Type 2 diabetes (T2D) is caused by insufficient insulin secretion from pancreatic β-cells. To identify candidates contributing to T2D pathophysiology, we studied human pancreatic islets from ~300 individuals. We found 395 differentially expressed genes (DEGs) in islets from individuals with T2D, including, to our knowledge, novel (OPRD1, PAX5, TET1) and previously identified (CHL1, GLRA1, IAPP) ca

Aim: The aim of the study was to explore the assessment fidelity of Språkfyran, a language screening instrument for four-year-old children. Språkfyran is a mandatory part of the healthcare program within the Swedish Child Health Service (CHS) and is offered to all four-year-olds in the region Scania in Sweden. Methods: The study was based on structured observations of twenty-four specialist CHS nu

Paleoklimatologi – läran om hur klimatet utvecklats genom jordens historia – ger oss referensramar för att sätta dagens klimat och möjliga framtida klimatförändringar i ett historiskt perspektiv. Till exempel visar nya analyser av historiska klimatarkiv att för norra halvklotet var perioden 1983-2012 sannolikt den varmaste på 1400 år. Vi ser även att vid den senaste värmeperioden, för 125 000 år s

Accidentally introduced parasitoids can provide biological control of the invasive pest they followed but could also pose a threat to native species if they are not specialists. Attack of native species could reduce the effectiveness of adventive natural enemies if it is accompanied by reduced fitness, and it may increase acceptance of non-target species. We tested how intermittent host shift and

Background: The Nordic Nutrition Recommendations (NNR) are developed to promote public health and to prevent food-related diseases such as obesity and cardiovascular diseases. Objective: To investigate the nutrient intake and adherence to the NNR in a Swedish cohort with abdominal obesity. Design: Dietary intake data were collected using 3-day food diaries and anthropometry and clinical chemistry

High-order harmonic generation (HHG) in gases leads to short-pulse extreme ultraviolet (XUV) radiation that is useful in a number of applications, such as attosecond science and nanoscale imaging. However, this process depends on many parameters, and there is still no consensus on how to choose the target geometry to optimize the source efficiency. We review the physics of HHG with emphasis on the

Introduction: Understanding symptom patterns in atrial fibrillation (AF) can help in disease management. We report on the application of natural language processing (NLP) to electronic medical records (EMRs) to capture symptom reports in patients with newly diagnosed (incident) AF. Methods and Results: This observational retrospective study included adult patients with an index diagnosis of incide

Dyspnea is a common and highly distressing symptom in patients with advanced illnesses. Many patients continue to experience chronic dyspnea despite optimal management of underlying disease(s) and various non-pharmacologic interventions, necessitating the consideration of pharmacologic therapies for palliation of dyspnea. One commonly asked question by clinicians is whether benzodiazepines have a

Direct oral anticoagulants (DOACs) require perioperative vigilance to reduce the risk of spinal haematoma. There is a little of information concerning which plasma concentrations of DOACs are safe when administering central neuraxial blocks (CNBs) and there is a wide variability in the rate of elimination, both between individuals and DOACs.

Bookkeeping and accounting is a prevalent feature of small organizations, which has changed face quite substantially with the advent of personal computers and, later, the Internet. The emergence of digitalized accounting procedures has taken place in a nexus of different types of actors (e.g., software developers, accountancy firms and the businesses themselves), regulatory frameworks (e.g., bookk

Mycket har sagts och skrivits om polarisering men sällan med några historiska tillbakablickar. Ibland kan det nästan framstå som att polarisering är ett helt nytt fenomen.I den här boken vänder åtta idéhistoriker på perspektivet och argumenterar för att företeelsen är lätt att finna även i det förgångna. Skribenterna ger oss inblickar i polariserade situationer och konflikter som

Crises are a major driving force behind cooperation in the European Union. During severe crises, cooperation has been enlarged and intensified. The Ukrainian war and the covid-19 pandemic are two examples of this pattern, not least when it comes to the conduct of stabilization policies in the EU. In this chapter, we discuss the implications for the EU of a move towards increased fiscal federalism.

With the urgent demand for ultralow-temperature refrigerators worldwide, the operation reliability and stability of the refrigeration system becomes greatly crucial. In this study, a -80 oC ultralow-temperature cascade refrigeration system (CRS) is developed. From aspects of global warming potential (GWP) and ozone depletion potential (ODP), the environmentally friendly refrigerants R290 and R170

Top predators can affect the behaviour of prey species via lethal (direct kill) or non-lethal effects (i.e., through predation risk). For example, prey species may move from areas perceived as risky to safer spaces where predation risk is lower, which can have important consequences for investment in foraging, movement, and mating, and for the behaviour and habitat use of other species, such as me

Analys av HD:s beslut i mål Ö 1246-22 ("Ringen")