The 68-kDa homodimeric 3C-like protease of SARS-CoV-2, Mpro (3CLpro/Nsp5), is a key antiviral drug target. NMR spectroscopy of this large system proved challenging and resonance assignments have remained incomplete. Here we present the near-complete (>97 %) backbone assignments of a C145A variant of Mpro (MproC145A) both with, and without, the N-terminal auto-cleavage substrate sequence, in its na

This chapter introduces the project of this volume, laying out the coordinates of the phenomena and the questions addressed in the book. After reviewing the enduring significance of territories in the current historical context, we situate the science of territories in terms of its theoretical foundations and continuing dialogue with other threads in the social sciences. We then present to the rea

The support from SSM has made it possible to continue collecting brown algaefrom the place on the Swedish west coast where regular collections began asearly as 1967. The support has also enabled more extensive analyses ofpreviously collected material than was possible before. This applies to bothsupplementary analyses of previously reported radionuclides and analysis ofnew ones. The project has al

Diverse bilingual experiences have implications for language comprehension, including pragmatic elements such as verbal irony. Irony comprehension is shaped by an interplay of linguistic, cognitive, and social factors, including individual differences in bilingual experience. We examined the relationship between individual differences related to bilingualism, specifically, the capacity to understa

OBJECTIVE: Few studies address results from use of new technology and patient participation in hypertension management. The PERHIT Study is a multicentre randomised controlled trial with the aim to evaluate the effects of a person-centred approach using a web-based, interactive self-management system through the patient´s own mobile phone on blood-pressure and well-being. Primary aim is the degree

The salinization of freshwaters is a global threat to aquatic biodiversity. We quantified variation in chloride (Cl−) tolerance of 19 freshwater zooplankton species in four countries to answer three questions: (1) How much variation in Cl− tolerance is present among populations? (2) What factors predict intraspecific variation in Cl− tolerance? (3) Must we account for intraspecific variation to ac

Multiple guidelines exist for the diagnosis and management of mitral regurgitation (MR), the second most common valvular heart disease in high-income countries, with recommendations that do not always match. We systematically reviewed guidelines on diagnosis and management of MR, highlighting similarities and differences to guide clinical decision-making. We searched national and international gui

BACKGROUND: Data on interventions to reduce postoperative pancreatic fistula (POPF) following pancreatoduodenectomy (PD) are conflicting. The aim of this study was to assimilate data from RCTs. METHODS: MEDLINE and Embase databases were searched systematically for RCTs evaluating interventions to reduce all grades of POPF or clinically relevant (CR) POPF after PD. Meta-analysis was undertaken for

OBJECTIVE: This study aimed at exploring the perspectives and experiences of individuals with neck pain by synthesizing all available qualitative studies. METHODS: A systematic, qualitative meta-summary and meta-synthesis was conducted following the 5-step methodology proposed by Sandelowski and Barroso. A systematic search of 9 electronic databases was conducted in May 2021. Methodological qualit

Background: Survivors of childhood acute lymphoblastic leukemia (ALL) may be at increased long-term risk of hospitalization for somatic diseases. However, large population-based cohort studies with risk estimates for survivors successfully cured without experiencing a relapse or requiring hematopoietic stem cell transplantation (HSCT) are lacking. Methods: Danish and Swedish patients diagnosed wit

CONTEXT: Minipuberty, a period of a transient activation of the hypothalamic-pituitary-gonadal (HPG) axis in both sexes, enables evaluation of gonadal function in infants suspected of hypogonadism. However, female minipuberty remains poorly elucidated. OBJECTIVE: We aimed to establish continuous reference ranges for the most commonly used reproductive hormones and to evaluate the dynamics of the H

The heart rate during atrial fibrillation (AF) is highly dependent on the conduction properties of the atrioventricular (AV) node. These properties can be affected using β-blockers or calcium channel blockers, mainly chosen empirically. Characterization of individual AV-nodal conduction could assist in personalized treatment selection during AF. Individual AV nodal refractory periods and conductio

This work investigates dovetail joints as a means to mount pre-wound coils in an electrically excited rotor for a synchronous machine for EV application. The aim is to manufacture a prototype of a direct cooled machine with hollow rectangular rotor windings which requires a rotor design where the windings can be applied on the poles separately. Two experimental tensile tests are made to validate t

This history of wind energy in Denmark describes how top-down policy support and bottom-up initiatives shaped the Danish wind power sector, ultimately facilitating the integration of wind energy in the grid. From the early days of wind power, innovative entrepreneurs tinkered with and improved upon the emergent wind power technologies, but coal and oil remained the prioritized fuels for the almost

The small scandinavian country of Denmark is ranked among the top countries in the world according to the World Energy Council (WEC) energy trilemma criteria: energy security, energy equity, and sustainability.

The majority of local respondents in a large-scale survey were in favour of planned local wind farms on the Danish coast, despite these wind farm plans being the source of wider public and political contestation and opposition. Here we discuss results from the open-ended questions in the survey, specifically focusing on comments expressing how some respondents felt split in their views of these wi

Most cross-cultural studies on management control have compared Anglo-Saxon firms to Asian firms, leaving us with limited understanding of potential variations between developed Western societies. This study addresses differences and similarities in a wide variety of management control practices in Anglo-Saxon (Australia, English Canada), Germanic (Austria, non-Walloon Belgium, Germany) and Nordic