Popular Abstract in Swedish Senare års forskning har klart och entydigt pekat på njurens viktiga roll i utvecklingen av högt blodtryck. Det är mycket sannolikt att det föreligger flera av varandra oberoende mekanismer som förklarar uppkomsten av högt blodtryck, men det är möjligt att flera av dessa, på en organfysiologisk, cellfysiologisk eller genetisk nivå kan ha gemensamma patofysiologiska länkStudies were conducted to investigate the role of macula densa (MD)-derived nitric oxide (NO) in regulation of the glomerular filtration (GFR) through the tubuloglomerular feedback (TGF) mechanism. Immunocytochemical localization of the neuronal isoform of NO synthase (NOS) in the kidney showed that this isoform was exclusively located in MD cells. Whole kidney clearance measurements of GFR and mi

The main purpose of this dissertation is to describe how terminally ill patients experienced their situation, and what their views about the future were. Further, the experiences and attitudes of relatives of such patients, and of health care professionals, were also central. Focus was on existential issues, such as autonomy, meaning, guilt, relations, dignity, and communication. In the first pape

Disposition ascription has been discussed a good deal over the last few decades, as has the revisionary metaphysical view of ordinary, persisting objects known as 'fourdimensionalism'. However, philosophers have not merged these topics and asked whether four-dimensional objects can be proper subjects of dispositional predicates. This paper seeks to remedy this oversight. It argues that, by and lar

In this thesis, the fluid dynamic properties of the conventional Rushton turbine and another impeller type, the Scaba Radial flow Gas dispersing Turbine (with six concave blades) are compared. For comparison, point-wise velocity measurements were made in the discharge of the two turbine types using Hot-Wire Anemometry in constant temperature mode (CTA) with a split film probe. For the time-average

Due to the increasing test data volume needed to test core-based System-on-Chip, several test scheduling techniques minimizing the test application time have been proposed. In contrast to approaches where a fixed test set for each core is assumed, we explore the possibility to use overlapping test patterns from the tests in the system. The overlapping tests serves as alternatives to the original d

Popular Abstract in Swedish Sammanfattning på svenska Stafylokocker ingår i vår normala bakterieflora på hud och slemhinnor, men kan också ge upphov till infektioner. Staphylococcus aureus, den gula stafylokocken, är den vanligaste orsaken till sårinfektioner och "sjukhussjuka", och orsakar allvarliga djupa infektioner i ben, hjärta och andra inre organ, samt blodförgiftning. S. epidermidis, den vCoagulase-negative staphylococci (CoNS), in particular, Staphylococcus epidermidis, have emerged as major nosocomial pathogens associated with infections of implanted medical devices. These organisms, which are among the most prevalent bacteria of the human skin and mucous membrane microflora, gain access to the surface of the implant at the insertion. However, the subsequent infection may erupt u

Extracorporeal adsorption (ECAT) is a novel strategy to reduce activity in whole body (WB), blood and radiosensitive organs by removing the excess of radiolabeled and biotinylated monoclonal antibody (MAb) from blood so that tumor/normal tissue ratio (T/N) could be improved. By increasing T/N, higher amounts of radiolabeled MAb might be administered, making it possible to treat disseminated carcin

Popular Abstract in Swedish Alla celler behöver energi och de skaffar den på olika sätt, t. ex. från oxidering av mat eller från solljus. Adenosin trifosfat (ATP), som kallas för cellens energivaluta, kan dock inte syntetiseras direkt från mat eller ljus. Nästan alla organismer utnyttjar proteinkomplex i form av en andningskedja som sitter i membranet för att alstra en proton potential. Det kan liComplex I is the mitochondrial enzyme complex that oxidizes NADH produced in the citric acid cycle and reduces quinone in the membrane, coupled to proton pumping out of the mitochondrial matrix, creating a membrane potential. This process generates about 40% of the energy used by living organisms. High-resolution structures of complex I recently became available, but the molecular mechanism behind

Popular Abstract in Swedish Kan immunförsvaret orsaka ledsjukdomar? Ett väl fungerande immunsystem är en förutsättning för att kroppen ska kunna bekämpa diverse sjukdomar orsakade av t. ex. virus och bakterier. En grundläggande egenskap hos immunsystemet är dess förmåga att kunna skilja på vad som är kroppens egna celler och molekyler och vad som är främmande. Man tror att vissa sjukdomar, så kalCollagen-induced arthritis (CIA) is a mouse model for rheumatoid arthritis, in which autoimmunity is induced by immunization with type II collagen (CII), a cartilage-specific protein. In the present work, alpha/beta T cells were shown to be required for CIA and for the production of anti-CII IgG antibodies, whereas gamma/delta T cells were neither necessary nor sufficient for development of CIA. A

Good health is crucial for human and economic development. In particular poor health in childhood seems to be of utmost concern since it causes irreversible damage and have implications later in life. Recent research suggests globalization is a strong force affecting adult and child health outcomes. Yet, there is much unexplained variation with respect to the globalization eect on child health, in