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Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells

Changes in gene regulation and expression govern orderly transitions from hematopoietic stem cells to terminally differentiated blood cell types. These transitions are disrupted during leukemic transformation, but knowledge of the gene regulatory changes underpinning this process is elusive. We hypothesized that identifying core gene regulatory networks in healthy hematopoietic and leukemic cells

Dispositional self-consciousness and hypnotizability

The abeyance of self-consciousness (SC) during hypnosis has beendiscussed as a central aspect of hypnosis, yet dispositional SC hasbeen very rarely evaluated as a correlate of hypnotizability. In thisstudy (N = 328), the authors administered the Harvard Group Scaleof Hypnotic Susceptibility (HGSHS), the Inventory Scale of HypnoticDepth (ISHD), and the Self-Consciousness Scale-Revised (SCS-R).Women

The influence of ammonia on the laminar burning velocities of methylcyclohexane and toluene : An experimental and kinetic modeling study

Laminar burning velocities of methylcyclohexane and toluene blended with ammonia have been determined using the heat flux method at atmospheric pressure and initial temperature of 338 K, over equivalence ratios ranging from 0.7 to 1.3 and ammonia blending fractions in the binary fuel mixtures from 0 to 90%. It was observed that the addition of ammonia to methylcyclohexane and toluene leads to a de

Atrial Fibrillation, Stroke, and Silent Cerebrovascular Disease : A Population-based MRI Study

Background and ObjectivesAtrial fibrillation (AF) has been associated with cognitive decline and dementia. However, the mechanisms behind these associations are not clear. Examination of cerebrovascular pathology on MRI may shed light on how AF affects the brain. This study aimed to determine whether AF is associated with a broad range of cerebrovascular diseases beyond the well-known association

Association Between Estrogen Receptors and GATA3 in Bladder Cancer : A Systematic Review and Meta-Analysis of Their Clinicopathological Significance

Background: Estrogen receptors alpha (ERα) and beta (ERβ) and the cooperating protein GATA-binding factor 3 (GATA3) have been implicated in bladder carcinogenesis and tumour progression. GATA3 and ER have been functionally linked in the establishment of luminal fate in breast tissue, but to date their relationship in bladder cancer has not been established. This information will be useful to advan

Effects of livestock and wildlife grazing intensity on soil carbon dioxide flux in the savanna grassland of Kenya

Although grazing is the primary land use in the savanna lowland of southern Kenya, the effects of grazing on soil carbon dioxide flux (RS) remain unclear. A 12-month study was conducted from January to December 2020 on the effects of six grazing intensities sites (overgrazed (OG), heavily grazed (HG), moderately grazed (MG), moderately to lightly grazed (M-LG), lightly grazed (LG) and no grazing (

Long-term exposure to transportation noise and risk of incident stroke : A pooled study of nine scandinavian cohorts

BACKGROUND: Transportation noise is increasingly acknowledged as a cardiovascular risk factor, but the evidence base for an association with stroke is sparse. OBJECTIVE: We aimed to investigate the association between transportation noise and stroke incidence in a large Scandinavian population. METHODS: We harmonized and pooled data from nine Scandinavian cohorts (seven Swedish, two Danish), total

Genes from oxidative phosphorylation complexes II-V and two dual-function subunits of complex I are transcribed in Viscum album despite absence of the entire mitochondrial holo-complex I

Mistletoes (Viscum) and close relatives are unique among flowering plants in having a drastically altered electron transport chain. Lack of complex I genes has previously been reported for the mitochondrial genome, and here we report an almost complete absence of nuclear-encoded complex I genes in the transcriptome of Viscum album. Compared to Arabidopsis with approximately 40 nuclear complex I ge

e-learning and web-based tools for psychosocial interventions addressing neuropsychiatric symptoms of dementia during the covid-19 pandemic in tokyo, japan : Quasi-experimental study

Background: Concern has been raised that the COVID-19 pandemic and consequent social distancing measures may increase neuropsychiatric symptoms in people with dementia. Thus, we developed and delivered an e-learning training course to professional caregivers on using a web-based tool for psychosocial interventions for people with dementia. Objective: The aim of our study was to evaluate the feasib

Does microbiological contamination of homografts prior to decontamination affect the outcome after right ventricular outflow tract reconstruction?

