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Squamous cell lung carcinoma (SqCC) is the second most common histological subtype of lung cancer. Besides tumor-initiating and promoting DNA, RNA, and epigenetic alterations, aberrant cell metabolism is a hallmark of carcinogenesis. This study aimed to identify SqCC-specific key regulators that could eventually be used as new anticancer targets. Transcriptional and metabolomic data were gathered

Population-specific thresholds have not been defined for the levels of adiposity and systemic biomarkers that predict chronic health risks in people with restricted growth conditions. Here, anthropometric measures of adiposity, basal metabolic requirements, and fasted blood samples were obtained from adults with restricted growth (age 41 ± 14 years, height 1.30 ± 0.10 m, body mass 60.5 ± 18.3 kg,

Background: Many traumatic brain injury (TBI) treatment protocols, including the Lund concept, advocate the highest point of the subarachnoid space (typically the vertex) as the zero-reference point for intracranial pressure (ICP) and the level of the right atrium as the zero-reference point for mean arterial blood pressure (MAP). In 2017, at the Department of Neurosurgery in Lund, Sweden, the zer

Parasitoid wasps are major causes of mortality of many species, making host immune defences a common target of adaptive evolution, though such targets outside model species are poorly understood. In this study, we used two tests of positive selection to compare across three closely related Galerucella leaf beetles that show substantial differences in their phenotypic response to the shared parasit

Objective: To estimate the effect on healthcare resource use after introducing the World Health Organization diagnostic criteria (WHO-2013) for gestational diabetes mellitus (GDM) compared to former criteria in Sweden (SWE-GDM). Design: A cost-analysis alongside the Changing Diagnostic Criteria for Gestational Diabetes (CDC4G) randomised controlled trial. Setting: Sweden, with risk-factor based sc

Background: In healthy hearts, left ventricular atrioventricular plane displacement (LVAVPD) measured by cardiac magnetic resonance (CMR) contributes to ∼60% of stroke volume. LVAVPD has been shown to correlate with maximal cardiac output and exercise capacity and is an independent predictor of outcomes in patients with heart failure. We aimed to assess if longitudinal pumping is altered, if LVAVP

The textile industry, dominated by fast fashion, has caused significant environmental and social harm. Its complex global long supply chains, spanning multiple countries and production steps, increases the challenges related to traceability, transparency, and accountability. To address these issues, the European Union has introduced the Ecodesign for Sustainable Products Regulation (ESPR), which w

Floods are among the most frequent and destructive natural disasters in Sub-Saharan Africa, exacerbated by climate change, rapid urbanisation, and inadequate infrastructure. In this context, drones, or Unmanned Aerial Systems (UAS), are increasingly recognised for their potential to enhance disaster management. Yet, adoption across the region remains fragmented, inconsistently integrated into work

Power sector decarbonisation is crucial for meeting global climate targets under the Paris Agreement as well as ensuring sustainable growth. Electricity and heat account for approximately 40% of energy‐related emissions and demand is only expected to increase, facilitating low‐carbon transitions in other sectors, from transport to industry. In response to the limitations of feed-in tariffs and ren

Syfte & mål: Syftet med detta examensarbete är att få en bättre förståelse för adaptiv återanvändning av kulturhistoriska byggnader och återbruk av byggmaterial inom byggbranschen, samt hur några vanliga utmaningar kopplat till detta kan hanteras. Målet med examensarbetet är att genom en fallstudie av Gjuteriet undersöka hur adaptiv återanvändning av kulturhistoriska byggnader och återbruk a

Theatre and archives have existed as parallel institutions for centuries, yet not much focus has historically been put on studying the function of archives within the theatrical institution. This thesis aims to examine the use and method of archives within Swedish institutional theatres by looking at the material that is created and used during a stage production at a Swedish institutional theatre

Background: Viral infections, including COVID-19, are associated with an increased risk for type 1 diabetes (T1D), but potential underlying mechanisms remain unexplored. We evaluated whether COVID-19 or influenza A infection is characterized by differential DNA methylation at immune and T1D susceptibility genes in young children at risk for T1D. Methods: Epigenome-wide association analysis using t

Aim: To summarise key epidemiological and therapeutic research on osteoarthritis (OA) published between April 2024 and March 2025. Methods: A narrative review was conducted using the MEDLINE database, focusing on English-language studies involving human participants published between April 1, 2024 and March 31, 2025. Eligible studies included observational longitudinal studies, systematic reviews,

Integrated pest management (IPM) is an important tool for sustainable crop production. IPM includes a diversity of methods, e.g., the use of biological control agents (BCAs) for disease control or growth promotion. While there is an increasing interest in the use of BCAs, less is known about their environmental costs and benefits on wild species, such as wild crop relatives. For example, a BCA may

Femoral neck fractures (FNFs) are associated with loss of function in all ages and excess mortality. The societal costs are high. Treatment needs to be tailored based on fracture type, functional demand, and physiological age of the patient. Internal fixation is often preferred for undisplaced FNFs and for displaced FNFs in young patients. Anatomical reduction is essential, but slight valgus is ac

When developing a research roadmap for human behaviour in fires, it is necessary to identify areas that require additional research. A general overview – from a multidisciplinary perspective – of gaps in human behaviour in fires research across multiple contexts is missing. The goal of this paper was to perform a scoping review to identify research gaps and themes in all aspects of human behaviour

Background: Perioperative stress or discomfort in shoulder arthroplasty (SA) patients can be reduced using more individually tailored patient education and expectation management. Most published studies assess pain and function for the first time at 6 weeks or 3 months. Consequently, there is no thorough understanding of day-to-day recovery trajectories within the first postoperative weeks, hinder