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Out of Control Because of Harmonics - An Analysis of Harmonic Response of an Inverter Train

Presents a method to use linear analysis to capture the frequency coupling of nonlinear and time-varying components. System stability is analyzed by connecting the harmonic transfer functions of the different component models. This facilitates an object-oriented approach to modeling, which supports reuse of models. An analysis of the complete railway system is, of course, difficult. Several locomo

A selective tumor microvasculature thrombogen that targets a novel receptor complex in the tumor angiogenic microenvironment

We have previously shown that part of the heparin-binding domain of the vascular endothelial growth factor (VEGF), designated HBDt, localizes very selectively to surfaces of the endothelial cells of U blood vessels. Here, we have coupled the HBDt to the extracellular domain of tissue factor (TFt), to locally initiate the thrombogenic cascade. In tumor-bearing mice, infusion of this HBDt.TFt result

Long-term neuroretinal full-thickness transplants in a large animal model of severe retinitis pigmentosa.

The purpose of this study was to explore neuroretinal transplantation in a large animal model of severe retinitis pigmentosa and to establish graft development, long-term survival, graft-host integration, and effects on the host retina. Methods Rhodopsin transgenic pigs, aged 6 months, received in one eye a fetal full-thickness neuroretinal sheet in the subretinal space by means of vitrectomy and

Compaction and decompaction of DNA in the presence of catanionic amphiphile mixtures

The dissociation of DNA-cationic surfactant complexes with the addition of a negative amphiphile was studied by fluorescence microscopy (FM). The unfolding of DNA molecules previously compacted with cationic surfactant was shown to be dependent on the anionic surfactant chain length; lower amounts of a longer-chain surfactant were needed to release DNA into solution. However, we observed no depend

Non-coding antisense transcription detected by conventional and single-stranded cDNA microarray

Background: Recent studies revealed that many mammalian protein- coding genes also transcribe their complementary strands. This phenomenon raises questions regarding the validity of data obtained from double-stranded cDNA microarrays since hybridization to both strands may occur. Here, we wanted to analyze experimentally the incidence of antisense transcription in human cells and to estimate their

Sites and the mental landscape : Stone Age in the Kullen district, North-western Scania, Sweden

Abstract in Undetermined The approach of the mental landscape enlarges the perspectives for interpreting sites and settle- ments. In the Kullen district sites and settlements is theorized by breaking down the dichotomi- es of Mesolithic and Neolithic and the archaeologically constructed borderline between the periods. The terminology and the interpretation of site and settlement need to be extende

Supermacroporous cryogel matrix for integrated protein isolation - Immobilized metal affinity chromatographic purification of urokinase from cell culture broth of a human kidney cell line

A new type of supermacroporous, monolithic, cryogel affinity adsorbent was developed, allowing the specific capture of urokinase from conditioned media of human fibrosarcoma cell line HT1080. The affinity adsorbent was designed with the objective of using it as a capture column in an integrated perfusion/protein separation bioreactor setup. A comparative study between the utility of this novel cry

Upregulated TRPC1 Channel in Vascular Injury In Vivo and Its Role in Human Neointimal Hyperplasia.

Occlusive vascular disease is a widespread abnormality leading to lethal or debilitating outcomes such as myocardial infarction and stroke. It is part of atherosclerosis and is evoked by clinical procedures including angioplasty and grafting of saphenous vein in bypass surgery. A causative factor is the switch in smooth muscle cells to an invasive and proliferative mode, leading to neointimal hype

Giorgio Agamben and the spatialities of the camp: An introduction

The Italian political philosopher Giorgio Agamben's conclusion that the camp has replaced the city as the biopolitical paradigm of the West is as difficult to digest as it is easy to see how it responds to contemporary political tendencies in the world today. In this introduction to this theme issue on Giorgio Agamben and the spatialities of the camp, a detailed exposition emulating the structure

Study of restriction fragment length polymorphism in the cystatin C gene of elderly patients with dementia and aged Down's syndrome patients

Using a full length cystatin C cDNA probe and the Alu I restriction enzyme a total of 33 patients with senile dementia, Alzheimer type and 31 Down's syndrome patients have been investigated for the presence of the 630 bp Alu I restriction fragment length polymorphism in the cystatin C gene detected in Icelandic patients with hereditary cystatin C amyloid angiopathy. Results showed that all the pat