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The production of biopharmaceuticals so far has been based on batch processes that are robust and well-known, but very inefficient and inflexible, causing the products to be very expensive and process development to be slow and costly. The production of biopharmaceuticals is thus changing towards integrated continuous biomanufacturing (ICB) in order to reduce costs and increase flexibility in a co

Previously, microRNA‐100 (miR‐100) and its putative mRNA target, insulin‐like growth factor receptor‐1 (IGF1R) were identified as differentially and inversely expressed in bovine longissimus dorsi (LD) muscles with divergent intramuscular fat (IMF) content by our group. While IGF1R signaling is implicated in myogenesis and muscle lipid metabolism, the underlying regulatory mechanisms are poorly un

Rapporten fokuserar på hur Covid-19 har påverkat olika samhällsviktiga verksamheter i Skåne. Verksamheterna har påverkats mycket, men det har inte uppstått allvarliga funktionsstörningar. Undantagen är Hälso- och sjukvård samt omsorg, och Transportsektorn där även funktionspåverkan förekommit I rapporten analyseras även hur förberedelser har skett och vilka lärdomar som kan dras av Covid-19.

Based on concepts from quantum thermodynamics, the two-level system coupled to a single electromagneticmode is analyzed. Focusing on the case of detuning, where the mode frequency does not match the transitionfrequency, effective energies are derived for the levels and the photon energy. It is shown that these should be usedfor energy exchange with fermionic and bosonic reservoirs in the steady st

When training a deep learning model, the dataset used is of great importance to make sure that the model learns relevant features of the data and that it will be able to generalize to new data. However, it is typically difficult to produce a dataset without some bias toward any specific feature. Deep learning models used in histopathology have a tendency to overfit to the stain appearance of the t

OBJECTIVES: To examine how maternal and sociodemographic factors determine continued care-seeking behaviour from pregnancy to postnatal period in Kenya and Uganda and to determine associated neonatal survival outcomes.DESIGN: A population-based analysis of cross-sectional data using multinomial and binary logistic regressions.SETTING: Countrywide, Kenya and Uganda.PARTICIPANTS: Most recent live bi

Explosive remnants from military activities imply a complex and costly risk to be dealt with in society. The problem involves different risks that are currently managed in isolation and by different stakeholders. For prioritization and ranking between all contaminated areas, a common risk picture needs to be presented and communicated to decision-makers. This chapter analyses the pros and cons of

A three-dimensional numerical fluid-structure interaction (FSI) framework is successfully carried out on mechanical behaviour of new vortex generators (VGs) – rectangular trapezoidal winglet (RTW), angle rectangular winglet (ARW), curved angle rectangular winglet (CARW) – in smooth wavy fin-and-elliptical tube (SWFET) heat exchanger using the ANSYS MFX Multi-field® solver. The purpose of the prese

Convective heat transfer of aviation kerosene at supercritical pressures in a vertical upward tube of diameter 1.8 mm was numerically studied using RNG k-ε turbulence model with enhanced wall treatment. The thermo-physical and transport properties of the China RP-3 kerosene at various temperatures were obtained by a 10-species surrogate and the NIST Supertrapp software. The grid independence was f

Avtalsvitets relation till skada och skadestånd har sedan lång tid disku­terats i svensk juridisk litteratur. Någon samsyn i dessa frågor finns emeller­tid inte. Men med tre nya fall från Högsta domstolen kan man angripa problemen på nytt. Artikeln är ett bidrag dels till hur vi bör definiera avtalsvitet för att reglera dess relation till skada, dels hur två fall från Högsta domstolen bör förstås

Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use1. Despite advances in prevention and treatment, in particular through reducing low-density lipoprotein cholesterol levels2, heart disease remains the leading cause of death worldwide3. Genome-wideassociation studies (GWAS) of bloo

This paper describes and discusses the development of mobile exergames for children with cerebral palsy. The design process was built on co-design, and resulted in three activity games, two augmented reality (AR) games and one GPS based game. The resulting activity games were evaluated by 8 per-sons with cerebral palsy (CP). To complement this evaluation, the games have been evaluated against exis

I denna bok beskrivs och analyseras unga mäns berättelser om utsatthet för misshandel, rån och hot. Boken syftar till att visa på komplexiteten i ämnen som brott, offerskap och etnicitet. Ungdomar med svensk respektive invandrarbakgrund beskriver ofta varandra utifrån ett ”vi” och ett ”dom”. I mediaskildringar har denna dikotomi förstärkts vad gäller brottslighet och offererfarenhet. Men hur beskr

The aim of this theoretical paper is to critically reflect on the ethical and methodological issues that arose during a study that observed nurses’ care-giving in an intensive care unit setting. The authors critically discuss the methodological and ethical issues as well as the practical realities that were encountered when evaluating a complex intervention using unstructured qualitative observati

Although remarkable progress has been achieved in reducing hunger and poverty and improving people’s health in the past couple of decades, humanity still faces considerable socio-economic and sustainability challenges. Ensuring sustainable access to safe and sufficient water, improved sanitation facilities, clean energy sources and healthy food is a necessary requirement for ending hunger and pove