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Comorbidity in incident osteoarthritis cases and matched controls using electronic health record data

Background: Comorbidities are common in patients with osteoarthritis (OA). This study aimed to determine the association of a wide range of previously diagnosed comorbidities in adults with newly diagnosed OA compared with matched controls without OA. Methods: A case–control study was conducted. The data were derived from an electronic health record database that contains the medical records of pa

Mechanism of TNFα-induced downregulation of salt-inducible kinase 2 in adipocytes

Salt-inducible kinase 2 (SIK2) is highly expressed in white adipocytes, but downregulated in individuals with obesity and insulin resistance. These conditions are often associated with a low-grade inflammation in adipose tissue. We and others have previously shown that SIK2 is downregulated by tumor necrosis factor α (TNFα), however, involvement of other pro-inflammatory cytokines, or the mechanis

ROSSMARie: A Domain-Specific Language To Express Dynamic Safety Rules and Recovery Strategies for Autonomous Robots

Ensuring functional safety is a critical challenge for autonomous robots, as they must operate reliably and predictably despite uncertainty. However, existing safety measures can over-constrain the system, limiting the robot’s availability to perform its assigned task. To address this problem, we propose a more flexible strategy that equips robots with theability to adapt to system failures and re

Seasonal variations of intensity of avian malaria infection in the Thousand Island Lake System, China

Background: Migratory birds play an important part in the spread of parasites, with more or less impact on resident birds. Previous studies focus on the prevalence of parasites, but changes in infection intensity over time have rarely been studied. As infection intensity can be quantified by qPCR, we measured infection intensity during different seasons, which is important for our understanding of

SAFT Regimes and Laminar Burning Velocities : A Comparative Study of NH3+ N2+ O2and CH4+ N2+ O2Flames

Super adiabatic flame temperature (SAFT) is a distinctive phenomenon in the adiabatic flame where the local maximum temperature exceeds the adiabatic flame temperature. The flame temperatures exhibiting the extent of SAFT are difficult to measure with low uncertainties in experiments, while the laminar burning velocity also represents global flame features, thus could possibly be related to the SA

Elevated low-density lipoprotein cholesterol : An inverse marker of morbidity and mortality in patients with myocardial infarction

Background: The incidence of atherosclerotic cardiovascular disease increases with levels of low-density lipoprotein cholesterol (LDL-C). Yet, a paradox may exist where lower LDL-C levels at myocardial infarction (MI) are associated with poorer prognoses. Objective: To assess the association between LDL-C levels at MI with risk factor burden and cause-specific outcomes. Methods: Statin-naive patie

Exploration of a Web-based accessibility tool for public facilities

Purpose – This study aims to explore how an accessibility database (AD) has been developed and implemented as a tool for facility managers to evaluate and increase the accessibility of public facilities.Design/methodology/approach – Eight participants were strategically sampled for semi-structured interviews, and documents on the AD were gathered. The Consolidated Framework for Implementation ResePurpose – This study aims to explore how an accessibility database (AD) has been developed and implemented as a tool for facility managers to evaluate and increase the accessibility of public facilities.Design/methodology/approach – Eight participants were strategically sampled for semi-structured interviews, and documents on the AD were gathered. The Consolidated Framework for Implementation Rese

Visualizing Arc protein dynamics and localization in the mammalian brain using AAV-mediated in situ gene labeling

The activity-regulated cytoskeleton-associated (Arc) protein is essential for synaptic plasticity and memory formation. The Arc gene, which contains remnants of a structural GAG retrotransposon sequence, produces a protein that self-assembles into capsid-like structures harboring Arc mRNA. Arc capsids, released from neurons, have been proposed as a novel intercellular mechanism for mRNA transmissi

Radio Frequency InGaAs MOSFETs

III-V-based Indium gallium arsenide is a promising channel material for high-frequency applications due to its superior electron mobility property. In this thesis, InGaAs/InP heterostructure radio frequency MOSFETs are designed, fabricated, and characterized. Various spacer technologies, from high dielectric spacers to air spacers, are implemented to reduce parasitic capacitances, and fT/fmax are

University students’ Experiences of Occupational Balance in Response to the Environmental Changes Caused by the COVID-19 Pandemic

The COVID-19 pandemic caused universities worldwide, including those in Sweden, to adopt online distance learning as the primary teaching approach. However, there is limited research on how larger environmental changes affect university students’ occupational balance. In this study, 15 university students were interviewed, and their responses were analyzed using qualitative content analysis. The fThe COVID-19 pandemic caused universities worldwide, including those in Sweden, to adopt online distance learning as the primary teaching approach. However, there is limited research on how larger environmental changes affect university students’ occupational balance. In this study, 15 university students were interviewed, and their responses were analyzed using qualitative content analysis. The f

Development of the Swedish anticholinergic burden scale (Swe-ABS)

BackgroundDrugs with anticholinergic properties are associated with cognitive adverse effects, especially in patients vulnerable to central muscarinic antagonism. A variety of drugs show weak, moderate or strong anticholinergic effects. Therefore, the cumulative anticholinergic burden should be considered in patients with cognitive impairment. This study aimed to develop a Swedish Anticholinergic

Conspiracy Theories

Conspiracy theories are one way of dealing with gaps between hopes and reality, between the visible and the hidden, and between expert and lay knowledge. They are meaning systems that either explain or make sense of specific events or of social, political, or economic systems of power. Conspiracy theories assume that some actors intentionally conspire to harm others for their own benefit. Often th

Perpetual maintenance of machines with different urgency requirements

A garden is populated by n bamboos, each with its own daily growth rate. The Bamboo Garden Trimming Problem (BGT) is to design for a robotic gardener a perpetual schedule of cutting bamboos to keep the elevation of the garden as low as possible. The frequency of cutting is constraint by the time needed to move from one bamboo to the next, which is one day in Discrete BGT and is defined by the dist

Building Trust in the Classroom : A Conceptual Model for Teachers, Scholars, and Academic Developers in Higher Education

The quality of student-teacher classroom interactions is important to learning, belonging, and success, particularly for students from groups that have been historically excluded from or marginalized in higher education. The literature commonly asserts that one necessary part of high-quality educational interactions (whether in person or online) is trust, but several scholars note that trust has n