Expression of fibroblast growth factor-8 (FGF-8) is increased in a large number of breast cancers. In in vitro and in vivo breast cancer models FGF-8 promotes growth, invasion and angiogenesis. In the present work we have studied the mechanisms by which FGF-8b and its receptors (FGFR1-3) promote breast cancer cell growth using S115 murine and human MCF-7 breast cancer cell lines in in vitro and i

Background: Apolipoprotein M (apoM) may have potential antiatherosclerotic properties. It has been reported that apoM expression could be regulated by many intracellar and extracellar factors. In the present study we further investigated regulation of apoM expression in Caco-2 cells stimulated by a liver X receptor (LXR) agonist, TO901317. Materials and methods: Caco-2 cells were cultured in the p

Objective. There is an increased risk of gastrointestinal carcinoma and smoking-related diseases after partial gastrectomy for peptic ulcer disease. The purpose of this study was to evaluate long-term cancer incidence and mortality after parietal cell vagotomy (PCV), a surgical method with a low rate of side effects, but creating hypochlorhydria in the stomach mimicking long-term treatment with an

Background: The development of spasticity with age in children with cerebral palsy (CP) has, to our knowledge, not been studied before. In 1994, a register and a health care program for children with CP in southern Sweden were initiated. In the programme the child's muscle tone according to the modified Ashworth scale is measured twice a year until six years of age, then once a year. We have used

Edge aliasing continues to be one of the most prominent problems in real-time graphics, e.g., in games. We present a novel algorithm that uses shared memory between the GPU and the CPU so that these two units can work in concert to solve the edge aliasing problem rapidly. Our system renders the scene as usual on the GPU with one sample per pixel. At the same time, our novel edge aliasing algorithm

A method for determination of polycyclic aromatic hydrocarbons (PAHs) from aerosols was developed. Instead of conventionally used non-polar or slightly polar phenylmethylpolysiloxane column a highly polar, highly substituted, cyanopropyl column (VF-23 MS) was used for separation of PAHs. Based on hollow fiber micro-porous membrane liquid-liquid extraction (HF-MMLLE) a method was developed for samp

mass close-in planets, despite the latter being exceedingly common. Two migration channels for hot Jupiters have been proposed: through a protoplanetary gas disk or by tidal circularization of highly eccentric planets. We show that highly eccentric giant planets that will become hot Jupiters clear out any low-mass inner planets in the system, explaining the observed lack of such companions to hot

Popular Abstract in Swedish Bränslecellen uppfanns redan 1838, det kommersiella genombrottet dröjde till 2007, den framtida potentialen är mycket lovande Domedagsprofetior angående växthuseffektens betydelse för livet på jorden når oss via media allt oftare. Bränsleceller är mycket lovande för ett framtida miljövänligt samhälle. Hög energieffektivitet och inga utsläpp av koldioxid, kväveoxider elFuel cells are electrochemical devices that directly transform chemical energy into electricity. They are promising for future energy systems, since they are energy efficient, able to use renewable fuels and, when hydrogen is used as fuel, there are no direct emissions of greenhouse gases. Various improvements are made during the recent years, however the technology is still in the early phases of

Popular Abstract in Swedish Populärvetenskaplig sammanfattning: Det genomgående temat i avhandlingen är hur handeln mellan den Europeiska Unionen (EU) och utvecklingsländer kan öka. Två olika policyalternativ utvärderas: så kallade handelspreferenser samt förenklingar av handelsprocedurer. Handelspreferenser innebär i sin enklaste form att höginkomstländer kräver lägre tullar på importvaror somThe main theme of the thesis is how to increase trade between the European Union (EU) and developing countries. Two available policy options are assessed: trade preferences and trade facilitation. Chapter 1 offers a broad discussion of these policies, and concludes that while trade preferences, which once dominated North-South trade relations, are at a risk of becoming obsolete, trade facilitation

The present study investigated the correlation among genetic polymorphisms of the proximal promoter region of apolipoprotein M (apoM) gene, the polymorphisms in relation to apoM expressions and the susceptibility to coronary artery diseases (CAD) in a Han Chinese population. Four common polymorphic sites, i.e., T-1628G, C-1065A, T-855C and T-778C, were confirmed, and a new deletion mutation C-724d

abstract is not available

In 1914 Professor Nathan Soderblom was elected archbishop of the Church of Sweden. His consecration took place in Uppsala Cathedral just months after the beginning of World War I. In 1925, he convened an ecumenical meeting in Stockholm that came to shape the ecumenical movement for decades to come. The peace question remained at the heart of his episcopate as long as it lasted. In this article, An

Arginine-rich cell penetrating peptides (ARCPPs) are known to quickly permeate cell membranes through a non-endocytotic pathway. Potential clinical applications of this facility have prompted enormous effort, both experimental and theoretical, to better understand how ARCPPs manage to overcome the prodigious thermodynamic cost of lipid bilayer permeation by these highly charged peptides. In this w