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The onset of deglaciation of Cumberland Bay and Stromness Bay, South Georgia
Carbon dating of basal peat deposits in Cumberland Bay and Stromness Bay and sediments from a lake in Stromness Bay, South Georgia indicates deglaciation at the very beginning of the Holocene before c. 9500 C-14 yr BP. This post-dates the deglaciation of one local lake which has been ice-free since at least 15 700 C-14 yr BP on account of its atypical geomorphological location. The latter indicate
Congenital and acquired activated protein C resistance.
Resistance to the anticoagulant action of activated protein C, APC resistance, is a highly prevalent risk factor for venous thrombosis among individuals of Caucasian origin. In most cases, APC resistance is associated with a single missense mutation in the gene for coagulation factor V (FVLeiden), which predicts the replacement of Arg506 with a Gln at one of the cleavage sites for APC in factor V.
Analyzing tumor gene expression profiles
A brief introduction to high throughput technologies for measuring and analyzing gene expression is given. Various supervised and unsupervised data mining methods for analyzing the produced high-dimensional data are discussed. The main emphasis is on supervised machine learning methods for classification and prediction of tumor gene expression profiles. Furthermore, methods to rank the genes accor
New ISSCR Guidelines Underscore Major Principles for Responsible Translational Stem Cell Research
Insulin release and islet nitric oxide synthase (NOS) activities in type 2 diabetes obese model, the ob/ob mouse. Interection with regulatory peptides and islet carbon monoxide (CO) production
The Environmental Implications of Electronic Commerce - A Critical Review and Framework for Future Investigation
There are accelerating trends for the implementation of electronic commerce(e-commerce) as an extra marketing channel for selling products globally via the access of the Internet. This is expected to in¯uence the shape of future cities and the conservation of natural resources. This paper critically reviews the current research work to date regarding the environmental implications of e-commerce. T
Comparison of strand displacement and ligase chain amplification for detection of Chlamydia trachomatis infection in urogenital specimens.
The influence of dietary fibre source and gender on the postprandial glucose and lipid response in healthy subjects.
BACKGROUND: Consumption of soluble dietary fibre is correlated with decreased postprandial glucose and insulin responses and hence has beneficial effects on the metabolic syndrome. AIM OF THE STUDY: To investigate the effects on postprandial glucose, insulin and triglyceride concentrations of meals enriched with soluble dietary fibres from oats, rye bran, sugar beet fibre or a mixture of these thr
A two-equation turbulence model and its application to a buoyant diffusion flame
A modified k–ε two-equation turbulence model was developed to improve the consideration of the important buoyancy effect on turbulence and turbulent transport, which is a serious deficiency of the standard buoyancy-modified k–ε model. The present model was tested against both plane and axisymmetric thermal plumes and a buoyant diffusion flame. The model was found to be stable, computationally econ
A young afforestation area in Iceland was a moderate sink to CO2 only a decade after scarification and establishment
This study reports on three years (2004-2006) of measurements of net ecosystem exchange (NEE) over a young Siberian larch plantation in Iceland established on previously grazed heathland pasture that had been scarified prior to planting. The study evaluated the variation of NEE and its component fluxes, gross primary production (GPP) and ecosystem respiration (R-e), with the aim to clarify how cli
Soluble pilin of Neisseria gonorrhoeae interacts with human target cells and tissue
Pili of Neisseria gonorrhoeae are phase-variable surface structures that mediate adherence to host target cells. Each pilus is composed of thousands of major pilus subunits, pilins, pilus-associated protein PilC, and possibly other components. Piliated and nonpiliated gonococcal clones may secrete a soluble smaller pilin (S-pilin) that is cleaved after amino acid 39 of the mature pilin protein. He
Effects of repeated exposure to 4 ppm nitrogen dioxide on bronchoalveolar lymphocyte subsets and macrophages in healthy men
Following the basal descriptive studies of the bronchoalveolar inflammatory cell response induced by single exposure with nitrogen dioxide (NO2) in man, it was considered important to clarify the cell response to repeated exposure with NO2. This investigation was, therefore, undertaken with bronchoalveolar lavage (BAL) 3 weeks before and 24 h after six repeated exposures with 4 ppm NO2 (7 mg.m-3)
Serotonin neuron-dependent and -independent reduction of dyskinesia by 5-HT(1A) and 5-HT(1B) receptor agonists in the rat Parkinson model.
5-HT(1) receptor agonists have been shown to reduce abnormal involuntary movements (AIMs) in the rat and monkey models of l-DOPA-induced dyskinesia. Different mechanisms have been proposed to underlie this effect. Activation of pre-synaptic 5-HT(1) receptors has been suggested to inhibit dysregulated release of dopamine from the serotonin terminals, and thus, abnormal activation of striatal dopami
Is removal of subchondral bone plate advantageous in cemented cup fixation? A randomized RSA study.
There is uncertainty regarding whether and how the subchondral bone plate should be treated during acetabular preparation for cemented cup fixation in a total hip arthroplasty. We hypothesized that removing the bone plate would improve the cement-bone interface without jeopardizing the initial cup stability, and therefore, be advantageous to long-term cup survival. We randomized 50 patients with p
Newborn infants can organize the auditory world.
Monte Carlo simulation of the mean force between two like-charged macroions with simple 1 : 3 salt added
The mean force and the potential of the mean force between two like- harged macroions with monovalent counterions and added simple 1:3 salt described within the primitive model and confined in a cylindrical cell have been investigated by Monte Carlo simulations. Without additional salt, a strongly repulsive mean force was obtained at all macroion separations, consistent with a stable solution of m
Videofluoroscopy in elderly patients with aspiration: importance of evaluating both oral and pharyngeal stages of deglutition
Oropharyngeal functional impairment increases with age so that radiologists frequently are asked to determine the cause of aspiration in elderly patients. Neuromuscular and cognitive impairment often make it difficult to perform and interpret videofluoroscopic deglutition examinations in these patients. We retrospectively reviewed the barium swallow examinations in 50 elderly patients (mean age, 8
Is the life expectancy of anesthesiologists decreased?
Performance analysis and modelling of an OSA gateway
It is foreseen that you in the future should be able to use the same services independent of where you are positioned or which terminal that is used. The open service architectures provide these opportunities. Open Service Access (OSA) is an example of such an architecture and it is part of the specification delivered by 3GPP. This paper explains the OSA architecture and presents a model of an OSA