OBJECTIVES: Homografts are often in short supply. Today, European guidelines recommend that all tissues contaminated by any of 18 different bacteria and fungi be discarded before antibiotic decontamination has been conducted. The tissue bank in Lund uses more liberal protocols: It accepts all microbes prior to decontamination except multiresistant microbes and Pseudomonas species. The aim of this

Development of an EAT-Lancet index and its relation to mortality in a Swedish population

BACKGROUND: Current global food systems threaten human health and environmental sustainability. In 2019, the EAT-Lancet Commission on healthy diets from sustainable food systems defined the first global reference diet to improve both areas, but there is no consensus on how to quantify the EAT-Lancet reference diet as a diet index and its relation to mortality has not been widely studied.OBJECTIVE:

”A lot to fall back on” : Experiences of Dyspareunia among queer women

This study explores the subjective experiences of dyspareunia among queer women in Sweden. Ten semi-structured, in-depth interviews were conducted with five participants who were all interviewed on two separate occasions. Interviews were analyzed using thematic analysis (Braun & Clarke, 2006). Dyspareunia was described as affecting the participants’ sexual activities, intimate relationships, a

Effect of AMY1 copy number variation and various doses of starch intake on glucose homeostasis : data from a cross-sectional observational study and a crossover meal study

BACKGROUND: Copy number (CN) variation (CNV) of the salivary amylase gene (AMY1) influences the ability to digest starch and may influence glucose homeostasis, obesity and gut microbiota composition. Hence, the aim was to examine the association of AMY1 CNV with fasting glucose, BMI, and gut microbiota composition considering habitual starch intake and to investigate the effect of AMY1 CNV on the

Osmium and lithium isotope evidence for weathering feedbacks linked to orbitally paced organic carbon burial and Silurian glaciations

The Ordovician (∼487 to 443 Ma) ended with the formation of extensive Southern Hemisphere ice sheets, known as the Hirnantian glaciation, and the second largest mass extinction in Earth History. It was followed by the Silurian (∼443 to 419 Ma), one of the most climatically unstable periods of the Phanerozoic as evidenced by several large scale (>5‰) carbon isotope (δ13C) perturbations associated w

Computer-Based Training in Eating and Nutrition Facilitates Person-Centered Hospital Care : A Group Concept Mapping Study

Studies have shown that computer-based training in eating and nutrition for hospital nursing staff increased the likelihood that patients at risk of undernutrition would receive nutritional interventions. This article seeks to provide understanding from the perspective of nursing staff of conceptually important areas for computer-based nutritional training, and their relative importance to nutriti

Dynamic spatio‐temporal flow modeling with raster DEMs

A user-friendly high-resolution intermediate complexity dynamic and spatially distributed flow model is crucial in urban flood modeling. Planners and consultants need to improve the accuracy of floods and estimation of risks. A new flow model will serve as a rapid tool to improve identification of these. This article provides a detailed explanation of a model based on a multiple flow algorithm. MoA user-friendly high-resolution intermediate complexity dynamic and spatially distributed flow model is crucial in urban flood modeling. Planners and consultants need to improve the accuracy of floods and estimation of risks. A new flow model will serve as a rapid tool to improve identification of these. This article provides a detailed explanation of a model based on a multiple flow algorithm. Mo

Greening higher education? From responsibilization to accountabilization in the incorporation of sustainability in higher education

Purpose: This study aims to investigate how sustainability has been incorporated – or mainstreamed - in a school at one university through techniques of responsibilization and accountabilization. Design/methodology/approach: Inspired by the extended case study methodology, the authors participated, observed and analyzed two audit-inspired processes, whose aims included ensuring that sustainability

Collection and Reporting of Patient-reported Outcome Measures in Arthroplasty Registries: Multinational Survey and Recommendations

BACKGROUND: Patient-reported outcome measures (PROMs) are validated questionnaires that are completed by patients. Arthroplasty registries vary in PROM collection and use. Current information about registry collection and use of PROMs is important to help improve methods of PROM data analysis, reporting, comparison, and use toward improving clinical practice. QUESTIONS/PURPOSES: To characterize PR

The 10-year incidence of hypertension across blood pressure categories in a population-based cohort in southwestern Sweden

Background: To explore the determinants of incident hypertension, and especially the impact of baseline blood pressure categories, in a representative Swedish population. Methods: A 10-year longitudinal study of residents aged 30–74. Blood pressures were measured and categorized according to ESH guidelines with optimal blood pressure < 120/80 mmHg, normal 120–129/80–84 mmHg, and high normal 130–13

Urinary extracellular vesicles : Assessment of pre-analytical variables and development of a quality control with focus on transcriptomic biomarker research

Urinary extracellular vesicles (uEV) are a topical source of non-invasive biomarkers for health and diseases of the urogenital system. However, several challenges have become evident in the standardization of uEV pipelines from collection of urine to biomarker analysis. Here, we studied the effect of pre-analytical variables and developed means of quality control for uEV isolates to be used in tra