The recommended treatment for cutaneous squamous cell carcinoma is surgical excision. An initial punch biopsy is often performed as an aid to diagnosis. A retrospective registry-based study was performed to assess histopathological concordance of punch biopsy of cutaneous squamous cell carcinoma and subsequent excision. Analysis of 737 punch biopsies and subsequent matched excisions was performed.

BACKGROUND: Cardiovascular, respiratory, and musculoskeletal disease are among the leading causes of disability in middle-aged and older people. Health and lifestyle factors in youth have known associations with cardiovascular or respiratory disease in adulthood, but largely unknown associations with musculoskeletal disease.METHODS AND FINDINGS: We included approximately 40,000 18-year-old Swedish

Climate-vegetation feedbacks (CVFs) can amplify or mitigate climate variations. These feedbacks operate at multiple timescales. Fast processes such as leaf-scale carbon fluxes operate at sub-annual timescales, while slow processes, driven by changes in forest composition and structure, occur over decadal and longer timescales. Slow processes are rarely directly observed from instrumental data; yet

Land cover governs biogeophysical and biogeochemical feedbacks between the land surface and atmosphere. Holocene vegetation-atmosphere interactions are of particular interest, both to understand the climate effects of intensifying human land use and as a possible explanation for the Holocene Conundrum, a widely studied mismatch between simulated and reconstructed temperatures. Progress addressing

Portal hypertension, a life-threatening complication of cirrhosis,is largely triggered by increased intrahepatic vascular resistance.Fibrosis, regenerative nodule formation, intrahepatic angiogenisis and sinusoidalremodelling are classical mechanisms that account for increasedintrahepatic vascular resistance in cirrhosis. Our study leverages highresolution3D synchrotron radiation-based microtomogr

The installation of a second RF cavity in the UVX electron storage ring at the Brazilian Synchrotron Light Laboratory (LNLS) at the end of 2003 brought about longitudinal instabilities driven by one of the HOMs of the new cavity. Even though the operational difficulties related to these unstable modes were successfully overcome by means of a combination of cavity tuning (using temperature and plun

We describe recent efforts made at the Brazilian Synchrotron Light Source (LNLS) to improve beam orbit stability. The main driving force is the high positional stability required by some specific experiments and particularly by a high resolution undulator beamline which is being built at LNLS. Recent steps taken to improve orbit stability include the development of x-ray BPMs to measure the vertic

Land cover governs the biogeophysical and biogeochemical feedbacks between the land surface and atmosphere. Holocene vegetation-atmosphere interactions are of particular interest, both to understand the climate effects of intensifying human land use and as a possible explanation for the Holocene Conundrum, a widely studied mismatch between simulated and reconstructed temperatures. Progress has bee

This paper argues that conventional blame practices fall short of capturing the complexity of moral experiences, neglecting power dynamics and discriminatory social practices. It is evident that robots, embodying roles linked to specific social groups, pose a risk of reinforcing stereotypes of how these groups behave or should behave, so they set a normative and descriptive standard. In addition,

Introduction: Although climate change has been consistently identified as one of the greatest threats to humans, many clinicians do not feel prepared to address climate change with patients and medical school curricula still have very little coverage of its health consequences. At the same time, health care providers have been shown to be trusted voices and are therefore well suited to help build

A two-level three-factor factorial design experiment was conducted to study the influences of three critical specimen preparation parameters on the measurement results of bitumen by a dynamic shear rheometer (DSR). The investigated factors were (1) the pre-heating temperature (HT) for manufacturing the specimen, (2) the bonding temperature (BT) onto the rheometer, and (3) the trimming (Trim) opera

This paper introduces a novel method for solving the single-source localization problem, specifically addressing the case of trilateration. We formulate the problem as a weighted least-squares problem in the squared distances and demonstrate how suitable weights are chosen to accommodate different noise distributions. By transforming this formulation into an eigenvalue problem, we leverage existin

The only way to combat the depletion of resources and climate crisis is to reduceour dependence on fossil fuels. Renewable sources, such as wind and solar energy,are increasingly used to meet our ever-growing energy demands; however, they areintermittent. One promising solution to the power crisis in the world is fuel cells,which, unlike the combustion engine, can operate on renewable fuels such a