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Structural and functional neuroimaging changes associated with cognitive impairment and dementia in Parkinson's disease

This study seeks a better understanding of possible pathophysiological mechanisms associated with cognitive impairment and dementia in Parkinson's disease using structural and functional MRI. We investigated resting-state functional connectivity of important subdivisions of the caudate nucleus, putamen and thalamus, and also how the morphology of these structures are impacted in the disorder. We f

Polarization effects in Raman spectroscopy of light-absorbing carbon

Raman spectroscopy is widely used for characterization of carbon-based mate- rials including light-absorbing carbonaceous (LAC) matter. However, informa- tion on polarization properties of these materials are generally lacking, and often the polarization characteristics of experiments are not presented in the literature thereby giving uncertainty to presented data. In this work, the polari- zation

Femoral strength and strains in sideways fall : Validation of finite element models against bilateral strain measurements

Low impact falls to the side are the main cause of hip fractures in elderly. Finite element (FE) models of the proximal femur may help in the assessment of patients at high risk for a hip fracture. However, extensive validation is essential before these models can be used in a clinical setting. This study aims to use strain measurements from bilateral digital image correlation to validate an FE mo

Potential immunoregulatory role of T and dendritic cells in cancer : Investigations based on transcriptional analysis

Cancer is a complex disease with various genetic and epigenetic driving factors. Cancer cells form a favored microenvironment to sustain their uncontrolled behavior leading to abnormal growth. With standard treatment including chemotherapy, relapse risk is high due to the resistance that cancer cells can develop against chemotherapy agents. Immuno-oncological therapeutics, as alternatives, have sh

IL-2Rβγ signalling in lymphocytes promotes systemic inflammation and reduces plasma cholesterol in atherosclerotic mice

BACKGROUND AND AIMS: The relationship between inflammation and lipid metabolism is complex and bidirectional. Lymphocyte-driven inflammation has been shown to modulate both atherosclerotic plaque development and cholesterol levels, but the mechanisms are incompletely understood.METHODS: The cardiometabolic effects of IL-2Rβγ signalling in atherosclerotic Apoe-/- mice were investigated by treatment

Policies in Hard Times: Assessing the Impact of Financial Crises on Structural Reforms

It is commonly argued that crises open up a window of opportunity to implement policies that otherwise would not have the necessary political backing. The argument goes that the political cost of economic and social reforms declines as crises unravel structural problems that need to be urgently rectified and the public is more willing to bear the pains associated with such reforms. This paper cast

Making a (Political) Career: Young Party Members and Career‐Related Incentives for Party Membership

Few empirical studies have investigated career‐related incentives for party membership, including for young party members. Through the lens of rational choice, we ask what career‐related incentives young and active party members consider when calculating costs and benefits of party membership. We argue for a broad understanding of career‐related incentives, including careers outside party politics

Investigations on Membrane Fouling and Cleaning in Ultrafiltration Processes in Lignocellulosic Biorefineries

The current fossil-based economy must be transformed into a bio-based circular economy. A cornerstone of this transformation is the conversion of pulp and paper mills into lignocellulosic biorefineries that allow not only the production of pulp, paper, and electricity, but also novel biochemicals. Highly selective, electrifiable, and low-energy-consuming separation technologies will be key in the

Reasoning by Exclusion

Representing mutually exclusive alternatives (“A or B”), ruling out one or multiple alternatives (“not A”), and thereby concluding that the remaining alternative must be true (“therefore B”).

Machinability of Single-phase Materials : Surface integrity and tool wear analysis

The quality and performance of products are particularly important in sectors such as research facilities and in the nuclear, military and space industries. These sectors make use of high-performance materials that are uncommon in other contexts and therefore place high requirements on personnel, machines and tools. While tool manufacturers have readily available tool selection guides and cutting

Att aktivera och synliggöra elevers förkunskaper (generell text)

För att elever ska kunna ta till sig ny kunskap behöver deras tidigare kunskaper aktiveras och synliggöras. Både den inledande bedömningen och den kontinuerliga bedömningen av elevers tidigare erfarenheter och kunskaper är viktiga resurser och utgör en viktig grund för fortsatt lärande. Varje nytt arbetsområde behöver starta en rörelse i undervisningen, med utgångspunkt i det konkreta och vardagli

Biogeografisk uppföljning 2020 av dagfjärilar inom habitatdirektivet

Rapporten sammanfattar fjärilsinventeringar utförda 2020 inom Biogeografisk uppföljning som drivs av Naturvårdsverket. I fjällområdet kunde totalt 49 ytor inventeras. Sammanlagt noterades 151 högnordiska blåvingar på 22 inventerade ytor, 53 dvärgpärlemorfjärilar på 25 ytor och minst 1 fjällsilversmygare noterades på 3 inventerade ytor. Svartfläckig blåvinge observerades på 15 av 50 inventerade lok

Att aktivera och synliggöra elevers förkunskaper (ämnesspecifik text: musik)

En central del av undervisningen är att varje nytt arbetsområde inleds med att elevers förkunskaper aktiveras och synliggörs. I musikämnet kan reflektion och samtal om musik och musikminnen vara ett sätt att synliggöra elevers kunskaper och förförståelse om musik. Med dessa förkunskaper som grund får eleverna sedan möjlighet att utvecklas vidare när det gäller kunskaper, språk och identitet.