A strategy for generating potential galectin inhibitors was devised based on derivatization at the C-3′ atom in 3′-amino-N-acetyllactosamine by using structural knowledge of the galectin carbohydrate recognition site. A collection of 12 compounds was prepared by N-acylations or N-sulfonylations. Hydrophobic tagging of the O-3 atom in the N-acetylglucosamine residue with a stearic ester allowed rap

We develop a new elementary move for simulations of polymer chains in torsion angle space. The method is flexible and easy to implement. Tentative updates are drawn from a (conformation-dependent) Gaussian distribution that favors approximately local deformations of the chain. The degree of bias is controlled by a parameter b. The method is tested on a reduced model protein with 54 amino acids and

Pilosella floribunda (Wimm. and Grab.) Arv-Touv. is reported as new to the provinces Skane and Smaland, southernmost Sweden. There is one recent finding in each of these provinces, in both cases as an established alien on roadsides. Hieracium nemorivagum Jord. ex Boreau, has recently been found at several sites in eastern Skane and at one site in each of the provinces Blekinge and Smaland. This sp

The complexation of sulfate ions at the goethite-water interface has been studied by equilibrium measurements at 298.2 +/- 0.5 K and by infrared spectroscopy. A unified set of data from potentiometric titrations and batch adsorption experiments were evaluated according to an extended Constant Capacitance Model. The obtained equilibrium model consists of two outer-sphere complexes: = FeOH2+, SO42-

Detrital zircon U-Pb SIMS data on quartz-rich metasandstone units presumed to belong to the upper part of the Svecofennian stratigraphy in southeastern Finland and east-central Sweden suggest the existence of clastic sedimentary basins between the two main orogenic phases at 1.89-1.86 Ga and 1.83-1.79 Ga, during a period referred to as the intra-orogenic phase (1.86-1.83 Ga). Stratigraphically bel

Sensitization of guinea pigs by intradermal injections of the occupational allergen trimellitic anhydride (TMA) in oily vehicle has been shown to be very reproducible. We studied the effect of intradermal sensitization with ovalbumin (OA) in oily vehicle on immune and airway responses in guinea pigs. We also compared airway responses to trimellitic anhydride or Dermatophagoides farinae (DF; mite)

We present quantum path distributions of high-order harmonics produced by rare gas atoms interacting with an intense 810 nm laser field, obtained by numerical integration of the time-dependent Schrodinger equation within the single active electron approximation. We find that the distributions are sensitive to the atomic potentials, and differ from the distributions predicted by the strong field ap

The impact of cytogenetic characterization based on chromosome banding analyses and fluorescence in situ hybridization on clinical decision making has increased dramatically during recent years. Therefore, laboratory techniques have to be optimized to provide reliable results for optimal patient care. In addition, quick and correct results save time and money by preventing unnecessary additional d

A novel method to use multimode diode lasers for gas detection is demonstrated. The relationship between the intensity decay of partially absorbed multiple modes and the target gas concentration is presented. The gas concentration is retrieved by a linear-regression-based procedure applied on simultaneously recorded absorption signals in a dual-beam wavelength-modulation configuration. Signals of

Objective To compare the time taken to establish a clinical diagnosis of Frontotemporal dementia (FTD) relative to a diagnosis of early onset Alzheimer's dementia (AD). Methods The data came from 89 patients under the age of 65 years, 52 of whom met the Manchester-Lund criteria for Frontotemporal dementia; 20 of these came from Lund University Hospital in Sweden. The other 32 patients with FTD alo

BACKGROUND: Total heart volume variation (THVV) and center of volume variation (COVV) likely affects the efficiency of cardiac pumping, but no study has determined COVV of the heart throughout the cardiac cycle or the effect of surgery on THVV in adults. Therefore, the purposes of this study were to determine COVV in healthy adults and patients with cardiac failure due to ischemic heart disease (I

The three basic paradigms of behaviour science, association, structure, and process, were used to anchor the simulation of new forms of social organization. These have been projected by means of a behaviour, a humanist, and a growth model. The Swedish model was also included as a possible point of reference. This article summarizes the results of two experiments, one on the assessment of quality o

Activity and stability characteristics of an alkaline active cyclodextrin glycosyltransferase (CGTase) enzyme from the alkaliphilic Bacillus agaradhaerens LS-3C strain are reported. The enzyme displays unusually high amylolytic activity in relation to the cyclization activity. Disproportionation activity of the CGTase was optimal with maltose as the acceptor substrate. The product of cyclization r

1. Climbing fibres were activated by peripheral nerve stimulation at 'high' frequencies (greater than 3 Hz) for 15-25 s and then at 0.9 Hz for about 1 min. The high frequency activation induced a post-conditioning inhibition, lasting up to about 1 min, of climbing fibre responses recorded from the cerebellar surface. 2. Electrolytic lesions were made in the superior cerebellar peduncle (brachium c

An update of the B physics performance of the ATLAS experiment is presented. After a short review of B production and decays at LHC, the main features of the ATLAS detector are described, and the present construction status is shown. Physics topics which are presented are: precision measurements, rare decays, and B production. It is shown that despite of recent changes in the trigger strategy and