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Hyperresponsiveness and inflammation are major pathophysiological features of both allergic rhinitis and asthma. The mechanisms behind these are not fully understood. The aims of this thesis were to investigate if cytokines involved in the allergic response can induce airway hyperreactivity by affecting the airway smooth muscle directly and to identify novel mediators involved in allergic airway i
Background and Aim: A recent study in Indian subjects suggested common variants in apolipoprotein C3 (APOC3) (T-455C at rs2854116 and C-482T at rs2854117) to contribute to non-alcoholic fatty liver disease (NAFLD), plasma apoC3 and triglyceride concentrations. Our aim was to determine the contribution of genetic variation in APOC3 on liver fat content and plasma triglyceride and apoC3 concentratio
ATP and ADP inhibit, in varying degrees, several dehydrogenases of the central carbon metabolism of Lactococcus lactis ATCC 19435 in vitro, i.e. glyceraldehyde-3-phosphate dehydrogenase (GAPDH), lactate dehydrogenase (LDH) and alcohol dehydrogenase (ADH). Here we demonstrate mixed inhibition for GAPDH and competitive inhibition for LDH and ADH by adenine nucleotides in single inhibition studies. T
Premise of the study: Storage oil (triacylglycerol) accumulates in tissues such as the embryo and endosperm of seeds and the fruit mesocarp, but seldom in underground organs. As a rare exception, cultivated variants of yellow nutsedge (Cyperus esculentus) contain high amounts of both oil and starch in the mature tubers. Methods: Biochemical analyses and light and electron microscopy were used to s
SUMMARY: Models of service encounters are often fraught by reductionism, describing business relationships as mathematical combinations of dyadic constellations. Metaphors of ideal social relationships (marriages or friendships) are highlighted to stress normative aspects of equal, balanced and long-term business partnerships. However, these approaches are limited in their analytical sensitivity,
This report deals with strength tests of glulam beams with quadratic holes with rounded corners. A total of 36 individual tests were carried out, divided into nine test series with four nominally equal tests in each test series. There were four para\-meters varied within these test series: beam size, bending moment to shear force ratio, material strength class and also hole placement with respect
Huntington's disease patients have a number of peripheral manifestations suggestive of metabolic and endocrine abnormalities. We, therefore, investigated a number of metabolic factors in a 24-hour study of Huntington's disease gene carriers (premanifest and moderate stage II/III) and controls.
Persistent, itching nodules have been reported to appear at the injection site after allergen-specific immuno-therapy with aluminium-precipitated antigen extract, occasionally in conjunction with contact allergy to aluminium. This study aimed to quantify the development of contact allergy to aluminium during allergen-specific immunotherapy. A randomized, controlled, single-blind multicentre study
To study retinal function and morphology in ABCA4 carriers to investigate if ABCA4 carriership is associated with any functional or morphological changes and, if so, to explore whether certain mutations may be associated with particularly severe alterations.
We consider scenarios in the next-to-minimal supersymmetric model (NMSSM) where the CP-odd and charged Higgs bosons are very light. As we demonstrate, these can be obtained as simple deformations of existing phenomenological MSSM benchmarks scenarios with parameters defined at the weak scale. This offers a direct and meaningful comparison to the MSSM case. Applying a wide set of up-to-date constra
We present a study of neural network architectures able to internally simulate perceptions and actions. All these architectures employ the novel Associative Self-Organizing Map (A-SOM) as a perceptual neural network. The A-SOM develops a representation of its input space, but in addition also learns to associate its activity with an arbitrary number of additional (possibly delayed) inputs. One arc
Peasant revolts in Europe in the period 1000–1800 often involved militarized peasants. In Western Europe, this appeared in particular between 1300 and 1500 in connection with the late medieval process of militarization of the population. After the sixteenth century a similar process took place in central and Eastern Europe, where the revolts tended to be dominated by border and frontier population
This article introduces the concept of Time Travel as a new way to approach the past in our age. The article deals with the question: What role does the past play for people in our time? The time travel discussion focusses on the following themes: Time travel between materality and virtuality; Time travel on the market of experiences; Designing time travel; Evaluating time travel.
Pentoxifylline is a haemorheologic drug with complex pharmacokinetics and pharmacodynamics due to both reversible metabolism and the formation of active metabolites. In humans, pentoxifylline is metabolised to at least seven phase 1 metabolites (M1-M7). The reversible metabolism of pentoxifylline to the enantiomers of M1 has only been partly studied. This thesis investigates the pharmacokinetics
Although the U-Pb zircon chronometer has been widely used for dating metamorphism in moderate to high-grade rocks, it is generally difficult to link the U-Pb age of zircon to specific metamorphic reactions. In this study, the initial Hf isotopic composition of secondary zircon is compared with the evolution of Hf isotopic composition of the bulk sample, back-projected from the measured value throu
Background: The onset of birth in humans, like other apes, differs from non-primate mammals in its endocrine physiology. We hypothesize that higher primate-specific gene evolution may lead to these differences and target genes involved in human preterm birth, an area of global health significance. Methods: We performed a comparative genomics screen of highly conserved noncoding elements and identi
