Timing and indication for pulmonary valve replacement (PVR) in patients with repaired Tetralogy of Fallot (rToF) and pulmonary regurgitation (PR) are uncertain. To improve understanding of pumping mechanics, we investigated atrioventricular coupling before and after surgical PVR. Cardiovascular magnetic resonance (CMR) were performed in patients (n=12) with rToF and PR>35% before and after PVR and

We evaluated the performance of CSF biomarkers for predicting risk of clinical decline and conversion to dementia in non-demented patients with cognitive symptoms. CSF samples from patients in two multicentre longitudinal studies (ADNI, n = 619; BioFINDER, n = 431) were analysed. Aβ(1–42), tTau and pTau CSF concentrations were measured using Elecsys CSF immunoassays, and tTau/Aβ(1–42) and pTau/Aβ(

Humans learn new concepts extremely fast. One or two examples of a new concept are often sufficient for us to grasp its meaning. Traditional theories of concept formation, such as symbolic or connectionist representations, have problems explaining the quick learning exhibited by humans. In contrast to these representations, I advocate a third form of representing categories, which employs geometri

Innovation productivity of expatriate researchers and human capital that empowers them is an important issue; however, with a scarcity of relevant data, formal empirical evidence has been limited. This paper uses a rich dataset of foreign researchers at a leading German research institution to study the drivers of their innovation productivity (measured by patents and invention disclosures). Anoth

AIMS: Remodelling of the extracellular matrix (ECM) is a key mechanism involved in the development and progression of heart failure (HF) but also functional in associated pulmonary hypertension (PH). Our aim was to identify plasma ECM proteins associated to end-stage HF and secondary PH in relation to haemodynamics, before and after heart transplantation (HT).METHODS AND RESULTS: Twenty ECM plasma

Pervaporation offers solutions for a wide range of applications ranging from the dehydration of organic compounds to the recovery of organic compounds from water and the separation of organic mixtures. While the combination of pervaporation and distillation in a hybrid process to break azeotropes is well established on an industrial scale, successful applications of hydrophobic pervaporation are r

The higher-level systematics of featherwing beetles (Coleoptera: Ptiliidae), the smallest non-parasitic insects and abundant in the world's forests, is poorly known. Based on larval morphology, the systematic relationships and internal classification are revised and analysed from a comparative, evolutionary and phylogenetic perspective. We introduce 37 morphological characters of all instars and o

Global Health has not featured as prominently in the European Union (EU) research agenda in recent years as it did in the first decade of the new millennium, and participation of low-income and middle-income countries (LMICs) in EU health research has declined substantially. The Horizon Europe Research and Innovation Framework adopted by the European Parliament in April 2019 for the period 2021-20

Human land use threatens global biodiversity and compromises multiple ecosystem functions critical to food production. Whether crop yield-related ecosystem services can be maintained by a few dominant species or rely on high richness remains unclear. Using a global database from 89 studies (with 1475 locations), we partition the relative importance of species richness, abundance, and dominance for

This paper examines the Swedish experience of forward guidance 2007-2018. We focus on three interrelated issues: first, the effects of forward guidance on the discussion within the Board of Directors of the Riksbank, second, on the communication between the Riksbank and the public, and third, on the interest rate expectations held by various groups in Swedish society. We conclude that forward guid

Transcription factor (TF)-based reprogramming of somatic tissues holds great promise for regenerative medicine. Previously, we demonstrated that the TFs GATA2, GFI1B, and FOS convert mouse and human fibroblasts to hemogenic endothelial-like precursors that generate hematopoietic stem progenitor (HSPC)-like cells over time. This conversion is lacking in robustness both in yield and biological funct