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Galectin-8 contains two different carbohydrate recognition domains (CRDs). Selective inhibitors for at least one CRD are desirable for galectin-8 biology studies and potentially for pharmacological purposes. Structure-guided design led to the discovery of potent and selective glycomimetic-heterocycle hybrid ligands, with a 4-(p-bromophenyl)phthalazinone derivative displaying a 34 μM Kd for galecti
Arkivens mediala villkor reglerar alltid historikerns förståelse och tolkning av det förflutna; det gäller även audiovisuella arkiv – vilka dessutom har en specifik mediehistoria. Denna bok handlar om hur audiovisuella medier kom att bevaras i Sverige under en sextioårsperiod med fokus på en rad olika modaliteter: film, ljud, eter. Det rör sig om en institutionshistorik med mediala förtecken där f
Firefighters are exposed to harmful and toxic substances during firefighting activities (i.e. training, live firefighting and overhaul) in building fires. This paper studies the impact of ‘new’ and sustainable materials (‘green’ buildings) on firefighter’s exposures during firefighting interventions. Cross-laminated wood (CLT), recycled wood material (referred to as ‘RECOMA’ in this paper) and gla
This paper examines the reaction-to-fire behaviour of building materials containing phase change materials by predicting their fire classification according to the European reaction-to-fire classification system (Euroclasses). While various building materials containing PCMs exist today, their application in buildings has been somewhat limited due to the fire behaviour of these building materials.
BACKGROUND: Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory joint disease, that influences patients' health in different ways, including physical, social, emotional, and psychological aspects. The goal of rheumatology care is to achieve optimal health and personalised care and therefore, it is essential to understand what health means for patients in the early course of RA. The aim
The aim of this study was to determine plasma levels of three adhesion molecules that may contribute to the development of diabetic retinopathy; soluble endothelial selectin (sE-selectin), soluble intercellular adhesion molecule-1 (sICAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1), in young adults, aged 15-34 years at diagnosis of diabetes, to find potential predictors for developm
Background: The aim of this study was to investigate the development of fatigue and mental illness between 3 and 12 months after critical COVID-19 and explore risk factors for long-lasting symptoms. Study Design and Methods: A prospective, multicenter COVID-19 study in southern Sweden, including adult patients (≥18 years) with rtPCR-confirmed COVID-19 requiring intensive care. Survivors were invi
We consider geometric problems on planar n2-point sets in the congested clique model. Initially, each node in the n-clique network holds a batch of n distinct points in the Euclidean plane given by Ο(log n)-bit coordinates. Ineach round, each node can send a distinct Ο(log n)-bit message to each other node in the clique and perform unlimited local computations. We show that the convex hull of the
Urban Lives emphasizes the importance of a micro-level approach in examining the lives of individuals and families in an industrial city, spanning over a century. The work deepens the understanding of major societal shifts and how they are intertwined with demographic behavior over the past 120 years. These societal transformations encompassed groundbreaking advancements in living standards, a rel
