PURPOSE: To analyze the outcomes of cataract surgery complicated by posterior capsule rupture (PCR). SETTING: European clinics affiliated to the European Registry of Quality Outcomes for Cataract and Refractive Surgery (EUREQUO). DESIGN: Retrospective cross-sectional register-based study. METHODS: Data were retrieved from the EUREQUO between January 1, 2008, and December 31, 2018. The database con

Despite its role in ensuring the ubiquity of fossil fuels in modern society, the petrochemical sector has long flown under the public radar in energy and climate debates. However, faced with increasing pressures from its involvement in driving multiple and intersecting ecological crises, firms in the petrochemical industry are seeking to make sustainability a core part of their public image. Altho

Malaria är en sjukdom som orsakas av parasiter av plasmodium släktet och överförs mellan människor av myggor. Då myggan biter en malariasmittad människa och förtär dess blod så innehåller detta blod parasiter som i senare sprids ifrån myggans mage och vidare till dess salivkörtlar. När myggan vid ett senare tillfälle biter en frisk människa, överförs parasiten från salivkörtlarna till människans bMalaria is a massive global health crisis that is most prevalent in tropical regions of Africa, Asia, and Latin America. The World Health Organization (WHO) estimated in 2013 that 3.3 billion people were at risk of being infected by the disease, resulting in around 200 million cases with more than 500 000 of these cases leading to lethal outcome. Africa was by far the most affected by the disease

Introduction: There is a great need for fully automated plasma assays that can measure amyloid beta (Aβ) pathology and predict future Alzheimer's disease (AD) dementia. Methods: Two cohorts (n = 920) were examined: Panel A+ (n = 32 cognitively unimpaired [CU], n = 106 mild cognitive impairment [MCI], and n = 89 AD) and BioFINDER-1 (n = 461 CU, n = 232 MCI). Plasma Aβ42/Aβ40, phosphorylated tau (p-

Aims: Paediatric brain tumours are rare, and establishing a precise diagnosis can be challenging. Analysis of DNA methylation profiles has been shown to be a reliable method to classify central nervous system (CNS) tumours with high accuracy. We aimed to prospectively analyse CNS tumours diagnosed in Sweden, to assess the clinical impact of adding DNA methylation-based classification to standard p

Despite our growing understanding of the global carbon cycle, scientific consensus on the drivers and mechanisms that control dissolved organic carbon (DOC) turnover in aquatic systems is lacking, hampered by the mismatch between research that approaches DOC reactivity from either intrinsic (inherent chemical properties) or extrinsic (environmental context) perspectives. Here we propose a conceptu

Importance: Patients who survive severe intracerebral hemorrhage (ICH) and intraventricular hemorrhage (IVH) typically have poor functional outcome in the short term and understanding of future recovery is limited. Objective: To describe 1-year recovery trajectories among ICH and IVH survivors with initial severe disability and assess the association of hospital events with long-term recovery. Des

The objective of this study was to evaluate the performance of quantitative ultrasound of fetal lung texture analysis in predicting neonatal respiratory morbidity (NRM) in twin pregnancies. This was an ambispective study involving consecutive cases. Eligible cases included twin pregnancies between 27.0 and 38.6 weeks of gestation, for which an ultrasound image of the fetal thorax was obtained with

There is no inherent meaning in endurance experiences. The experience is accorded meaning in dialogue with the world around us. In this critical exploration of endurance running, endurance runners’ accounts of their consumption of endurance are analysed to reveal what they indicate about contemporary society. The findings question the idea - prevalent in consumer research - that endurance experien

The RNA genome of SARS-CoV-2 contains a 5′ cap that facilitates the translation of viral proteins, protection from exonucleases and evasion of the host immune response1–4. How this cap is made in SARS-CoV-2 is not completely understood. Here we reconstitute the N7- and 2′-O-methylated SARS-CoV-2 RNA cap (7MeGpppA2′-O-Me) using virally encoded non-structural proteins (nsps). We show that the kinase

ATP7B is a human copper-transporting P1B-type ATPase that is involved in copper homeostasis and resistance to platinum drugs in cancer cells. ATP7B consists of a copper-transporting core and a regulatory N-terminal tail that contains six metal-binding domains (MBD1-6) connected by linker regions. The MBDs can bind copper, which changes the dynamics of the regulatory domain and activates the protei

Background Indications with poor T-cell infiltration or deficiencies in T-cell priming and associated unresponsiveness to established immunotherapies represent an unmet medical need in oncology. CD40-targeting therapies designed to enhance antigen presentation, generate new tumor-specific T cells, and activate tumor-infiltrating myeloid cells to remodel the tumor microenvironment, represent a prom

Increasing tree growth and mortality rates in Europe are still poorly understood and have been attributed to a variety of drivers. This study explored the role of climate drivers, management and age structure in driving changes in tree mortality rates in six Central European countries from 1985 to 2010, using the process-based vegetation model LPJ-GUESS. Simulations show a strong positive trend in

To provide a complete portrayal of the multiple factors negatively impacting insects in agricultural landscapes it is necessary to assess the concurrent incidence, magnitude, and interactions among multiple stressors over substantial biogeographical scales. Trans-national ecological field investigations with wide-ranging stakeholders typically encounter numerous challenges during the design planni

The bromodomain and extra-terminal (BET) protein BRD4 regulates gene expression via recruitment of transcriptional regulatory complexes to acetylated chromatin. Like other BET proteins, BRD4 contains two bromodomains, BD1 and BD2, that can interact cooperatively with target proteins and designed ligands, with important implications for drug discovery. Here, we used nuclear magnetic resonance (NMR)

Previous research suggests associations between low systemic levels of vitamin D and poor breast cancer prognosis and between expression of the vitamin D receptor (VDR) in breast cancers and survival. This study aimed to study associations between pre-diagnostic systemic levels of vitamin D and expression of VDR in subsequent breast tumors, and interactions between vitamin D and VDR on breast canc

The new genus Kudratoviella for the former Caloplaca zeorina group having the highest level of bootstrap support in the phylogenetic tree of the Teloschistaceae, based on combined dataset of nrITS, 28S nrLSU DNA and 12S SSU mtDNA sequences, which does not belong to any other earlier proposed genera of the subfamily Xanthorioideae, is described. The genus Oceanoplaca Arup, Søchting et Bungartz founThe new genus Kudratoviella for the former Caloplaca zeorina group having the highest level of bootstrap support in the phylogenetic tree of the Teloschistaceae, based on combined dataset of nrITS, 28S nrLSU DNA and 12S SSU mtDNA sequences, which does not belong to any other earlier proposed genera of the subfamily Xanthorioideae, is described. The genus Oceanoplaca Arup, Søchting et Bungartz foun