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We show that the centrosome- and microtubule-regulating protein γ-tubulin interacts with E2 promoter binding factors (E2Fs) to modulate E2F transcriptional activity and thereby control cell cycle progression. γ-Tubulin contains a C-terminal signal that results in its translocation to the nucleus during late G(1) to early S phase. γ-Tubulin mutants showed that the C terminus interacts with the tran

Given the highly variable behavior and clinical course of prostate cancer (PCa) and the multiple available treatment options, a personalized approach to oncologic risk stratification is important. Novel genetic approaches offer additional information to improve clinical decision making.

The effect of future climate scenarios on surface and groundwater resources was simulated using a model- ing approach for an artificial recharge area in arid southern Iran. Future climate data for the periods of 2010–2030 and 2030–2050 were acquired from the Canadian Global Coupled Model (CGCM 3.1) for scenarios A1B, A2, and B1. These scenarios were adapted to the studied region us- ing the delta-

When searching for resources in heterogeneous environments, animals must rely on their abilities to detect the resources via their sensory systems. However, variation in the strength of the sensory cue may be mediated by the physical size of the resource patch. Patch detection of insects are often predicted by the scaling of sensory cues to patch size, where visual cues has been proposed to scale

The solvation of alkali-halides in water clusters at nanoscale is studied by photoelectron spectroscopy using synchrotron radiation. The Na 2p, K 3p, Cl 2p, Br 3d, and I 4d core level binding energies have been measured for salt-containing water clusters. The results have been compared to those of alkali halide clusters and the dilute aqueous salt solutions. It is found that the alkali halides dis

Ectomycorrhizal fungi are thought to have a key role in mobilizing organic nitrogen that is trapped in soil organic matter (SOM). However, the extent to which ectomycorrhizal fungi decompose SOM and the mechanism by which they do so remain unclear, considering that they have lost many genes encoding lignocellulose-degrading enzymes that are present in their saprotrophic ancestors. Spectroscopic an

This article contributes to debates about ethical and methodological dilemmas experienced in international development studies. It departs from a research experience based on a longitudinal study, the Reality Check Approach, that puts intimacy, immersion and consensus at its core. These concepts signify an ethically motivated approach that aims to give voice' to people living in poverty. They also

This REgional Carbon Cycle Assessment and Processes regional study provides a synthesis of the carbon balance of terrestrial ecosystems in East Asia, a region comprised of China, Japan, North and South Korea, and Mongolia. We estimate the current terrestrial carbon balance of East Asia and its driving mechanisms during 1990-2009 using three different approaches: inventories combined with satellite

Surface plasmons, the quanta of the collective oscillations of free electrons at metal surface, can be easily tuned by changing the surrounding dielectric materials, which is well known for metal nanoparticles and metal surfaces, but less is known for one-dimensional metal nanowires. Here, we find an extremely large tunability of surface plasmons on Ag nanowires with a beat period of the near-fiel

Objectives: To explore reasons for institutionalization of people with dementia according to informal caregivers as well as variation in reasons between countries. Design: An explorative cross-sectional study was conducted in 8 European countries. Setting: Per country, a minimum of 3 long term care facilities, offering care and accommodation as a package, participated in this study. Participating

The presence of Muslim populations in Western European societies is a relatively new phenomenon which begs the question how these societies treat religious minorities. This article on the Swedish case begins with a brief history of the historical development of Sweden from a religious state based on the Lutheran faith to today’s secular state in which state and religion are officially separated. T

This paper presents a flow that is suitable to estimate energy dissipation of digital standard-cell based designs which are determined to be operated in the sub-threshold regime. The flow is applicable on gate-level netlists, where back-annotated toggle information is used to find the minimum energy operation point, corresponding maximum clock frequency, as well as the dissipated energy per clock

In lumbar disc herniation surgery, dural lesions seem to be the most common complication today. Studies on incidence of and outcome after a dural lesion are mainly based on retrospective studies. In a prospective study within the framework of the Swedish Spine Register, 4,173 patients operated on for lumbar disc herniation were evaluated using pre- and 1-year postoperative protocols and complicati

Background: The spectrum of disorders of the brain is large, covering hundreds of disorders that are listed in either the mental or neurological disorder chapters of the established international diagnostic classification systems. These disorders have a high prevalence as well as short- and long-term impairments and disabilities. Therefore they are an emotional, financial and social burden to the

Large parity-violating longitudinal single-spin asymmetries A(L)(e+) = 0.86(-0.14)(+0.30) and Ae(L)(e-) = 0.88(-0.71)(+0.12) are observed for inclusive high transverse momentum electrons and positrons in polarized p + p collisions at a center-of-mass energy of root s = 500 GeV with the PHENIX detector at RHIC. These e(+/-) come mainly from the decay of W-+/- and Z(0) bosons, and their asymmetries

Accumulating evidence suggest that platelets play an important role in regulating neutrophil recruitment in septic lung injury. Herein, we hypothesized that platelet-derived CCL5 might facilitate sepsis-induced neutrophil accumulation in the lung. Abdominal sepsis was induced by CLP in C57BL/6 mice. CLP increased plasma levels of CCL5. Platelet depletion and treatment with the Rac1 inhibitor NSC23

Recently, within a tunneling project, a method for reinjecting discharged groundwater at tunnel level has been investigated. The method was performed by pressurizing a long section of the lining With ungrouted pea gravel as backfill, in a rock mass with low hydraulic conductivity. Water was reinjected through watertight lining into a section where un-grouted pea gravel was used as backfill. The pr

For the last years, automation is widely used to relieve humans from repetitive tasks, primarily and firstly within manufacturing. However, for products with less ideal (or hard to model) properties, and when forces depends on human interaction, automated testing has not been explored until now. This work presents the analysis of the (human-dependent) motions/forces based on a fully implemented te

To assess an impact of vascular risk factors on ambulatory blood pressure measurement (ABPM) in the elderly, we followed up a population-based cohort of men from 68 until 82 years, when 104 survivors underwent ABPM. Results. At age 68, hypertension and high clinic blood pressure (CBP) did not predict ABPM level. Smoking and low ankle-brachial index (ABI) predicted higher ABPM variability and pulse