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Multiple endocrine neoplasia type 1 polymorphism D418D is associated with sporadic primary hyperparathyroidism

BACKGROUND: Sporadic primary hyperparathyroidism (pHPT) occurs separately and in several hereditary disorders including multiple endocrine neoplasia type 1. Irradiation to the neck, female gender, and age are well-identified risk factors that predispose to pHPT. The multiple endocrine neoplasia type 1 gene is the most commonly deranged gene in parathyroid adenomas and contains several polymorphism

Underexpression of Gcm2, a master regulatory gene of parathyroid gland development, in adenomas of primary hyperparathyroidism

OBJECTIVE: Glial cells missing (Gcm) was first identified as a binary switch between neuronal and glial determination in Drosophila. Two homologues of Drosophila Gcm have been identified in mice and humans, namely Gcm1 and Gcm2. Mouse Gcm2 is restricted to parathyroid tissues and Gcm2 was recently identified as a master regulatory gene of parathyroid gland development as Gcm2 knockout mice lack pa

Intragenic allelic loss and promoter hypermethylation of the RIZ1 tumor suppressor gene in parathyroid tumors and pheochromocytomas

BACKGROUND: Loss of heterozygosity (LOH) at chromosome 1p is a common abnormality in both parathyroid tumors and pheochromocytomas. The recently characterized tumor suppressor gene RIZ1, located at 1p36, has emerged as a putative candidate to be involved in endocrine tumorigenesis.MATERIAL: Presence of allelic loss, promoter hypermethylation, and mutational aberrations of the RIZ1 gene were invest

A versatile organisation : Mapping the military's core roles in a changing security environment

What roles are military institutions expected to play in today's rapidly changing security environment? How are they supposed to interact with the society they are tasked to protect? These questions have been posed by classical military sociologists as well as by a newer generation of scholars. Yet so far, a comprehensive mapping of the military's potential roles in contemporary society is missing

A side-channel attack on a masked IND-CCA secure saber KEM implementation

In this paper, we present a side-channel attack on a first-order masked implementation of IND-CCA secure Saber KEM. We show how to recover both the session key and the long-term secret key from 24 traces using a deep neural network created at the profiling stage. The proposed message recovery approach learns a higher-order model directly, without explicitly extracting random masks at each executio

25-hydroxyvitamin D(3)-1alpha-hydroxylase expression in normal and pathological parathyroid glands

Active vitamin D, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], plays a pivotal role in calcium homeostasis and bone metabolism. Circulating levels of 1,25(OH)(2)D(3) are thought to be dependent mainly on the activity of the renal cytochrome P450 enzyme 25-hydroxyvitamin D(3)-1alpha-hydroxylase (1alpha-hydroxylase), which is potently induced by PTH. However, 1alpha-hydroxylase activity or expressi

Allelic loss in clinically and screening-detected primary hyperparathyroidism

OBJECTIVE: Parathyroid adenomas frequently harbour deletions of genomic DNA at chromosome regions 1p, 6q and 11q. In this study we related clinical characteristics in 56 patients with primary hyperparathyroidism (pHPT) to loss of heterozygosity (LOH) in these chromosome regions.DESIGN: LOH analysis was performed on 56 sporadic parathyroid tumours using a total of 18 microsatellite markers for chro

c-Abl kinase regulates neutrophil extracellular trap formation and lung injury in abdominal sepsis

Sepsis is associated with exaggerated neutrophil responses although mechanisms remain elusive. The aim of this study was to investigate the role of c-Abelson (c-Abl) kinase in neutrophil extracellular trap (NET) formation and inflammation in septic lung injury. Abdominal sepsis was induced by cecal ligation and puncture (CLP). NETs were detected by electron microscopy in the lung and by confocal m

Health-Care and Societal Costs Associated with Non-Persistence with Subcutaneous TNF-α Inhibitors in the Treatment of Inflammatory Arthritis (IA) : A Retrospective Observational Study

Objective: A few studies have suggested that patients with inflammatory arthritis (IA) who remain persistent with subcutaneous TNF-α inhibitors (SC-TNFi) incur lower health care costs than patients who discontinue treatment, whereas data on the impact of non-persistence on indirect costs are largely lacking. Furthermore, existing estimates are based on fixed follow-ups, in relation to treatment in

High PGD2 receptor 2 levels are associated with poor prognosis in colorectal cancer patients and induce VEGF expression in colon cancer cells and migration in a zebrafish xenograft model

Background: Despite intense research, the prognosis for patients with advanced colorectal cancer (CRC) remains poor. The prostaglandin D2 receptors DP1 and DP2 are explored here as potential therapeutic targets for advanced CRC. Methods: A CRC cohort was analysed to determine whether DP1 and DP2 receptor expression correlates with patient survival. Four colon cancer cell lines and a zebrafish meta

Videoessäer som pedagogisk metod för att utveckla medie- och informationskunnighet

Denna reflektion handlar om hur videoessän, som ett alternativ till mer traditionella examinationsformer, kan bidra till att utveckla studenters medie- och informationskunnighet. Videoessäns funktion i film- och medievetenskaplig utbildning presenteras. Därefter diskuteras det pedagogiska upplägget för kursen där videoessän ingick som examinationsmoment. En slutsats är att videoessän är en examina

Ut ur pandemin – rakt in i den digitala transformationen. Ska stadskärnans överlevnad bli en valfråga 2022?

Coronapandemin i kombination med ökad e-handel har varit ännu ett svårt slag mot svenska stadskärnor. Under 2020 och 2021 har flera stora butikskedjor valt att lämna stadskärnorna till förmån för externa handelsplatser och onlinehandel. Larmrapporterna och lösningar på problemet har varit många under 2021. Denna rapport är en analys och utvärdering av vad som sagts i media, tidigare forskning och

Hovrättens möbler och andra betydelsefulla saker

På Hovrätten över Skåne och Blekinge finns flera möbler och föremål som funnits och använts sedan 1800-talet. Vi lät docenterna Martin Sunnqvist och Linda Fagerström ta en titt på några saker som de tycker är intressanta att berätta mer om.Filmen är en del av hovrättens 200-årsjubileum som firas från maj 2021 till maj 2022. Mer information finns på hovrättens webbplats: www.domstol.se/jubileumsare

A scoping review of public building accessibility

Background: The built environment needs to be designed so that all people can participate in the activities they want and need to do. Yet, accessibility is difficult to put into practice, and accessibility issues tend to be overlooked in the building and planning processes. Objectives: The aim of this scoping review was to summarize the research front in the area of accessibility to public buildin

Diversity, lnclusion, Equity and the Threat to Academic Freedom

There can be no doubt that discrimination based on sex, race, ethnicity, religion or beliefs should not be tolerated in academia. Surprisingly, however, in recent years, policies of Diversity, Inclusion and Equity (DIE), officially introduced to counteract discrimination, have increasingly led to quite the opposite result: the exclusion of individuals who do not share a radical ‘woke’ ideology on