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Addition of a 50 mM mixture of l-arginine and l-glutamic acid (RE) is extensively used to improve protein solubility and stability, although the origin of the effect is not well understood. We present Small Angle X-ray Scattering (SAXS) and Nuclear Magnetic Resonance (NMR) results showing that RE induces protein compaction by collapsing flexible loops on the protein core. This is suggested to be a

A bioeconomy can be defined as an economy where the basic building blocks for materials, chemicals and energy are derived from renewable biological resources. This paper provides an overview of the bioeconomy in Europe, examining it from a policy framework and concept perspective. The role of bioenergy in the bioeconomy is discussed particularly through biofuels for transport and biorefineries. Th

Utvecklingen inom genetiken har möjliggjort att prediktiva genetiska tester kan utföras för ett antal mer eller mindre svåra sjukdomstillstånd. Det innebär att individer kan få reda på att de är bärare av ett sjukdomsanlag innan detta anlag ger upphov till konkreta och klara symptom. I spåren av dessa test uppstår ett gränsland mellan vad de genetiska testresultaten visar och uppkomsten av tydliga

Instead of discussing existing design methods that aim at bridging or annihilating gaps between users and designers, we want to highlight an approach for designers that helps us increase reflexivity of what is beyond our grasp when interacting with users. The first steps are to become aware of the gaps, identify them, and then manage them. This emphasises and makes visible to both parties the exis

Background: Women treated with gonadotropin-releasing hormone (GnRH) analogs may develop enteric neuropathy and dysmotility. Administration of a GnRH analog to rats leads to similar degenerative neuropathy and ganglioneuritis. The aim of this study on rat was to evaluate the early GnRH-induced enteric neuropathy in terms of distribution of neuronal subpopulations and gastrointestinal (GI) function

Typing performance of a full alphabet keyboard and a joystick type of mouse (with on-screen keyboard) provided by a wireless integrated tongue control system (TCS) has been investigated. The speed and accuracy have been measured in a form of a throughput defining the true correct words per minute [cwpm]. Training character sequences were typed in a dedicated interface that provided visual feedback

In this study, asymmetrical flow field-flow fractionation (AF4) coupled online with UV, multiangle light scattering (MALS), and fluorescence (FS) detectors (AF4-UV-MALS-FS) was employed for separation and characterization of egg yolk plasma. AF4 provided separation of three major components of the egg yolk plasma i.e. soluble proteins, low density lipoproteins (LDL) and their aggregates, based on

Parkinson´s disease (PD) is a neurodegenerative disorder characterized by the typical motor symptoms, akinesia/bradykinesia, rigidity and resting tremor. These symptoms are caused by a deficiency of dopamine (DA) in the brain, which depends on degeneration of DA neurons in the substantia nigra. The most effective treatment for PD is the DA precursor, L-DOPA. Unfortunately, within a few years, L-DO

Under chronically elevated N deposition, N retention mainly occur at high soil C-to-N ratio. This may be mediated through soil microbes, such as ectomycorrhizal (EM) fungi, saprotrophic fungi and bacteria, and the aim of this study was to evaluate the relationship between soil microbes and forest floor C-to-N ratios. Soil samples from 33 Norway spruce (Picea abies (L.) H. Karst) forests in Denmark

Popular Abstract in Swedish För att cellerna i kroppen ska fungera krävs det att proteinerna i cellerna beter sig som de ska, dvs att de signalerar på ett korrekt sätt. Det finns en mängd olika signalvägar i en cell och lika många olika mekanismer som styr signalvägarna. Mycket av det som sker i cellen regleras på ett eller annat sätt utifrån cellens genetiska kod som finns i DNA. DNA:t innehållerAberrant protein kinase C (PKC) activity and expression is implicated in different malignancies. To study the role of different PKC isoforms in breast cancer the expression of PCKα, δ and ε was evaluated in breast cancer tumors. In addition the effect of siRNA-mediated knockdown of the isoforms was studied in a global gene expression analysis. We found that high PKCα levels correlate with poor pro

Neural interfaces hold great promise to become invaluable clinical and diagnostic tools in the near future. However, the biocompatibility and the long-term stability of the implanted interfaces are far from optimized. There are several factors that need to be addressed and standardized when improving the long-term success of an implanted electrode. We have chosen to focus on three key factors when

In this paper, we propose a design framework for distributed embedded control systems that ensures reliable execution and high quality of control even if some computation nodes fail. When a node fails, the configuration of the underlying distributed system changes and the system must adapt to this new situation by activating tasks at operational nodes. The task mapping as well as schedules and con

Essän gör en läsning av den persiska poeten Forough Farrokhzad och undersöker hennes röst och roll i iransk litterär kvinnofrigörelse, utifrån en parallell med svensk och europeisk kvinnlig poesi på 60-70-talet och den position/handling som Cixous kallar écriture féminine.

The function of proteins depends crucially on conformational motions. The characteristic times of these motions extend from sub-picosecond to seconds. No single experimental tool can cover the entire time range and provide all necessary parameters for a complete understanding. Moreover, without a solid understanding of the data evaluation it is easy to misinterpret the complex phenomena. Because p

The natural language that accompanies the accounting language in financial reports is not only a more or less accurate representation of the company but also, the authors argue, a response to explicit as well as implicit external demands, expectations, and accusations. Drawing on the notion of accounts (i.e., statements or responses that neutralize critique of not meeting expectations), the author

Objective. To evaluate outcome after radical cystectomy for primary bladder cancer in a large population-based material. Material and methods. Between 1997 and 2002 all patients treated with radical cystectomy within 3 months after diagnosis of primary bladder cancer without distant metastasis were retrieved through the Swedish Bladder Cancer Registry. A follow-up questionnaire was distributed to