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Chemerin Is an Antimicrobial Agent in Human Epidermis

Chemerin, a chemoattractant ligand for chemokine-like receptor 1 (CMKLR1) is predicted to share similar tertiary structure with antibacterial cathelicidins. Recombinant chemerin has antimicrobial activity. Here we show that endogenous chemerin is abundant in human epidermis, and that inhibition of bacteria growth by exudates from organ cultures of primary human skin keratinocytes is largely chemer

Golfing with a murderer-Professional indifference and identity work in a Danish prison

Employees often use dis-identification strategies such as humor or cynicism to cope with emotional difficulties at work. In this paper, we show how dis-identification collapses among Danish correctional officers because of specific emotional contradictions arising from the 'dirty' aspects of their work. Correctional officers face the emotional dilemma of having to both get involved with the inmate

Studies of the pathogenesis of IgA nephropathy and Henoch-Schönlein purpura, with special reference to Streptococcus pyogenes infections and complement

Popular Abstract in Swedish IgA-nefropati (IgAN) är den vanligaste formen av primär inflammation av njurarna och Henoch-Schönlein purpura (HSP) den vanligaste formen av kärlinflammation i barndomen. HSP kan också drabba njurarna och kallas då Henoch-Schönlein nefropati (HSN). Orsaken till båda sjukdomar är inte helt klarlagd ännu. Båda kännetecknas av vävnadsinlagringar med immunoglobulin A (IgA)IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis and Henoch-Schönlein purpura (HSP) the most common form of vasculitis in childhood. HSP may affect kidneys, a complication termed Henoch-Schönlein nephropathy (HSN). Renal pathology in HSN resembles that seen in IgAN. The pathogenesis of IgAN and HSP is so far unclear. Both are characterized by tissue deposits of undergly

Isospin symmetry in the odd-odd mirror nuclei (44)V/(44)Sc

Excited states in the N = Z - 2 nucleus (44)V have been observed for the first time. The states have been identified through particle-gamma-gamma coincidence relationships and comparison with analog states in themirror nucleus (44)Sc. Mirror energy differences have been extracted and compared to state-of-the-art shell-model calculations which include charge-symmetry-breaking forces. Observed decay

A polynomial multicommodity flow problem with difficult path generation

In the paper we consider a commonly known network design problem with demand restoration assuming stub release. No compact linear programming (LP) formulation for the problem is known, and all known non-compact LP formulations of the problem require NP-hard path generation (pricing). Therefore, the problem itself is suspected to be NP-hard - this, however, is not actually known. The main result of

Förintelsens röda nejlika : Raoul Wallenberg som historiekulturell symbol

Förintelsens röfda nejlika behandlar framför allt Raoul Wallenbergs verkningshistoria, det vill säga hur han har diskuterats och representerats efter hans försvinnande 1945. En aspekt är det politiska och diplomatiska spelet kring honom, i Sverige, USA och Ungern. En annan är framställningen av honom i monument, på film och i tv-serier. Dessutom analyseras sambanden mellan det hemliga, diplomatisk

Infrastructures, lock-in, and sustainable urban development: the case of waste incineration in the Goteborg Metropolitan Area

This article explains how infrastructures with a sustainability record may evolve over time into a lock-in that slows the emergence of more sustainable urban infrastructures. A study of waste incineration in the Goteborg Metropolitan Area, Sweden, serves as an illustrative case. Taking leads from Unruh (2000, 2002), four rationales of lock-in are identified in the case: institutional, technical, c

Directional analysis of measured 60 GHz indoor radio channels using SAGE

Abstract in Undetermined Directional properties of the radio channel are of high importance for the development of reliable wireless systems operating in the 60 GHz frequency band. Using transfer functions measured from 61 to 65 GHz in a conference room we have extracted estimates of the multi-path component parameters using the SAGE algorithm. In the paper we compare results for line-of-sight (LO

A Highly Oriented Cubic Phase Formed by Lipids under Shear

We demonstrate the formation of a macroscopically oriented inverse bicontinuous cubic (QII) lipid phase from a sponge (L3) phase by controlled hydration during shear flow. The L3 phase was the monoolein/butanediol/water system; the addition of water reduces the butanediol concentration, inducing the formation of a diamond (QIID) cubic phase, which is oriented by the shear flow. The phenomenon was

Deregulation of protein phosphatase expression in acute myeloid leukemia

Acute myeloid leukemia (AML) is a highly malignant disease of myeloid cell line. AML is the most frequent adult leukemia with inadequate treatment possibility. The protein phosphatases are critical regulators of cell signaling, and deregulation of protein phosphatases always contribute to cell transformation. Although many studies established a relationship between protein phosphatases and leukemi

Lesion size affects diagnostic performance of IOTA logistic regression models, IOTA simple rules and risk of malignancy index in discriminating between benign and malignant adnexal masses

Objectives To estimate the ability to discriminate between benign and malignant adnexal masses of different size using: subjective assessment, two International Ovarian Tumor Analysis (IOTA) logistic regression models (LR1 and LR2), the IOTA simple rules and the risk of malignancy index (RMI). Methods We used a multicenter IOTA database of 2445 patients with at least one adnexal mass, i.e. the dat

Mast cell-associated alveolar inflammation in patients with atopic uncontrolled asthma

Background: A significant proportion of patients with asthma have persistent symptoms despite treatment with inhaled glucocorticosteroids. Objective: We hypothesized that in these patients, the alveolar parenchyma is subjected to mast cell-associated alterations. Methods: Bronchial and transbronchial biopsies from healthy controls (n = 8), patients with allergic rhinitis (n = 8), and patients with

Learning of Multi-Modal Stimuli in Hawkmoths

The hawkmoth, Manduca sexta, uses both colour and odour to find flowers when foraging for nectar. In the present study we investigated how vision and olfaction interact during learning. Manduca sexta were equally attracted to a scented blue coloured feeding target (multimodal stimulus) as to one that does not carry any scent (unimodal stimulus; visual) or to an invisible scented target (unimodal s

Space-, time- and spin-resolved photoemission

This article reviews photoemission experiments that simultaneously resolve at least two of the following degrees of freedom: space (real and momentum space), time (intrinsic time scale of a fast experiment or time-of-flight) and spin. In the spatiotemporal domain, imaging of fast processes by PEEM gives direct insight into plasmon dynamics or magnetization processes. In the category real space &am

Effects of uncertainties in experimental conditions on the estimation of adsorption model parameters in preparative chromatography

Model-based process design is increasingly popular when designing pharmaceutical purification processes. The effect of uncertainties in concentration measurements on the estimation of model parameters is analyzed for two cases of non-isocratic adsorption chromatography. A model, calibrated to experiments, is used to generate data by adding a Monte Carlo sampled error in the inlet concentrations. N