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CYTOGENETIC AND MOLECULAR GENETIC CHARACTERIZATION OF LIPOMAS

Popular Abstract in Swedish Cancer uppstår via genetiska förändringar som leder till ohämmad reglering av celltillväxt. Tumörer i mjukdelar utgör en grupp av solida tumörer, med över 100 histologiska typer. Mjukdelstumörer uppstår från mesenkymal vävnad, som inkluderar fett, bindväv, muskulatur, och det perifera nervsystemet. Mjukdelstumörer är en extremt heterogen grupp, både vad gäller morfologiThe focus of this thesis was to study cytogenetic and molecular genetic aberrations in lipomas. For this purpose, chromosome banding analysis, fluorescence in situ hybridization (FISH), as well as high resolution single nucleotide polymorphism (SNP)–arrays were used to identify recurrent chromosomal aberrations in lipomas. The possible molecular targets for these aberrations were further studied t

Adaptive Rate-Maximizing Channel-Shortening for ISI Channels

We consider detection over intersymbol interference channels that are unknown at the receiver. For such a kind of systems, we consider an alternative approach to the design of a reduced-complexity receiver based on channel shortening without the explicit estimation of the channel impulse response. The proposed solution allows a simplification of the receiver architecture and a faster convergence f

Persistently Altered Brain Mitochondrial Bioenergetics After Apparently Successful Resuscitation From Cardiac Arrest.

Although advances in cardiopulmonary resuscitation have improved survival from cardiac arrest (CA), neurologic injury persists and impaired mitochondrial bioenergetics may be critical for targeted neuroresuscitation. The authors sought to determine if excellent cardiopulmonary resuscitation and postresuscitation care and good traditional survival rates result in persistently disordered cerebral mi

Visualization of regulations to support design and quality control - a long-term study

The aim of the study was to visualize design regulations of furniture by means of interactive technology based on earlier studies and practical examples. The usage of the visualized regulations was evaluated on two occasions: at the start when the first set of regulations was presented, and after six years of usage of all regulations. The visualized regulations were the result of a design process

Non-Invasive Measures of Heart Failure

Popular Abstract in Swedish Hjärtsvikt är en sjukdom som beror på att hjärtat inte kan pumpa ut tillräckligt med blod till kroppens vävnader. I Sverige drabbas årligen 30000 personer av hjärtsvikt, och prognosen är jämförbar med de vanligaste cancerformerna. Trots att det är så vanligt och allvarligt, saknas i dagsläget objektiva mått på hjärtsvikt – det finns alltså ingen ”linjal” för att mäta huHeart failure is a clinical syndrome characterized by an inability of the heart to meet the metabolic demands of the body. Approximately 1-2% of the population in the western society has the diagnosis, and the 5-year mortality rate is comparable with the common cancer diagnoses. The lack of reliable objective measures of heart failure motivates research in this direction. Blood flow is an essentia

Kollektbönen i svenska evangelieböcker 1562-2003: En analys av förändringar och deras orsaker

The object of this study is to investigate how and why the collects in Swedish lectionaries between 1562 and 2003 (lectionaries used in the Church of Sweden include both lessons and collects) have been changed. It focuses on the twentieth and twenty-first centuries, as the transformation of the collects really starts with the lectionary issued in 1921. Collects from a number of editions of the lec

Greater loss of von Economo neurons than loss of layer II and III neurons in behavioral variant frontotemporal dementia.

Previous studies have shown a selective reduction of von Economo neurons (VENs) in behavioral variant frontotemporal dementia (bvFTD). However, the alleged selectivity rests on the comparison between VENs and other neurons in cortical layer V, while it has been established that neurons in the superficial cortical layers (I-III) are particularly affected in bvFTD. The purpose of this study was to e

A Panel of Kallikrein Marker Predicts Prostate Cancer in a Large, Population-Based Cohort Followed for 15 Years without Screening

Background: Prostate-specific antigen (PSA) has modest specificity for prostate cancer. A panel of four kallikrein markers (total PSA, free PSA, intact PSA, and kallikrein-related peptidase 2) is a highly accurate predictor of biopsy outcome. The clinical significance of biopsy-detectable cancers in men classified as low-risk by this panel remains unclear. Methods: The Malmo Diet and Cancer study

Health-related quality of life in Swedish children and adolescents with limb reduction deficiency

Aim: To investigate health-related quality of life (HRQoL) in young persons with limb reduction deficiency (LRD). Methods: One hundred and forty children with LRD aged 8-16 answered the DISABKIDS questionnaire for children with chronic health conditions. Of their parents, 137 answered a corresponding questionnaire concerning their child. Results: Compared to reference data from children with other

A Pilgrimage to the Past : Johannes Bureus and the Rise of Swedish Antiquarian Scholarship, 1600-1650

At the end of the eighteenth century, Edward Gibbon described the antiquarian scholars of previous generations as men of “profound learning and easy faith.” His exemplar was the Swedish polymath Olof Rudbeck, who in a series of frantic and combative tomes sought to portray Sweden as the model for Plato’s Atlantis and the seething cultural cauldron from which Western civilization had emerged. A Pil

Diagnosis-prescribing surveys in 2000, 2002 and 2005 in Swedish general practice: Consultations, diagnosis, diagnostics and treatment choices

The aim of this study is to present diagnostic patterns, diagnostics used and antibiotic treatment in relation to guidelines in 3 repeated diagnosis-prescription studies conducted simultaneously in general practice in 5 Swedish counties, during 1 week in November 2000, 2002 and 2005. General practitioners (GPs) at the participating health centres were asked to complete a form for all patients with

Advanced clinical MRI for better outcome in epilepsy surgery. Focusing on fMRI and prediction of verbal memory decline.

Abstract Aim: The aim of the thesis was to evaluate the use of advanced MRI technology to improve results of epilepsy surgery, with focus on language and memory functions. Methods: In paper I, 25 patients with drug-resistant epilepsy were retrospectively included in the study for having been referred to high resolution 3T MRI with and without surface coils. The surface coils were placed over the s

Genetic algorithm approach for QoS-based tree topology construction in IEEE 802.16 mesh networks

The topological characteristics of an IEEE 802.16 mesh network including the tree’s depth and degree of its nodes affect the delay and throughput of the network. To reach the desired trade-off between delay and throughput, all potential trees should be explored to obtain a tree with the proper topology. Since the number of extractable tree topologies from a given network graph is enormous, we use