) and Mississippi Bight (MB) subregions are influenced by eutrophication to varying degrees. Despite recognition that dissolved silicon may regulate diatom productivity in the nGoM, there is only one published data set reporting biogenic silica (bSiO2) production rates for each subregion. We report that bSiO2 production rates on the LS

Transitioning from conventional photon therapy to proton therapy for primary brain tumors

Introduction: Proton radiation therapy (PT) has become a treatment option alongside photon therapy (XRT) for lower-grade gliomas (LGG). In this single-institution retrospective study, we investigate the patient characteristics and treatment outcomes, including pseudo-progression (PsP), for LGG patients selected for PT. Method: Adult patients with grade 2–3 glioma consecutively treated with radioth

Industrial Relations

The aim of this chapter is to present industrial relations as a field of research to labour law researchers, and to discuss current research topics and identify areas for future research. In doing so, the chapter will also explore questions such as: What may an industrial relations-perspective in labour law research entail? When is an industrial relations-perspective fruitful in labour law researc

Plasma protein biomarkers predict the development of persistent autoantibodies and type 1 diabetes 6 months prior to the onset of autoimmunity

Type 1 diabetes (T1D) results from autoimmune destruction of β cells. Insufficient availability of biomarkers represents a significant gap in understanding the disease cause and progression. We conduct blinded, two-phase case-control plasma proteomics on the TEDDY study to identify biomarkers predictive of T1D development. Untargeted proteomics of 2,252 samples from 184 individuals identify 376 re

How do local peoples’ natural environments matter for peacebuilding and human rights? Nature beyond natural resources

In this popular science research-based article, I explore the multi-faceted roles of nature in fostering sustainable peace and human rights in Northern Uganda. I look into other roles that ‘nature’ might play beyond its conventional association with natural resources and biodiversity. In post-armed conflict settings, where addressing gross human rights violations and reconstructing the economy and

Sustainable Value Co-Creation in Welfare Service Ecosystems : Transforming temporary collaboration projects into permanent resource integration

The aim of this paper is to discuss the unexploited forces of user-orientation and shared responsibility to promote sustainable value co-creation during service innovation projects in welfare service ecosystems. The framework is based on the theoretical field of public service logic (PSL) and our thesis is that service innovation seriously requires a user-oriented approach, and that such an approa

The gold standard program (GSP) for smoking cessation : a cohort study of its effectiveness among smokers with and without cancer

BACKGROUND: Smoking cessation treatment is an important prognostic factor for survival after a cancer diagnosis, especially for tobacco-related cancers. After being diagnosed with lung cancer, approximately 50% of patients continue smoking or frequently relapse after a quit attempt. Given the importance of smoking cessation treatment for cancer survivors, the objective was to compare the effective

Diagnostic gastrointestinal markers in primary lung cancer and pulmonary metastases

Histopathological diagnosis of pulmonary tumors is essential for treatment decisions. The distinction between primary lung adenocarcinoma and pulmonary metastasis from the gastrointestinal (GI) tract may be difficult. Therefore, we compared the diagnostic value of several immunohistochemical markers in pulmonary tumors. Tissue microarrays from 629 resected primary lung cancers and 422 resected pul

Ways of Linking Drinking in the Roman Iron Age

My study of serving and drinking reveals that within ritual in the Roman Iron Age were inherently extensive non-ceremonial social practices, and many twisted facets of the public and private that we have learned to know from former studies. The variations in vessel composition in the drinking sets indicate a political-geographical distribution pattern for vessels of Roman origin. But, the drinking

The dosimetric effect of residual breath-hold motion in pencil beam scanned proton therapy – An experimental study

Background and purpose: Motion management in the treatment of lung cancer is necessary to assure highest quality of the delivered radiation therapy. In this study, the breath-hold technique is experimentally investigated for pencil beam scanned (PBS) proton therapy, with respect to the dosimetric effect of residual breath-hold motion. Material and methods: Three-dimensional (3D)-printed tumours ex