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Popular Abstract in Swedish Vid genterapi för man in nya gener i en individs celler. Detta kan göras med hjälp av modifierade virus. Dessa virus kan föra in den nya genen, den såkallade transgenen, in i värdcellen men inte bilda nya viruspartiklar. I många fall är det viktigt att begränsa i vilka celler som transgenen uttrycks, då det producerade proteinet kan ge bieffekter i andra celltyper. Det Gene therapy is a promising therapeutic tool for many diseases of the CNS. Lentiviral vectors are particularly attractive since this vector type can transduce both dividing and non-dividing cells, have a relatively large cloning capacity, can sustain long-term transgene expression and have low immunogenicity. The specificity of the vector is however important to avoid potential off-target effects

Context. Understanding the history and the evolution of the Milky Way is one of the main goals of modern astrophysics. In particular, the formation of the Galactic disc is a key problem of Galactic archaeology. Aims. We study the velocity dispersion behaviour of Galactic disc stars as a function of the [Mg/Fe] ratio, which for small metallicity bins can be used as a proxy of relative age. This key

Critics suggest that Reducing Emissions from Deforestation and forest Degradation (REDD+) may not generate improvements in well-being for participating stakeholders, and may in fact undermine indigenous rights. To ensure positive social benefits from REDD+ projects, the United Nations REDD Programme has proposed core safeguards, including local stakeholder participation; free, prior, and informed

Ethnographically inspired methods have in recent years been successfully applied in Information Science (IS) research on different forms of social media related practices (c.f. Sundin & Francke 2009a; 2009b, Kjellberg 2010). This paper aims to contribute to an emerging discussion on the use of this methodological approach for analysing and comprehending consequences of the 2.0-turn in public l

Background: Pediatric intestinal biopsy procedures including considerable transpharyngeal manipulation of a wire-guided metal capsule require adequate sedation or anesthesia. This retrospective cohort study was designed to evaluate intravenous sedation with ketamine and low-dose midazolam in young children undergoing these procedures before and also after discharge from the hospital. Methods: A t

Customers are important stakeholders for any company; yet, they seem not to be widely discussed in merger and acquisition research. This chapter synthesizes the current body of research on customers in mergers and acquisitions through presenting a systematic literature review. The chapter is based on a systematic literature review resulting from a search in EBSCO Host for any research item that re

Isoprene emission from Sphagnum species naturally growing at different positions above the water table were measured in a subarctic peatland and at monoliths from a temperate bog. Our objectives were to investigate (1) whether emission rates were species and/or moisture dependent, and (2) whether short-term temperature history had an influence on emission capacity. We expected greater emission cap

Interaction is an integral part of all music. Interaction is part of listening, of playing, of composing and even of thinking about music. In this thesis the multiplicity of modes in which one may engage interactively in, through and with music is the starting point for rethinking Human-Computer Interaction in general and Interactive Music in particular. I propose that in Human-Computer interactio

Tumor cell death potentially engages with the immune system. However, the efficacy of anti-tumor chemotherapy may be limited by tumor-driven immunosuppression, e.g., through CD25(+) regulatory T cells. We addressed this question in a mouse model of mesothelioma by depleting or reconstituting CD25(+) regulatory T cells in combination with two different chemotherapeutic drugs. We found that the effi

In international research there is a near consensus that the importance of cities is growing. As the policymakers of contemporary cities redirect their policy orientations away from the goal of redistribution towards achieving economic competitiveness, and as they introduce new structures of governance, they are becoming more and more committed to entrepreneurial city politics. However, both the i

To gain entry into target cells, HIV-1 binds to CD4 via the viral glycoprotein gp120. This interac-tion initiates a series of events including binding of a coreceptor, CCR5 and/or CXCR4, and ulti-mately leads to gp41-mediated fusion of the viral and cell membranes. CCR5-restricted (R5) vi-ruses predominate in early, asymptomatic stages of the infection. Emergence of viruses able to use CXCR4 inste

A polygonal finite-element formulation is applied to solve electromechanically coupled inhomogeneous boundary value problems for polycrystalline materials. Each grain is discretised by one single polygonal finite element, which allows the efficient simulation of general boundary value problems which still resolves individual grains in space. The constitutive model proposed for switching in piezoce

Background: Risk factors for hip fracture are well studied because of the negative impact on patients and the community, with mortality in the first year being almost 30% in the elderly. Age, gender and fall risk-increasing drugs, identified by the National Board of Health and Welfare in Sweden, are well known risk factors for hip fracture, but how multimorbidity level affects the risk of hip frac

The position generator is a widespread method for measuring latent social capital in which respondents are queried about contacts on a list of occupations predefined by the analyst. We separate out the unique contribution of each occupation to aggregated measures of social capital. It turns out that this contribution varies vastly: knowing a person in some occupations provides substance to measure

We used molecular dynamics simulation to model the effect of urea and thiourea on the solvent quality of aqueous solutions with respect to cellulose. A model system consisting of a periodically replicated cellulose molecule of effectively infinite degree of polymerization immersed in aqueous (thio-)urea solution was considered. Kirkwood-Buff theory, which relates the pair distribution functions to

Software development companies operating in market-driven domains need to deliver new and appealing software products at an increasing rate in order to stay competitive. This requires fast and efficient development of software for which the requirements are based on ever-changing market demands. Agile development claims to achieve increased development efficiency by performing the requirements eng

In this study, numerical simulations are conducted to investigate the effects of bowed outlet guide vanes (OGVs) on endwall heat transfer and aerodynamic performance. Both on- and off-design conditions are studied. For bowed vanes, the bowed angle varies from 10 degrees to 40 degrees and the normalized bowed height ranges from 0.1 to 0.3. Results are included for Nusselt number distributions on th